Puberty: When is it normal?

Brito, Vinícius Nahime; Latrônico, Ana Claudia

doi:10.1590/2359-3997000000018

Cited by 8 publications

(7 citation statements)

References 9 publications

(4 reference statements)

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“…Puberty is a transitional stage for an animal from the immature sexual state to the mature sexual state, and it marks the onset of reproductive capability [ 1 ]. Puberty is well known to be controlled by a range of complex factors and their interactions, including genetic, metabolic, neuroendocrine, nutritional, and environmental factors [ 2 ]. It is also well known that the hypothalamic-pituitary-gonadal (HPG) axis plays an important role in the regulation of genes such as Kiss-1/GPR54 , TAC3 , and TACR3 [ 3 , 4 ], MKRN3 [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

RNA-seq analysis of lncRNA-controlled developmental gene expression during puberty in goat & rat

Gao

Yang

et al. 2018

BMC Genet

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BackgroundPuberty is a pivotal stage in female animal development, and marks the onset of reproductive capability. However, little is known about the function of lncRNAs (long noncoding RNAs) in puberty. Therefore, RNA-seq analysis were performed between goats and rats to clarify the roles of lncRNAs and mRNAs in the onset of puberty.ResultsIn the present study, the length of lncRNAs, the length of the open reading frame and the exon count were compared between the two species. Furthermore, functional annotation analysis based on Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) analysis of lncRNAs target genes and differentially expressed mRNA demonstrated the significantly enriched terms, such as AMPK signaling pathway, oxytocin signaling pathway, insulin secretion as well as pheromone receptor activity, and some other signaling pathways which were involved in the regulation of female puberty. Moreover, our results of siRNA interference in vitro showed the candidate lncRNA XLOC_446331 may play a crucial role in regulating female puberty.ConclusionIn conclusion, the RNA-seq analysis between goat and rat provide novel candidate regulators for genetic and molecular studies on female puberty.Electronic supplementary materialThe online version of this article (10.1186/s12863-018-0608-9) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

RNA-seq analysis of lncRNA-controlled developmental gene expression during puberty in goat & rat

Gao

Yang

et al. 2018

BMC Genet

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“…Puberty is an essential and complex process, with a wide physiological variation of maturation, which consists of a period of transition between the immature to mature sexual state and culminates in the reproductive capacity and attainment of final stature after rapid somatic growth [1,2]. The onset and progression of this process may vary according to genetic, metabolic, socioeconomic, ethnic, and geographic characteristics, and it results in the reactivation of the hypothalamic-pituitary-gonadal (HPG) axis [3].…”

Section: Introductionmentioning

confidence: 99%

“…Peripheral precocious puberty is caused by extra pituitary secretion of gonadotropins or sex steroids, which may be of adrenal origin (congenital adrenal hyperplasia or adrenal tumors) or ovarian (autonomic follicular cysts or ovarian tumors) [13]. When pubertal events are incomplete, it is associated with normal variants of puberty (isolated early thelarche, early adrenarche, constitutional acceleration of growth and puberty) [1].…”

Section: Introductionmentioning

confidence: 99%

Differences in Puberty of Girls before and during the COVID-19 Pandemic

Neto

Azulay

Almeida

et al. 2022

IJERPH

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In the COVID-19 pandemic, there was an increase in consultations for precocious puberty. We aim to analyze differences in female puberty before and during the COVID-19 pandemic. A cross-sectional analytical study was designed at the Pediatric Endocrinology Clinic of the University Hospital of the Federal University of Maranhão in São Luis, Brazil. We included 55 girls with precocious puberty, 22 who started puberty during the pandemic and 33 who started puberty before the pandemic. Clinical, anthropometric, laboratory and imaging variables were compared between groups. Statistics were performed to determine if there was a statistical difference between the groups. Girls with puberty during the pandemic had higher Z-scores for weight (1.08 ± 1.29 versus 0.69 ± 0.83; p = 0.04), lower ovarian volume (1.88 ± 0.95 versus 3.15 ± 2.31; p = 0.01), and smaller differences between thelarche noticed by the parents and the diagnosis (6.63 ± 5.21 versus 12.15 ± 9.96; p = 0.02). The association between precocious puberty during the pandemic with higher Z-scores for weight, lower ovarian volume, and a reduction in the time between the perception of pubertal findings by parents and the diagnosis suggests the influence of the pandemic on the normal time of puberty.

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“…The mechanism underlying the onset of puberty is complex and reportedly involves several factors, including neuroendocrinological, genetic, and environmental factors [ 9 ]. The specific regulatory mechanism nevertheless remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Quantitative proteomics analysis to assess protein expression levels in the ovaries of pubescent goats

Qin

Gong

et al. 2022

BMC Genomics

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Background Changes in the abundance of ovarian proteins play a key role in the regulation of reproduction. However, to date, no studies have investigated such changes in pubescent goats. Herein we applied isobaric tags for relative and absolute quantitation (iTRAQ) and liquid chromatography–tandem mass spectrometry to analyze the expression levels of ovarian proteins in pre-pubertal (n = 3) and pubertal (n = 3) goats. Results Overall, 7,550 proteins were recognized; 301 (176 up- and 125 downregulated) were identified as differentially abundant proteins (DAPs). Five DAPs were randomly selected for expression level validation by Western blotting; the results of Western blotting and iTRAQ analysis were consistent. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis indicated that DAPs were enriched in olfactory transduction, glutathione metabolism, and calcium signaling pathways. Besides, gene ontology functional enrichment analysis revealed that several DAPs enriched in biological processes were associated with cellular process, biological regulation, metabolic process, and response to stimulus. Protein–protein interaction network showed that proteins interacting with CDK1, HSPA1A, and UCK2 were the most abundant. Conclusions We identified 301 DAPs, which were enriched in olfactory transduction, glutathione metabolism, and calcium signaling pathways, suggesting the involvement of these processes in the onset of puberty. Further studies are warranted to more comprehensively explore the function of the identified DAPs and aforementioned signaling pathways to gain novel, deeper insights into the mechanisms underlying the onset of puberty.

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Puberty: When is it normal?

Cited by 8 publications

References 9 publications

RNA-seq analysis of lncRNA-controlled developmental gene expression during puberty in goat & rat

RNA-seq analysis of lncRNA-controlled developmental gene expression during puberty in goat & rat

Differences in Puberty of Girls before and during the COVID-19 Pandemic

Quantitative proteomics analysis to assess protein expression levels in the ovaries of pubescent goats

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