Association of polymorphisms within the Renin-Angiotensin System with metabolic syndrome in a cohort of Chilean subjects

Abstract

Objective: Metabolic syndrome (MetS) is associated with hypertension, obesity and dyslipidemia. Thus, genetic variants related with these conditions may modulate its development. We evaluated the effect of polymorphisms in the renin-angiotensin system (RAS) on metabolic syndrome risk in a cohort of Chilean subjects. Subjects and methods: A total of 152 subjects, 83 with MetS (51.2 ± 9.6 years) and 69 without MetS (49.5 ± 9.3 years) of both genders were included, according to the ATP III update criteria. The rs4340 Insertion/Deletion (I/D), rs699 (T>C) and rs5186 (A>C) of the ACE, AGT and AGTR1 genes, respectively, were genotyped. Results: After adjusting for age and gender, we observed the DD genotype of rs4340 associated with MetS (p = 0.02). Specifically, the DD genotype was associated with MetS risk in women (OR = 4.62, 95%CI, 1.41 -15.04; p < 0.01). In males, the AA genotype for rs5186 variant was associated with an increased risk for developing MetS when compared with women carrying the same genotype (OR = 3.2; 95%CI, 1.03 -9.89; p = 0.04). In subjects without MetS, DD genotype was associated with increased waist circumference (p = 0.023) while subjects with MetS carrying the rs5186 TT genotype showed higher levels of HDL-cholesterol (p = 0.031). Conclusion: The present study contributes data highlighting the role for RAS polymorphisms in predisposing to metabolic syndrome in Chilean subjects. Arch Endocrinol Metab. 2016;60(3):190-8

Genetic factors associated with obesity risks in a Kazakhstani population

“…Some of them include CRP (rs1205), MTHFR (rs1801133)obesity in children or adults, AGTR1 (rs5186), CBS (rs234706), MTHFR (rs1801131, rs1801133)-metabolic syndrome. [21][22][23][24][25][26][27] SNP in FUT2 gene (rs602662) revealed increased effect on BMI of German cohort of participants. 28 The full list of tested genes and SNPs is summarised in table 2.…”

Association of polymorphism genes LPL, ADRB2, AGT and AGTR1 with risk of hyperinsulinism and insulin resistance in the Kazakh population

“…Moreover, Goulart et al ( 33 ) reported that candidate genes associated with cardiovascular disease represent potential risk factors for the metabolic syndrome, and discovered that AGTR1 (rs5186) was associated with decreased risk of metabolic syndrome in postmenopausal women. Similarly, Herrera et al ( 34 ) revealed a higher risk of metabolic syndrome in male carriers of the AGTR1 (rs5186) A/A genotype. Furthermore, Akasaka et al ( 35 ) observed that genetic variants of RAS were involved in insulin sensitivity, and reported that the AGTR1 A1166C (rs5186) may affect insulin resistance.…”

Polycystic ovarian syndrome: rs1799752 polymorphism of ACE gene

“…[7][8][9] This polymorphism has already been associated with some clinical con-sequences of PCOS, such as hypertension 10,11 , diabetes 10 and metabolic syndrome. 12 Despite the importance of the ACE gene in ovarian physiology, studies published on polymorphisms in this gene and its susceptibility to PCOS are scarce and have shown controversial results. A meta-analysis involving six studies with 1,451 patients and 773 controls suggested that the polymorphism is associated with the risk of developing PCOS in Caucasian women.…”