2021
DOI: 10.1590/acb360402
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Abstract: To assess the influence of prolonged cyclosporine use on the macro-and microscopic morphology of the spleen. Methods: 16 adult rabbits were divided into two groups (n = 8): group 1 -a placebo group, which was followed-up over a period of nine months; group 2 -which had taken an oral dose of cyclosporine (10 mg•kg -1 •day -1 ) over nine months. At the end of this period, the splenic histoarchitecture of all animals was evaluated and the splenic corpuscles were measured. Results: The spleens of the first group p… Show more

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