Can physical exercise modulate cortisol level in subjects with depression? A systematic review and meta-analysis

Beserra, A.H.N.; Kameda, Priscila; Deslandes, Andréa Camaz; Schuch, Felipe Barreto; Laks, Jérson; Moraes, Helena

doi:10.1590/2237-6089-2017-0155

Cited by 58 publications

(34 citation statements)

References 40 publications

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“…The greater improvement percentage in group (B) than in group (A) reflected the beneficial effect of walking program on a treadmill on lowering serum cortisol levels in PMS females. This result can be supported with Beserra et al (24) who revealed a positive effect of physical exercising on reducing cortisol concentrations in individuals with major depressive disorder. Moreover, sensitivity analysis and subgroup analyses showed an influence of exercise type (aerobic exercise) on lowering cortisol concentrations.…”

Section: Discussionsupporting

confidence: 71%

Effect of Walking on Physiological Stress in Premenstrual Syndrome:A Randomized Controlled Trial

Ibrahim

Yousef

Elainin³

et al. 2020

Egyptian Journal of Physical Therapy

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Purpose: To investigate the effect of walking on physiological stress in premenstrual syndrome (PMS). Methods: Thirty females with PMS were randomly distributed into two equal groups. Group (A) (n=15) received breathing exercises, while group (B) (n=15) received the same breathing exercises in addition to walking on a treadmill. The primary outcomes were serum cortisol levels, resting heart rate (HR) and resting respiratory rate (RR) to measure the level of physiological stress, while the secondary outcomes were daily record of severity of problems (DRSP) and abdominal pain assessed by visual analogue scale (VAS). The outcome measures were evaluated pre-treatment and after 8 weeks of treatment. Results: Comparing both groups post-treatment revealed non-significant differences in serum cortisol levels, resting HR and DRSP (P>0.05), while there were significant reductions in both resting RR and abdominal pain VAS (P<0.05) in favor of group (B). The percentages of improvement post-treatment in serum cortisol levels, resting HR, resting RR, DRSP and abdominal pain VAS were 16.05%, 2.92%, 5.19%, 29.73% and 25.84%, respectively in group (A), while they were 25.09%, 7.05%, 15.69%, 31.43% and 55.30%, respectively in group (B). Conclusion: Walking is effective in treating premenstrual syndrome through reducing resting RR and abdominal pain intensity, as well as producing greater improvement in serum cortisol levels, resting HR and severity of PMS symptoms.

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Section: Discussionsupporting

confidence: 71%

Effect of Walking on Physiological Stress in Premenstrual Syndrome:A Randomized Controlled Trial

Ibrahim

Yousef

Elainin³

et al. 2020

Egyptian Journal of Physical Therapy

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“…62,63 In a systematic review and meta-analysis study, the physical exercise showed to promote the levels of cortisol among subjects with mild depression disorders (MDD), whoever these findings significantly controlled by the type of exercise, frequency, and the type of cortisol measurement. 69 Several studies performed on middle-aged/older adult individuals suggest beneficial positive effects on mood, well-being, and cognition. [70][71][72] In a recent pilot study, the feasibility of aerobic exercise as an antidepressant treatment strategy was evaluated in young adults with MDD.…”

Section: Introductionmentioning

confidence: 99%

<p>Hormonal Function Responses to Moderate Aerobic Exercise in Older Adults with Depression</p>

Alghadir¹,

Gabr²

2020

CIA

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Background: Poor daily life physical activities among older people were related to depressive mood especially memory loss. In addition to that, the change in physical ability is significantly associated with the score of depression among older age. Objective: The present study aimed to evaluate the effects of a supervised aerobic training program with moderate intensity for 12 weeks on mood profiles and hormonal levels of the hypothalamus-pituitary-adrenal axis (HPA axis) of older adults. Methods: A total of 80 individuals of both gender (90 males, 110 females) of ages ranged between 65 and 95 years were recruited for this study. Based upon the profile of mood states (POMS) analysis, the participants were classified into two groups: control group (n=30) and depressive group (n=50). Leisure-time physical activity (LTPA), adrenal hormones such as ACTH, corticosterone (CORT), cortisol, DHEA/S, and cortisol:DHEA/S ratio were measured at baseline and post-intervention of moderate aerobic exercise for 12 weeks. Results: Older adults with higher depressive scores showed a remarkable change in the level of adrenal hormones compared to control. There was a significant increase in the level of ACTH, CORT, cortisol, and cortisol:DHEA/S ratio, and decrease in DHEA/S. Compared to females, males showed an improvement in depressive mood score along with an increase in LPTA, DHEA/S and decrease in ACTH, CORT, cortisol, cortisol:DHEA/S ratio following 12 weeks of supervised aerobic training, respectively. Conclusion: The findings of this study showed that 12 weeks of supervised exercise interventions are promising non-drug therapeutic strategies in improving depression among older adults. The potential performance in a psychological state occurs physiologically via optimizing the levels of the hormones of the HPA axis.

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“…Considering the moderating effects of social support for the relationship between SLE and HCC, mental health practitioners should provide more social and psychological support to schizophrenia patients throughout the course of this disease, especially in the stable phase (20,43,56). Furthermore, aerobic exercises have been proved to decrease the cortisol levels (57). Taichi is a form of physical exercise and moving meditation originated in China.…”

Section: Discussionmentioning

confidence: 99%

Hair Cortisol Is Associated With Social Support and Symptoms in Schizophrenia

et al. 2020

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Introduction: Psychosocial stressors may worsen psychotic symptoms in schizophrenia, while social support could protect against the effects of stress in schizophrenia. Hypothalamus-pituitary-adrenal axis dysfunction has been associated with schizophrenia. Hair cortisol concentrations (HCC) allow assessment of cumulative cortisol secretion over the preceding 3 months. The relationship between HCC, psychosocial stressors, social support, and the clinical characteristics of schizophrenia needs to be explored. Methods: One hundred nine schizophrenia patients and 86 healthy controls between the ages of 18 and 60 were enrolled in the study. Three-centimeter samples of hair were collected from the scalp and HCC were measured using ELISA kits. Linear regression and factor analysis were employed to examine the relationship between HCC, childhood trauma, the number of stressful life events (SLE), the amount of social support in the 3 months prior to the hair cortisol assessment and clinical characteristics of schizophrenia. Results: Schizophrenia patients experience more SLE in their lifetime, receive less social support, and have lower HCC in the recent 3 months compared to healthy controls. In the schizophrenia patients, HCC are positively associated with the amount of social support and negatively associated with the severity of delusions. The interaction between social support and SLE predicts decreased HCC. Factor analysis shows that a subgroup of schizophrenia patients who experience childhood trauma and SLE are characterized by decreased HCC. Conclusions: Findings indicate social support could be a moderator for the relationship between SLE and HCC which may attenuate the effects of SLE in schizophrenia.

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Can physical exercise modulate cortisol level in subjects with depression? A systematic review and meta-analysis

Cited by 58 publications

References 40 publications

Effect of Walking on Physiological Stress in Premenstrual Syndrome:A Randomized Controlled Trial

Effect of Walking on Physiological Stress in Premenstrual Syndrome:A Randomized Controlled Trial

<p>Hormonal Function Responses to Moderate Aerobic Exercise in Older Adults with Depression</p>

Hair Cortisol Is Associated With Social Support and Symptoms in Schizophrenia

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