Serum ghrelin levels in papillary thyroid carcinoma

Uçan, Bekir; Şahi̇n, Mustafa; Kızılgül, Muhammed; Özbek, Mustafa; Özdemir, Şeyda; Çalışkan, Mustafa

doi:10.1590/2359-3997000000290

Cited by 4 publications

(4 citation statements)

References 38 publications

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“…However, the exact role of ghrelin in thyroid tumorigenesis is still debated. Ucan and colleagues (49) did not found any significant differences in serum ghrelin levels between patients with PTC and healthy controls. Our study demonstrated that AG concentrations were higher in the patients with malignant and benign thyroid nodules with respect to controls.…”

Section: Discussionmentioning

confidence: 90%

“…Ghrelin is implicated in several processes of cancer progression including cell proliferation, cell migration and invasion, angiogenesis and apoptosis, probably via an autocrine/paracrine mechanism (49). Some reports demonstrated that ghrelin may have an inhibitory effect in the proliferation of some cancer types, including thyroid, prostate, breast and small-cell lung carcinoma (50).…”

Section: Discussionmentioning

confidence: 99%

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Circulating adipokines and metabolic setting in differentiated thyroid cancer

Mele

Samà²,

Caputo

et al. 2019

Endocrine Connections

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The associative link relating insulin resistance (IR) and adipokines to the occurrence and phenotype of differentiated thyroid cancer (DTC) is unknown. The aim of this study was to evaluate the relationship between IR and adipokines in DTC patients, as compared with carriers of benign thyroid diseases (BTD) and healthy controls. This observational study enrolled 77 subjects phenotyped as DTC (N = 30), BTD (N = 27) and healthy subjects (N = 20). Each subject underwent preoperative analysis of anthropometric parameters, thyroid function and autoimmunity, insulin resistance (HOMA-IR) and levels of unacylated (UAG) and acylated ghrelin (AG), obestatin, leptin and adiponectin. Multivariate regression models were used to test the predictive role of metabolic correlates on thyroid phenotypes and DTC extension. The three groups showed similar age, gender distribution, smoking habit, BMI and thyroid parameters. Obestatin was significantly higher in DTC group compared to BTD (P < 0.05) and control subjects (P < 0.0001). DTC and BTD groups showed higher levels of UAG (P < 0.01) and AG (P < 0.05). Leptin levels were comparable between groups, whereas adiponectin levels were lower in DTC compared to BTD group (P < 0.0001) and controls (P < 0.01). In parallel, HOMA-IR was higher in DTC than BTD (P < 0.05) and control group (P < 0.01). Stepwise multivariable regression analysis showed that obestatin and UAG were independent predictors of DTC (P = 0.01 for both). In an analysis restricted to the DTC group, obestatin levels were associated with the absence of lymph node metastases (P < 0.05). Our results highlight a potential association between metabolic setting, circulating adipokines and thyroid cancer phenotype.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Circulating adipokines and metabolic setting in differentiated thyroid cancer

Mele

Samà²,

Caputo

et al. 2019

Endocrine Connections

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“…Figure 1 showed the details of systematic search process. Of these included 14 studies, three are published in Chinese [ 10 , 11 , 17 ] and the rest are all published in English [ 5 – 9 , 13 – 16 , 18 , 19 ]. Four studies were conducted in Turkey and three in China.…”

Section: Resultsmentioning

confidence: 99%

High prevalence of thyroid carcinoma in patients with insulin resistance: a meta-analysis of case-control studies

Zhao

Zhang

Yang

et al. 2021

Aging

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The association between insulin resistance and thyroid carcinoma is controversial. We conducted this meta-analysis of association between insulin resistance and thyroid carcinoma. There were 14 studies included in this meta-analysis. Random-effect model was used to merge the weighted mean difference value of fasting serum insulin level and the pooled effect shows that the level of fasting serum insulin is higher in patients with thyroid carcinoma than those of controls (1.88, 95% CI 0.87 to 2.90, P=0.0003). Random-effect model was used to estimate the pooled weighted mean difference and it shows that thyroid carcinoma patients have a higher level of homeostasis model assessment of insulin resistance (HOMA-IR) than patients without thyroid carcinoma (0.54, 95% CI 0.29 to 0.78, P<0.0001). Fixed-effect model with the odds ratio of insulin resistance shows that insulin resistance could increase the risk of thyroid carcinoma 216% compared with participants without insulin resistance (3.16, 95% CI 2.09 to 4.77, P<0.0001). In conclusion, insulin resistance might be a risk factor for thyroid carcinoma.

