Image-guided study of swine anatomy as a tool for urologic surgery research and training

Smit, Jacob Hindrik Antunes; Leonardi, E; Chaves, Rosa Helena de Figueiredo; Furlaneto, Ismari Perini; Silva, Cezar Massoud Salame da; Abib, Simone de Campos Vieira; Góes, Adenauer Marinho de Oliveira

doi:10.1590/acb351208

Cited by 4 publications

(5 citation statements)

References 58 publications

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“…It should be noted that previous studies have indicated that there are no significant age and gender differences in ureteric diameter. 25 Studies have also shown that the anatomy and physiology of the porcine ureter are broadly comparable to the ones of the human ureter, 26 including its tissue structure 27 and urodynamic parameters. 28 For these reasons, the porcine urinary system is often employed in pre-clinical research on ureteric stents.…”

Section: Methodsmentioning

confidence: 94%

The accumulation of particles in ureteric stents is mediated by flow dynamics: Full-scale computational and experimental modeling of the occluded and unoccluded ureter

et al. 2022

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Ureteric stents are clinically deployed to restore urinary drainage in the presence of ureteric occlusions. They consist of a hollow tube with multiple side-holes that enhance urinary drainage. The stent surface is often subject to encrustation (induced by crystals-forming bacteria such as Proteus mirabilis) or particle accumulation, which may compromise stent's drainage performance. Limited research has, however, been conducted to evaluate the relationship between flow dynamics and accumulation of crystals in stents. Here, we employed a full-scale architecture of the urinary system to computationally investigate the flow performance of a ureteric stent and experimentally determine the level of particle accumulation over the stent surface. Particular attention was given to side-holes, as they play a pivotal role in enhancing urinary drainage. Results demonstrated that there exists an inverse correlation between wall shear stress (WSS) and crystal accumulation at side-holes. Specifically, side-holes with greater WSS levels were those characterized by inter-compartmental fluid exchange between the stent and ureter. These “active” side-holes were located either nearby ureteric obstructions or at regions characterized by a physiological constriction of the ureter. Results also revealed that the majority of side-holes (>60%) suffer from low WSS levels and are, thus, prone to crystals accumulation. Moreover, side-holes located toward the proximal region of the ureter presented lower WSS levels compared to more distal ones, thus suffering from greater particle accumulation. Overall, findings corroborate the role of WSS in modulating the localization and extent of particle accumulation in ureteric stents.

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Section: Methodsmentioning

confidence: 94%

The accumulation of particles in ureteric stents is mediated by flow dynamics: Full-scale computational and experimental modeling of the occluded and unoccluded ureter

et al. 2022

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“…With regard to bronchial measurements, we confirmed that the airway geometry of swine is similar to that in humans (Figure 5), consistent with previous studies. 1,3,4,8,11 The length and angle of the right main-stem bronchus were smaller than those of the left bronchus, suggesting that the right bronchi are shorter and steeper than the left main-stem bronchus. Similar findings have been reported in humans.…”

Section: Discussionmentioning

confidence: 99%

“…10 The anatomic and physiologic similarities of various organ systems, such as the respiratory system, between swine and humans, combined with the wide availability of swine, make swine useful options for research. 3,4,11 These benefits are especially true for research on airway stents and tracheal intubation.…”

Section: Introductionmentioning

confidence: 99%

CT Evaluation of the Tracheobronchial Tree in Swine

Gao,

Antunes,

Luu

et al. 2023

comp med

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Swine are commonly used for research on the respiratory system, but various anatomic features of the tracheobronchial tree of swine are poorly defined. The purpose of our study was to acquire normative measurements of the tracheobronchial tree of swine by using chest CT scans, thus laying a foundation for treating or studying airway disorders in this species. In our study, 33 male swine underwent thoracic CT scans; we measured anatomic features of the tracheobronchial tree, including the diameter, length, and angle of various airway structures. We further analyzed the relationships among selected principal parameters. Our data revealed several similarities and differences in anatomy between swine and humans. This information may be useful in future research.

