Corticotropin-releasing factor receptor signaling and modulation: implications for stress response and resilience

Vasconcelos, Mailton; Stein, Dirson João; Gallas‐Lopes, Matheus; Landau, Luane Jandira Bueno; Almeida, Rosa M. M. de

doi:10.1590/2237-6089-2018-0027

Cited by 17 publications

(10 citation statements)

References 137 publications

(103 reference statements)

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“…Crf is known to be secreted by neurons in the paraventricular nucleus, which links stress‐related emotional responses and social interaction behaviours in mammals (Elliott et al, 2010; Ziv et al, 2012). Erk‐1 and ‐2 are known to act on target genes, such as crf or pomc (Vasconcelos et al, 2020). However, in the current study, the expression patterns of these two genes were not comparable in all brain regions, which still makes c‐fos a preferable indicator of stress in the carp brain.…”

Section: Discussionmentioning

confidence: 99%

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Differential effects of acute eustress and distress on gene regulation patterns in the carp ( Cyprinus carpio L.) brain

Pawlak

Burren

Seitz

et al. 2022

Aquaculture Research

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The activities of certain genes as a consequence of exposure to stressors related to typical handling procedures in aquaculture have not been studied in sufficient detail in fish. A stress trial with koi carp was, therefore, conducted, aiming at identifying relevant gene expression patterns in different brain regions during stress responses. The following stressors were selected: tank manipulation, distress caused by exposure to air and eustress due to feed rewards. Responses to these stressors were evaluated 10, 30 and 60 min after their application. The exact determination of gene expression profiles in the carp brain required the comparison of several suitable reference genes, which is also highly recommended for other studies focusing on the fish brain. Moreover, and as expected, the mRNA expression of a number of early immediate genes indicated activity in different brain regions as a response to changes in rearing and experimental conditions. In addition, the mRNA expression of metabolic genes was investigated, since increased brain activity may also increase the metabolic demands of certain brain areas. Furthermore, genes related to the stress axis were included in the study. The mRNA expression patterns of genes belonging to the stress axis revealed that negative stress caused by exposure to air had broad‐ranging effects on the gene regulation patterns in the fish brain, even if the fish were only treated for 1 min. This parallels the effects that have been observed on blood cortisol and glucose. In contrast, a limited number of genes allows discrimination of eustress and distress, which indicates that further research is needed in the future. Finally, the use of different control groups is highly recommended for fish experiments to correct for typical experimental procedures such as lid openings or social isolation.

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Section: Discussionmentioning

confidence: 99%

“…Crf is known to be secreted by neurons in the paraventricular nucleus, which links stress-related emotional responses and social interaction behaviours in mammals (Elliott et al, 2010;Ziv et al, 2012). Erk-1 and -2 are known to act on target genes, such as crf or pomc (Vasconcelos et al, 2020).…”

Section: Immediate Early Genesmentioning

confidence: 99%

Differential effects of acute eustress and distress on gene regulation patterns in the carp ( Cyprinus carpio L.) brain

Pawlak

Burren

Seitz

et al. 2022

Aquaculture Research

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“…Previous genetic association studies and polygenic risk scores ( 49 – 51 ) showed that re-experiencing symptoms have been associated with the CRHR1 gene (corticotropin-releasing hormone receptor 1). CRHR1 is involved in the stress-response system by allostatic load and immune response to stress ( 52 – 54 ). These studies provide additional evidence to our findings suggesting that re-experiencing symptoms may be related to impairment in regulating the immune system, which may cause TL changes.…”