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“…Insulin resistance, a typical feature of patients with T2DM, is considered to be a risk factor for a variety of cancers, such as hepatocellular, breast cancer ( 34 , 35 ). Although several studies have found the relationship between insulin resistance and thyroid nodules or thyroid cancer ( 11 , 36 ), the role of insulin resistance in carcinogenesis of thyroid is still debatable, some studies have found a correlation ( 11 – 13 , 37 , 38 ), in contrast, others did not find positive results ( 15 , 39 – 41 ). In our study, ISI was associated with the aggressiveness of thyroid cancer, but HOMA-IR was not.…”

Section: Discussionmentioning

confidence: 99%

Abnormal Glucose Metabolism Parameters and the Aggressiveness of Differentiated Thyroid Carcinoma: A Hospital-Based Cross-Section Study in China

Zhao¹,

Tian²,

Jia³

et al. 2022

Front. Endocrinol.

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PurposeThe correlation of abnormal glucose metabolism and thyroid carcinoma, especially the aggressiveness of thyroid cancer, still remains controversial. We conducted this study to investigate the relationship between abnormal glucose metabolism parameters and differentiated thyroid carcinoma (DTC) in the Chinese population.Materials and MethodsThe study was designed as a hospital-based case–control study and was approved by the Ethics Committee of our hospital and registered in the Clinical Trial Protocol Registration and Results System (Registration code: NCT 03006289). From January 1, 2018 to June 30, 2021, a total of 377 DTC patients were enrolled in the study. Demographic and general characteristics, details of thyroid surgery and histopathological results, hematological test indicators were collected. Glucose metabolism parameters were calculated. Variables were analyzed by t-test, ANOVA, chi-squared analysis and Fisher’s exact test. Pearson bi-variate correlation and Spearman’s correlation analysis were used for bi-variate analysis.ResultsMore than 40% of patients with DTC were multifocality, more than half were extra-glandular invasion, and nearly 85% complied by lymph node metastasis. The prevalence of diabetes mellitus (DM) was about 10.08% in DTC patients. It was found that the proportion of postprandial 2 h blood glucose ≥11.1mmol/L and HbA1c ≥6.5% was significantly higher than the known proportion of DM (17.8%, 16.7% vs. 10.08%). Additionally, 87.3% of the DTC patients in this study had varying degrees of insulin resistance. Further analysis found that higher T staging was associated with higher levels of area under curve of C-peptide (P = 0.029), insulin sensitivity index (P = 0.012) and C-peptide sensitivity index (P = 0.016). A delayed peak of insulin secretion was found to be positive related with capsule invasion (r = 0.206, P = 0.004). In patients without a DM history, homeostasis model assessment of insulin resistance (P = 0.017), insulin sensitivity index (P = 0.019) and C-peptide sensitivity index (P = 0.020) were statistic associated with T staging. Also, the glucose metabolism parameter at 3-hour after a meal was related to a larger number of metastatic lymph nodes.ConclusionAbnormal glucose metabolism, namely, DM, hyperinsulinemia and insulin resistance, were significantly associated with the carcinogensis and aggressiveness of DTC.

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Serum ghrelin levels in papillary thyroid carcinoma

Cited by 4 publications

References 38 publications

Circulating adipokines and metabolic setting in differentiated thyroid cancer

Circulating adipokines and metabolic setting in differentiated thyroid cancer

High prevalence of thyroid carcinoma in patients with insulin resistance: a meta-analysis of case-control studies

Abnormal Glucose Metabolism Parameters and the Aggressiveness of Differentiated Thyroid Carcinoma: A Hospital-Based Cross-Section Study in China

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