2018
DOI: 10.1590/2237-6089-2017-0025
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Abstract: Introduction: Bipolar disorder (BD) is a debilitating mood condition that affects approximately 1.3% of people worldwide, although some studies report up to 3.9% lifetime prevalence and 4-6% in adults when broad diagnostic criteria are applied. Objective: To compare differences in total white matter (WM), corpus callosum (CC) and total gray matter (GM) volumes in patients with type I BD at early and late stages compared with controls. Methods: Fifty-five subjects were enrolled in this study protocol. The dou… Show more

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Cited by 8 publications
(7 citation statements)
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“…WM abnormalities are consistently reported in first episode BD, 47 and we found reduced WMV in the GI subgroup of first episode BD patients. However, no significant regional WMV differences were detected.…”
Section: Discussionsupporting
confidence: 79%
See 1 more Smart Citation
“…WM abnormalities are consistently reported in first episode BD, 47 and we found reduced WMV in the GI subgroup of first episode BD patients. However, no significant regional WMV differences were detected.…”
Section: Discussionsupporting
confidence: 79%
“…45 That unaffected relatives of GI patients themselves exhibit cognitive deficits also support the existence of a neurodevelopmentally distinct GI subgroup. 46 WM abnormalities are consistently reported in first episode BD, 47 and we found reduced WMV in the GI subgroup of first episode BD patients. However, no significant regional WMV differences were detected.…”
Section: Discussionsupporting
confidence: 78%
“…Lavagnino et al (2015) identified significant decreases in the volume of the posterior corpus callosum in late stage patients compared to individuals in the early stage and the control group. In Duarte et al (2018), the authors found a decrease in corpus callosum volume in early and late stage patients relative to the control group. Duarte et al (2018) also found a significant decrease in total white matter (WM) volume and total grey matter (GM) volume in late stage patients compared to the control group.…”
Section: Brain Changesmentioning
confidence: 94%
“…In Duarte et al (2018), the authors found a decrease in corpus callosum volume in early and late stage patients relative to the control group. Duarte et al (2018) also found a significant decrease in total white matter (WM) volume and total grey matter (GM) volume in late stage patients compared to the control group. While the authors identified a decrease in total WM volume in patients at early stages compared to the control group, no significant change in total GM volume between early stage patients and the control group were detected.…”
Section: Brain Changesmentioning
confidence: 94%
“…77,78 In the state of Rio Grande do Sul, knowledgeable clinical and basic science research groups based at the Federal University of Rio Grande do Sul (UFRGS) and the Pontifical Catholic University (PUC) have adopted the first model outlined in the previous section of this article, testing original hypotheses in a number of psychiatric neuroimaging studies carried out in collaboration with teams of imaging experts either from the local Clinics Hospital of Porto Alegre (HCPA), the PUC-based Brain Institute (InsCer), or Sã o Paulo-based centers. These groups have contributed to the development of the field of psychiatric neuroimaging in Brazil by leading studies on attention-deficit/hyperactivity disorder (ADHD), [79][80][81] child and adolescent development, 82,83 psychosis, 84 mood and anxiety disorders, [85][86][87] and autism (Table 1). 88 The same collaborative model has been applied by research groups based at other universities in Brazil.…”
Section: Psychiatric Neuroimaging In Brazilmentioning
confidence: 99%