Section: Discussionmentioning

confidence: 99%

Shorter Telomeres Related to Posttraumatic Stress Disorder Re-experiencing Symptoms in Sexually Assaulted Civilian Women

et al. 2022

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Telomeres are short tandem repeats of “TTAGGG” that protect the chromosome ends from deterioration or fusion of chromosomes. Their repeat length shortens with cell division acting as a biomarker of cellular aging. Traumatic stress events during adulthood or childhood have been associated with posttraumatic stress disorder (PTSD) and short leukocyte telomere length (LTL). This study investigated whether LTL was associated with PTSD in a Brazilian sample of sexually assaulted civilian women at two time points: baseline and 1-year follow-up. At baseline, we assessed 64 women with PTSD following sexual assault (cases) and 60 women with no previous history of sexual trauma or mental disorders (healthy controls – HC). At follow-up visit, 13 persistent PTSD cases, 11 HCs, and 11 PTSD remitters patients were evaluated. PTSD diagnosis and severity were assessed using Mini International Neuropsychiatric Interview (Diagnostic and Statistical Manual of Mental Disorders III/IV criteria) and Clinician-Administered PTSD Scale for DSM-5 (CAPS-5), respectively. LTL was measured using multiplex real-time polymerase chain reaction (PCR). In the baseline analysis, we observed that LTL was associated with re-experiencing symptoms (B = −0.16; confidence interval (CI) 95% = −0.027—−0.005; Bonferroni-adjusted p-value = 0.02), but no association was observed between other PTSD symptoms and LTL. In the longitudinal analysis, telomere shortening was no longer observed in patients with PTSD and PTSD remitters. In conclusion, our findings indicate that shorter baseline LTL is associated with early stage of PTSD re-experiencing symptoms in recently sexually assaulted women.

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“…It has been shown that with different levels of response to stress, women are more sensitive to the release of corticotropin-releasing factor (CRF) (Bangasser and Wiersielis, 2018 ). Inappropriate or persistent CRF release is strongly linked to depression and anxiety (Vasconcelos et al, 2020 ). In addition, hormonal changes in women during the menstrual cycle or menopause can also lead to more pronounced mood changes (Christiansen and Berke, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Risk Factors Associated With Mental Health Symptoms Among the Outpatient Psychiatric Patients and Their Family Members in China During the Coronavirus Disease 2019 Pandemic

et al. 2021

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Objective: To investigate the prevalence of and risk factors associated with mental health symptoms in psychiatric outpatients and their family members in China during the COVID-19 pandemic.Methods: This cross-sectional, survey-based, region-stratified study collected demographic data and mental health measurements for depression, anxiety and acute stress from 269 psychiatric patients and 231 family members in the Second Xiangya Hospital in China from April 27, 2020 to May 8, 2020. Binary logistic regression analysis was performed to identify risk factors associated with mental health outcomes.Result: The results of this survey revealed that symptoms of depression, anxiety, and acute stress were highly prevalent symptoms in the psychiatric patient group. Respondents who were female, unmarried or highly educated were significantly more likely to have the above symptoms. In the family member group, more than half of them felt that the burden of nursing had increased during the epidemic. Subjects with a high degree of burden of care were significantly more likely to exhibit the above mental health symptoms, while females were significantly more likely to have acute stress.Conclusions: The results of this survey revealed a high prevalence of mental health disorder symptoms among psychiatric patients and an increased burden of nursing among their family members after the COVID-19 outbreak in China. Understanding the risk factors in those particular groups of people help improve the public health service system for mental health problems during public health events. For further study, exploration of the needs of mental health services and dynamic change tracking will be needed.

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Corticotropin-releasing factor receptor signaling and modulation: implications for stress response and resilience

Cited by 17 publications

References 137 publications

Differential effects of acute eustress and distress on gene regulation patterns in the carp ( Cyprinus carpio L.) brain

Differential effects of acute eustress and distress on gene regulation patterns in the carp ( Cyprinus carpio L.) brain

Shorter Telomeres Related to Posttraumatic Stress Disorder Re-experiencing Symptoms in Sexually Assaulted Civilian Women

Prevalence of Risk Factors Associated With Mental Health Symptoms Among the Outpatient Psychiatric Patients and Their Family Members in China During the Coronavirus Disease 2019 Pandemic

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