2018
DOI: 10.1590/2237-6089-2017-0130
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Abstract: MDD seems to be associated with global HcV atrophy. Larger longitudinal follow-up studies designed to analyze the influence of sociodemographic variables on this relationship are required to yield better evidence about this topic.

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Cited by 55 publications
(32 citation statements)
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“…We observed significant differences in adult MDD patients in WM tracts that lead to the hippocampus, including the fornix/stria terminalis and the hippocampal portion of the cingulum bundle. Smaller hippocampal volumes (on average) is one of the most consistently reported neuroimaging findings in the depression literature (for meta-analyses please see [3,51]). Similar mechanisms may underlie both findings.…”
Section: Discussionmentioning
confidence: 99%
“…We observed significant differences in adult MDD patients in WM tracts that lead to the hippocampus, including the fornix/stria terminalis and the hippocampal portion of the cingulum bundle. Smaller hippocampal volumes (on average) is one of the most consistently reported neuroimaging findings in the depression literature (for meta-analyses please see [3,51]). Similar mechanisms may underlie both findings.…”
Section: Discussionmentioning
confidence: 99%
“…We focused our gene expression and electrophysiological studies on the hippocampus, which has been strongly implicated in mood-related disorders [127][128][129] . Early stress influences both hippocampal neuronal morphology and plasticity, features that contribute to the behavioral sequelae of early trauma [130][131][132][133] .…”
Section: Discussionmentioning
confidence: 99%
“…Depression is recognized not to result from any specific pathology affecting only single-cell types or areas but is characterized by altered functioning of a more complex cortico-limbic circuitry. The medial prefrontal cortex, particularly the subgenual cingulate cortex (SCC), along with connecting subcortical structures, such as the hippocampus (Videbech and Ravnkilde, 2004;Kempton et al, 2011;Santos et al, 2018), the amygdala, and the nucleus accumbens, are affected (Ressler and Mayberg, 2007;Heshmati and Russo, 2015;Akil et al, 2018). Hyperactive hypothalamus-pituitary adrenal axis and the overproduction of stress hormones, decreased neurotrophic support, and reduced neuronal plasticity are thought to underlie some of the atrophic changes associated with depression (Lee et al, 2002;Duman and Monteggia, 2006;Castrén et al, 2007;Liu et al, 2017).…”
Section: The Neurobiological Premise Of Major Depressionmentioning
confidence: 99%