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“…Топографія та васкуляризація нирок у тварин має важливе клінічне, діагностичне та хірургічне значення (Packialakshmi et al, 2020;Smit et al, 2021). Знання породних та вікових особливостей топографії та васкуляризації нирок у тварин дозволить ветеринарним спеціалістам своєчасно діагностувати захворювання нирок, проводити комплексне лікування з використанням паранефральної блокади, розробити нові методики оперативного втручання з мінімальною травматизацією органа.…”

Section: результати та їх обговоренняunclassified

Morphological characteristics of the kidneys of mature dogs (Canis Lupus Familiaris L., 1758)

Khomenko,

Sokulskyi,

Zaika

2024

SMLNUVMB

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Each biological species of animals is unique in its structure, which is due to the uniqueness of ecological habitats and the peculiarities of adaptation of homeostasis mechanisms to the influence of environmental factors. Subtle differences in the structural and functional components of organs found in different species of animals create a clear architecture for understanding the depth of biological processes. Research of species, breed and age macro- and microanatomical structures and their morphometric indicators of organs and systems should be considered as urgent tasks of modern morphology. The new data on the morphological indicators of organs discovered at the macro- and micro-levels make a certain contribution to the age-related, breed-related, comparative, experimental and clinical morphology of mammals. Urinary organs in the body of mammals play one of the leading roles in maintaining the physiological and biochemical status of the organism and homeostasis as a whole, which largely depends directly on the morphological and functional state of these organs. Increasingly, there is a need for comprehensive scientific studies of various departments of the urinary organs. The scientific article uses material that is a fragment of the planned research work of the department of normal and pathological morphology, hygiene and expertise “Development, morphology and histochemistry of animal organs in normal and pathological conditions”, state registration number 0120U100796. The article contains the results of the morphometric characteristics of the kidneys of sexually mature dogs – Canis lupus familiaris L., 1758. During the implementation of this work, complex research methods were applied: anatomical, histological, morphometric and statistical. For histological examination, a fragment of kidneys was selected, they were fixed in 10 % neutral formalin solution, Carnois and Buena fluid. In the future, dehydration was carried out in alcohols of increasing concentration and the procedure for sealing the organ was carried out according to generally accepted methods. Using a sled microtome, histological sections with a thickness of 7–10 μm were obtained. Processing of the results of histological sections was examined under a “Micros” light microscope with a digital camera at a magnification of × 100–400. The morphological study of the structural organs of the urinary system was studied on histological sections by the method of light microscopy in accordance with the requirements of the international principles of the “European Convention for the Protection of Vertebrate Animals Used in Experiments and Other Scientific Purposes” (Strasbourg, 1986), by the decision of the First National Congress on Bioethics (M. Kyiv, 2001), Law of Ukraine No. 692 “On the Protection of Animals from Cruel Treatment” (3447-IV) dated February 21, 2006. According to the histological structure, the kidneys of dogs are represented by renal corpuscles and renal tubules, which are made of epithelial cells. Organometric studies indicate that the absolute mass of kidneys in sexually mature dogs is 119.8 ± 6.48 g, relative – 0.74 ± 0.04 %. Morphometric studies of the kidney parenchyma in dogs have established that the average area of renal corpuscles is 4.89 ± 0.24 thousand μm², the area of the vascular glomerulus is 3.79 ± 0.18 thousand μm², the area of the Shumlyansky-Bowman capsule lumen is 1.12 ± 0.27 thousand μm². The average volume of renal bodies of the cortical substance is 1265.69 ± 239.34 thousand μm³. The number of renal corpuscles per conventional unit of area (5 mm²) is 20.8 ± 0.6 units. The aim of the work was to investigate the peculiarities of the morphogistological structure of the kidneys of sexually mature dogs. The research results will expand information about the morphological structure, and will serve for the development of issues of physiology, pathology and treatment of diseases of the urinary organs.

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Image-guided study of swine anatomy as a tool for urologic surgery research and training

Abstract: Substantive scientific and intellectual contributions to the study, conception and design, critical revision, final approval.

Cited by 4 publications

References 58 publications

The accumulation of particles in ureteric stents is mediated by flow dynamics: Full-scale computational and experimental modeling of the occluded and unoccluded ureter

The accumulation of particles in ureteric stents is mediated by flow dynamics: Full-scale computational and experimental modeling of the occluded and unoccluded ureter

CT Evaluation of the Tracheobronchial Tree in Swine

Morphological characteristics of the kidneys of mature dogs (Canis Lupus Familiaris L., 1758)

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