Paradoxical sleep deprivation: neurochemical, hormonal and behavioral alterations. Evidence from 30 years of research

Tufik, Sérgio; Andersen, Mônica Levy; Bittencourt, Lia; Mello, Marco Túlio de

doi:10.1590/s0001-37652009000300016

Cited by 137 publications

(88 citation statements)

References 133 publications

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“…A reduction of sleep time or quality might trigger several consequences to health, including impairments in immune response [35], sexuality [34,36], and metabolism [37]. Therefore, sleep disorders represent a high health risk associated to several comorbities [38]. The impact of sleep disorder upon functional capacity, health and well-being, added to the emotional overload that affects the family of a person with DMD, demonstrates the importance of sleep for the CM.…”

Section: The Sleep Of Caregiving Mothersmentioning

confidence: 99%

Caregivers’ sleep of Duchenne Muscular Dystrophy’s patients: a short review

Kt¹,

Editorial²,

Tufik³

et al. 2017

Transl Brain Rhythmicity

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The task of a caregiver might exert several effects upon his/her physical and psychological health. It should be highlight the role of the caregiving mother (CM) of patients with Duchenne Muscular Dystrophy (DMD). DMD is a genetic-character disease with a prevalence of 1 to every 3,500 boys live births and with high mortality rate. The disease´s progression significantly compromises the quality of life and mainly the patient´s independence, making it indispensible the presence of a caregiver. The overload of physical and emotionoal work, including nocturnal periods, may interfere with the CM´s sleep. CM with a son with DMD demonstrated lower sleep efficiency, higher sleep latency, and reported poor sleep quality. These modifications might negatively interfere with health and quality of life of these CMs. Therefore, the evaluation of sleep pattern and quality in this subjects is most important and essential, being for their own global health, as well as for the patient´s well-being. We point out the need for a major interest from the scientific community and health professionals in better understand the impact of chronic diseases on health and quality of life of caregivers and patients..

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Section: The Sleep Of Caregiving Mothersmentioning

confidence: 99%

Caregivers’ sleep of Duchenne Muscular Dystrophy’s patients: a short review

Kt¹,

Editorial²,

Tufik³

et al. 2017

Transl Brain Rhythmicity

View full text Add to dashboard Cite

show abstract

“…Therefore, PSD may lead to the failure of advanced neural functions, including decision-making, learning and memory (10,11).…”

Section: Crossmarkmentioning

confidence: 99%

Methodological Aspects of REM Sleep- Deprivation and Stereological Protocols in the Brain-Stem Respiratory Nuclei

Kamali

Noorafshan

Karimi

et al. 2016

Journal of Advanced Medical Sciences and Applied Technologies

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“…Although sleep functions are not completely known yet, it was assumed for several decades that brain activity was widely reduced or absent during sleep (Saper, 2005;Tufik et al 2009). However it is important to emphasize that even during sleep, the brain is 80% active, such 16 www.intechopen.com…”

Section: Sleep and Shift Workmentioning

confidence: 99%

Fatigue, Sleep Disorders, and Excessive Sleepiness: Important Factors for Nuclear Power Shift Workers

Paim¹,

Tufik²,

Mello³

2010

Nuclear Power

Self Cite

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In current urban societies, it is estimated that approximately 20% of the population does not work traditional working hours, and this percentage is tending to increase due to economic, demographic, and technological changes that have occurred in the last decades (Presser, 1999;Rajaratnam, 2001). From the middle of last century, researchers have reported (Bjerner, 1948;Andersen, 1970;Akerstedt, 1981) that working in shifts affects the health of workers; even then, it was shown that shift workers complained about fatigue and sleepiness. Around 81% of the workers complained about night shifts in contrast to only 4% for afternoon shifts (Bjerner, 1948). Production and distribution of electrical power from nuclear stations requires 24 h operation. Therefore, as in other sectors, the security of the whole operational system depends on the efficiency and the ability of the worker to execute tasks with remarkable accuracy and attention. However, because this type of energy is government-controlled, access to research in this area is mostly difficult; therefore, there is a scarcity of scientific publications related to the health of these shift workers. The objective of this chapter is to describe aspects related to sleepiness, particularly excessive day sleepiness, with respect to its origins and consequences as well as the forms of minimization and preventive strategies that can be adopted by companies that use shifts and night work. Such practices may reduce the number of accidents related to fatigue and sleepiness that occur inside and outside the work environment. Sleep and shift workAlthough sleep functions are not completely known yet, it was assumed for several decades that brain activity was widely reduced or absent during sleep (Saper, 2005;Tufik et al. 2009). However it is important to emphasize that even during sleep, the brain is 80% active, such 16 www.intechopen.com Nuclear Power 338that sleep is an active process of neuronal reorganization rather than just a process of diminishing wakefulness (Hobson, 2007). Currently, it is accepted that the wakefulness-sleep cycle in human beings is coordinated by two processes that interact among themselves: the homeostatic process (process S) and the circadian process (process C) (Borbely, 1982; Borbely, 1999). The homeostatic process reflects the duration of wakefulness and can be monitored by slow-wave activity (Dijk, 1990), while the circadian process occurs during a 24-hour time frame and sets the rhythms of several physiological activities. Both processes interact to consolidate sleep (Czeisler, 1980). The first systematic classification of sleep stages was described in the Standard Manual organized by Rechtschaffen and Kales (1968), where sleep was divided into NREM sleep (stages 1, 2, 3, and 4) and REM sleep. REM sleep alternates with NREM in intervals of 70 to 110 minutes that are repeated 4 to 6 times a night, depending on the total time slept (Silva, 1996). The duration of REM sleep episodes in humans progressively increases over a sleeping period, with lo...

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Paradoxical sleep deprivation: neurochemical, hormonal and behavioral alterations. Evidence from 30 years of research

Cited by 137 publications

References 133 publications

Caregivers’ sleep of Duchenne Muscular Dystrophy’s patients: a short review

Caregivers’ sleep of Duchenne Muscular Dystrophy’s patients: a short review

Methodological Aspects of REM Sleep- Deprivation and Stereological Protocols in the Brain-Stem Respiratory Nuclei

Fatigue, Sleep Disorders, and Excessive Sleepiness: Important Factors for Nuclear Power Shift Workers

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