2016
DOI: 10.1590/2359-3997000000174
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Abstract: Although it is a rare condition, the accurate diagnosis and treatment of Cushing's disease is important due to its higher morbidity and mortality compared to the general population, which is attributed to cardiovascular diseases, diabetes mellitus and infections. Screening for hypercortisolism is recommended for patients who present multiple and progressive clinical signs and symptoms, especially those who are considered to be more specific to Cushing's syndrome, abnormal findings relative to age (e.g., spinal… Show more

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Cited by 16 publications
(28 citation statements)
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“…HDDST relies upon the fact that pituitary corticotroph tumour cells retain a degree of negative feedback response to glucocorticoids, unlike extra-pituitary tumours 62 63. In the standard/classic test, serum cortisol or UFC is measured after oral dexamethasone 2 mg administration every six hours for 2 days (total eight doses).…”
Section: Differential Diagnosis Of Confirmed Hypercortisolismmentioning
confidence: 99%
See 4 more Smart Citations
“…HDDST relies upon the fact that pituitary corticotroph tumour cells retain a degree of negative feedback response to glucocorticoids, unlike extra-pituitary tumours 62 63. In the standard/classic test, serum cortisol or UFC is measured after oral dexamethasone 2 mg administration every six hours for 2 days (total eight doses).…”
Section: Differential Diagnosis Of Confirmed Hypercortisolismmentioning
confidence: 99%
“…Alternatively, 8 mg dexamethasone can be administered orally at 23:00 with a subsequent serum cortisol measurement taken at 08:00 on the following day. A baseline cortisol measurement is performed in both these methods; a suppression of cortisol >50% compared with the baseline value would indicate a positive test result, which is suggestive of CS with a pituitary origin 1 62 63. However, about one-third of patients with ectopic ACTH-driven CS may also show cortisol suppression at these levels 61–63.…”
Section: Differential Diagnosis Of Confirmed Hypercortisolismmentioning
confidence: 99%
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