Clustering of risk factors for cardiometabolic diseases in low-income, female adolescents

Melo, Elza Maria Fernandes Seabra de; Azevedo, George Dantas de; Silva, João Batista da; Lemos, Telma Maria Araújo Moura; Maranhão, Técia Maria de Oliveira; Freitas, Anderson; Spyrides, Maria Helena Constantino; Costa, Eduardo Caldas

doi:10.1590/2359-3997000000083

Cited by 3 publications

(2 citation statements)

References 21 publications

(29 reference statements)

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“…Fewer studies (25)(26)38,39,51,52,62,66) used the NHLBI diagnosis criteria for elevated TC and LDL. Some studies (21)(22)(23)(24)(26)(27)(28)(29)(32)(33)(34)(35)(36)(37)(40)(41)(42)44,45,48,57,(59)(60)(61)63) used criteria from BSC but with the same cutoff for LDL values indicated by NHLBI (≥130 mg/dL).…”

Section: Resultsmentioning

confidence: 99%

Total cholesterol and low-density lipoprotein alterations in children and adolescents from Brazil: a prevalence meta-analysis

Silva¹,

Mendes²,

Barreto³

et al. 2022

Archives of Endocrinology and Metabolism

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Objective:The aim of the present study was to evaluate the prevalence of total cholesterol (TC) and low-density lipoprotein (LDL) alterations in children and adolescents in Brazil. Materials and methods: A systematic review and meta-analysis of prevalence. The search for articles was carried out in the databases: Medline (PubMed), Embase, Scientific Electronic Library Online (SciELO), Latin American and Caribbean Literature in Health Sciences (Lilacs). The meta-analysis was performed using the random effects model. The I² test was used to identify heterogeneity. Results: The present metanalysis revealed a significant prevalence of altered lipid profile in children and adolescents in Brazil. Regarding lipoprotein fractions, the prevalence of altered TC level was 27.47% (95% CI 24.36-30.82), and a smaller prevalence was observed for LDL cholesterol ). The models revealed high heterogeneity (I² = 99%; p < 0.01), however the precise source of it was not identified; although type of school, age group, year and the region of Brazil appeared to influence the estimations of altered lipid profiles. Conclusion: An important prevalence of lipid alterations was observed among Brazilian children and adolescents. Those results reinforce the importance of knowing the lipid profile of children and adolescents to perform early interventions for this public.

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Section: Resultsmentioning

confidence: 99%

Total cholesterol and low-density lipoprotein alterations in children and adolescents from Brazil: a prevalence meta-analysis

Silva¹,

Mendes²,

Barreto³

et al. 2022

Archives of Endocrinology and Metabolism

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show abstract

“…In this edition of the Archives of Endocrinology and Metabolism, three articles approach different aspects of the Metabolic Syndrome (3)(4)(5). The metabolic syndrome (and from now on I deliberately drop the capitals) has probably been one of the most popular philosophical constructs in the history of medicine.…”

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confidence: 99%

The quest for a metabolic theory of everything

Giuffrida

2016

Arch. Endocrinol. Metab.

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Cardiometabolic risk factors in South American children: A systematic review and meta-analysis

Singleton,

Brar,

Robertson

et al. 2023

PLoS ONE

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Background Cardiometabolic risk factors (impaired fasting glucose, abdominal obesity, high blood pressure, dyslipidemia) cluster in children, may predict adult disease burden, and are inadequately characterized in South American children. Objectives To quantify the burden of cardiometabolic risk factors in South American children (0–21 years) and identify knowledge gaps. Methods We systematically searched PubMed, Google Scholar, and the Latin American and Caribbean Health Sciences Literature via Virtual Health Library from 2000–2021 in any language. Two independent reviewers screened and extracted all data. Results 179 studies of 2,181 screened were included representing 10 countries (n = 2,975,261). 12.2% of South American children experienced obesity, 21.9% elevated waist circumference, 3.0% elevated fasting glucose, 18.1% high triglycerides, 29.6% low HDL cholesterol, and 8.6% high blood pressure. Cardiometabolic risk factor definitions varied widely. Chile exhibited the highest prevalence of obesity/overweight, low HDL, and impaired fasting glucose. Ecuador exhibited the highest prevalence of elevated blood pressure. Rural setting (vs. urban or mixed) and indigenous origin protected against most cardiometabolic risk factors. Conclusions South American children experience high rates of obesity, overweight, and dyslipidemia. International consensus on cardiometabolic risk factor definitions for children will lead to improved diagnosis of cardiometabolic risk factors in this population, and future research should ensure inclusion of unreported countries and increased representation of indigenous populations.

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Clustering of risk factors for cardiometabolic diseases in low-income, female adolescents

Cited by 3 publications

References 21 publications

Total cholesterol and low-density lipoprotein alterations in children and adolescents from Brazil: a prevalence meta-analysis

Total cholesterol and low-density lipoprotein alterations in children and adolescents from Brazil: a prevalence meta-analysis

The quest for a metabolic theory of everything

Cardiometabolic risk factors in South American children: A systematic review and meta-analysis

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