2016
DOI: 10.1590/2359-3997000000184
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Abstract: Objective: Paraoxonase 1 (PON1) polymorphisms are associated with an increased susceptibility to cardiovascular disease. PON1 Q192R polymorphism (rs662) partially determine PON1 hydrolytic activity and protect against oxidation of LDL and HDL. This study aimed to delineate the association of PON1 status (functional 192 genotype and plasma activity levels) and atherogenicity in urbans residents aged 40 years or more. Materials and methods: Anthropometric data, lipid profiles, the atherogenic index of the plasma… Show more

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Cited by 8 publications
(7 citation statements)
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“…Results from different studies regarding the PON1 polymorphism and CVD are rather controversial. Some found positive association and others, among them one meta‐analysis study, did not find any association . There is also confirmatory evidence that low PON1 activity is positively associated with atherosclerosis, irrespective of PON1 genotype and/or activity phenotype .…”
Section: Pon1 and Diseases Connected With Atherosclerosis Developmentmentioning
confidence: 82%
“…Results from different studies regarding the PON1 polymorphism and CVD are rather controversial. Some found positive association and others, among them one meta‐analysis study, did not find any association . There is also confirmatory evidence that low PON1 activity is positively associated with atherosclerosis, irrespective of PON1 genotype and/or activity phenotype .…”
Section: Pon1 and Diseases Connected With Atherosclerosis Developmentmentioning
confidence: 82%
“…10 The PON1 p. Q192R missense variant (c.575A>G, rs662) is the most extensively characterized PON1 SNP and has been associated with CAD susceptibility in numerous studies. [11][12][13][14][15][16][17][18][19] Intriguingly, other studies could not replicate this association, whereby the role of PON1 Q192R in CAD remains controversial. [20][21][22] PON1 is considered a key factor for the bioactivation and clinical activity of clopidogrel, an ADP P2Y12 receptor antagonist recommended as a first-line treatment for ACS.…”
Section: Introductionmentioning
confidence: 95%
“…Allelic and genotypic frequencies were obtained from numerous studies for comparisons. [11][12][13][14][15][16][17][18][19][20][21][22][33][34][35][36][37][38][39][40][41] The P value for significance was set at < 0.05. Analyses were conducted using R v4.0.3 (R Core Team, 2014) or SPSS v26 208 software (IBM Analytics).…”
Section: Statistical Analysesmentioning
confidence: 99%
“…On the other hand, smokers with the rs662 GG genotype showed a higher atherogenic index and Framingham risk score than smoking and non-smoking AA + AG carriers. The rs662 GG genotype was discussed as associated with low arylesterase activity 23 . As one can see, the mentioned above data also do not provide thoroughly consistent results.…”
Section: Introductionmentioning
confidence: 99%