Minimally invasive surgical interventions in the treatment of primary persistent hyperinsulinemic hypoglycemia of infancy

Soheilipour, Fahimeh; Jamshidi, Fatemeh; Ahmadi, Mohammad Reza; Pazouki, Abdolreza; Alibeigi, Peyman; Abdolhosseini, Mohammadreza

doi:10.1590/2359-3997000000094

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…Since the surgical stress associated with this operation is considerable, a therapeutic strategy should be planned, carefully weighing the risks of the surgery against the risks of continued medical treatment until spontaneous remission ( 92 ) by a multidisciplinary team including pediatric surgeons. There have been reports of laparoscopic pancreatectomy for CHI ( 93 , 94 , 95 , 96 ). Although the evidence is limited, laparoscopic pancreatectomy can be considered in experienced centers.…”

Section: Second Line Treatmentmentioning

confidence: 99%

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Clinical practice guidelines for congenital hyperinsulinism

Yorifuji

Horikawa

Hasegawa

et al. 2017

Clin Pediatr Endocrinol

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Abstract.Congenital hyperinsulinism is a rare condition, and following recent advances in diagnosis and treatment, it was considered necessary to formulate evidence-based clinical practice guidelines reflecting the most recent progress, to guide the practice of neonatologists, pediatric endocrinologists, general pediatricians, and pediatric surgeons. These guidelines cover a range of aspects, including general features of congenital hyperinsulinism, diagnostic criteria and tools for diagnosis, first- and second-line medical treatment, criteria for and details of surgical treatment, and future perspectives. These guidelines were generated as a collaborative effort between The Japanese Society for Pediatric Endocrinology and The Japanese Society of Pediatric Surgeons, and followed the official procedures of guideline generation to identify important clinical questions, perform a systematic literature review (April 2016), assess the evidence level of each paper, formulate the guidelines, and obtain public comments.

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Section: Second Line Treatmentmentioning

confidence: 99%

“…There have been reports of laparoscopic pancreatectomy for CHI ( 93 , 94 , 95 , 96 ). Although the evidence is limited, laparoscopic pancreatectomy can be considered in experienced centers.…”

Section: Second Line Treatmentmentioning

confidence: 99%

Clinical practice guidelines for congenital hyperinsulinism

Yorifuji

Horikawa

Hasegawa

et al. 2017

Clin Pediatr Endocrinol

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Open and laparoscopic resections of the pancreas in congenital hyperinsulinism

Sukhotskaya,

Bairov,

Kagantsov

et al. 2023

Endosk. khir.

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Successful laparoscopic resection of a rare focal form of congenital hyperinsulinism: Case report and literature review

Sukhotskaya

Kagantsov

Bairov

et al. 2023

Russian Journal of Pediatric Surgery, Anesthesia and Intensive

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Congenital hyperinsulinism is a severe disease that causes irreversible damage to the cerebral cortex. This article presents a clinical observation of successful surgical treatment for a child with an extremely rare form of hyperinsulinism accompanied by two foci in the opposite ends of the pancreas. The child was in extremely critical condition from birth due to recurrent hypoglycemia and was diagnosed with hyperinsulinism at the age of two weeks. Specific therapy with diazoxide and octreotide was initiated but proven to be ineffective (parenteral glucose administration was still needed, and octreotide only provided partial results). When the child was one month old, positron emission tomography-computed tomography with 18F-DOPA was performed and revealed the focal hyperfixation of the radiopharmaceutical in the tail and head of the pancreas. This finding indicated the presence of two pathological foci or a focus in the tail and the physiological accumulation of the radiopharmaceutical in the head. At the age of one month and 20 days, the child underwent laparoscopic revision of the pancreas to visualize a focus in the tail that was confirmed by express biopsy. The resection of the tail (15%) was performed with confirmation of clear resection margins. During further revision, a focus was detected in the head. Resection was again performed with histological confirmation of complete resection. On the 12th day after the operation, the child was discharged without therapy with clinical recovery. The child is currently being monitored (for over six months), growing and developing according to age. A fasting test was performed, and the recurrence of hyperinsulinism was ruled out. This article presents a detailed description of the clinical and radiological examination results, the patients history, the surgical techniques, and the intervention results. As part of the discussion, a literature review on the behavior of laparoscopic resections of the pancreas in children with congenital hyperinsulinism was carried out.

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Minimally invasive surgical interventions in the treatment of primary persistent hyperinsulinemic hypoglycemia of infancy

Cited by 3 publications

References 22 publications

Clinical practice guidelines for congenital hyperinsulinism

Clinical practice guidelines for congenital hyperinsulinism

Open and laparoscopic resections of the pancreas in congenital hyperinsulinism

Successful laparoscopic resection of a rare focal form of congenital hyperinsulinism: Case report and literature review

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