Morphological, biochemical and histological effects of aqueous extracts of peanut (Arachis hypogaea) on swiss mice in different diets

Oliveira, Thárcia Kiara Beserra de; Gomes, Josivanda Palmeira; Júnior, Paulo Roberto da Silva; Lima, Antonia Barbosa de; Jordão, Ana Janaina Jeanine Martins de Lemos; Ramos, Katharina Rodrigues de Lima Porto; Silva, Joelmir Lucena Veiga da; Gonçalves, Chirlaine Cristine

doi:10.1590/acb360905

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…Peanut testa is rich in such phenolic compounds (Ma et al, 2014). In recent years, with the deepening of research on the important role of plant polyphenols in human health, more attentions have been paid to the nutritional value and function of peanut testa (Yu et al, 2006;Constanza et al, 2012;Liu et al, 2020;Oliveira et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…Flavonoids can provide protection against oxidative stress, which has been implicated in some human diseases (Karadag et al, 2009). For example, flavonoid play a positive role in the treatment of atherosclerosis, diabetes mellitus, chronic inflammation, and some types of cancers in humans (Pinent et al, 2004;Osakabe and Yamagishi, 2009;Liu et al, 2020;Oliveira et al, 2021). Due to these bioactivities for flavonoids in peanut testa, attempts have been made to use them in some form as functional food ingredients or purified drug (Francisco and Resurreccion, 2009;Hathorn and Sanders, 2012;Christman et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Targeted metabolome analysis reveals accumulation of metabolites in testa of four peanut germplasms

Zhang

Gangurde

et al. 2022

Front. Plant Sci.

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Cultivated peanut (Arachis hypogaea L.) is an important source of edible oil and protein. Peanut testa (seed coat) provides protection for seeds and serves as a carrier for diversity metabolites necessary for human health. There is significant diversity available for testa color in peanut germplasms. However, the kinds and type of metabolites in peanut testa has not been comprehensively investigated. In this study, we performed metabolite profiling using UPLC-MS/MS for four peanut germplasm lines with different testa colors, including pink, purple, red, and white. A total of 85 metabolites were identified in four peanuts. Comparative metabolomics analysis identified 78 differentially accumulated metabolites (DAMs). Some metabolites showed significant correlation with other metabolites. For instance, proanthocyanidins were positively correlated with cyanidin 3-O-rutinoside and malvin, and negatively correlated with pelargonidin-3-glucoside. We observed that the total proanthocyanidins are most abundant in pink peanut variety WH10. The red testa accumulated more isoflavones, flavonols and anthocyanidins compared with that in pink testa. These results provided valuable information about differential accumulation of metabolites in testa with different color, which are helpful for further investigation of the molecular mechanism underlying biosynthesis and accumulation of these metabolites in peanut.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Targeted metabolome analysis reveals accumulation of metabolites in testa of four peanut germplasms

Zhang

Gangurde

et al. 2022

Front. Plant Sci.

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In Vitro Digestion of Peanut Skin Releases Bioactive Compounds and Increases Cancer Cell Toxicity

Cordeiro-Massironi,

Soares-Freitas,

Sampaio

et al. 2023

Antioxidants

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Peanut skin is a rich source of bioactive compounds which may be able to reduce the risk factors associated with metabolic syndromes. This study aimed to characterize bio-compounds from peanut skin (Arachis hypogaea) and their bioactivity (antioxidant activity, inhibition of lipase, and carbohydrase enzymes) and to evaluate their anti-proliferative properties in colorectal cancer cells (HCT116) upon in vitro digestion. Peanut skin was digested in two sequential phases, and the final content, named phase-1 (P1) and phase-2 (P2) extracts, was evaluated. Several bioactive compounds were positively identified and quantified by liquid chromatography, including quinic acid, released especially after in vitro digestion. The total phenolic content and, regardless of the method, the antioxidant activity of P1 was higher than P2. P1 also showed a lower enzyme inhibitory concentration IC50 than P2, lipase, and α-glucosidase. For cell viability in HCT116 cells, lower concentrations of P1 were found for IC50 compared to P2. In conclusion, bioactive compounds were released mainly during the first phase of the in vitro digestion. The digested samples presented antioxidant activity, enzyme inhibitory activity, and cancer cell cytotoxicity, especially those from the P1 extract. The potential applications of such a by-product in human health are reported.

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Phylogenomic Analysis of Cytochrome P450 Gene Superfamily and Their Association with Flavonoids Biosynthesis in Peanut (Arachis hypogaea L.)

Zhang,

Qin,

Sun

et al. 2023

Genes

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Cytochrome P450s (CYPs) constitute extensive enzyme superfamilies in the plants, playing pivotal roles in a multitude of biosynthetic and detoxification pathways essential for growth and development, such as the flavonoid biosynthesis pathway. However, CYPs have not yet been systematically studied in the cultivated peanuts (Arachis hypogaea L.), a globally significant cash crop. This study addresses this knowledge deficit through a comprehensive genome-wide analysis, leading to the identification of 589 AhCYP genes in peanuts. Through phylogenetic analysis, all AhCYPs were systematically classified into 9 clans, 43 gene families. The variability in the number of gene family members suggests specialization in biological functions. Intriguingly, both tandem duplication and fragment duplication events have emerged as pivotal drivers in the evolutionary expansion of the AhCYP superfamily. Ka/Ks analysis underscored the substantial influence of strong purifying selection on the evolution of AhCYPs. Furthermore, we selected 21 genes encoding 8 enzymes associated with the flavonoid pathway. The results of quantitative real-time PCR (qRT-PCR) experiments unveiled stage-specific expression patterns during the development of peanut testa, with discernible variations between pink and red testa. Importantly, we identified a direct correlation between gene expression levels and the accumulation of metabolites. These findings offer valuable insights into elucidating the comprehensive functions of AhCYPs and the underlying mechanisms governing the divergent accumulation of flavonoids in testa of different colors.

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Morphological, biochemical and histological effects of aqueous extracts of peanut (Arachis hypogaea) on swiss mice in different diets

Cited by 3 publications

References 16 publications

Targeted metabolome analysis reveals accumulation of metabolites in testa of four peanut germplasms

Targeted metabolome analysis reveals accumulation of metabolites in testa of four peanut germplasms

In Vitro Digestion of Peanut Skin Releases Bioactive Compounds and Increases Cancer Cell Toxicity

Phylogenomic Analysis of Cytochrome P450 Gene Superfamily and Their Association with Flavonoids Biosynthesis in Peanut (Arachis hypogaea L.)

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