IL-6 and IL-10 levels in the umbilical cord blood of newborns with a history of crack/cocaine exposure in utero: a comparative study

Mardini, Victor; Rohde, Luís Augusto; Ceresér, Keila Maria Mendes; Gubert, Carolina; Silva, Emily Galvão da; Xavier, Fernando Antonio Costa; Parcianello, Rodrigo Ritter; Röhsig, Liane Marise; Pechansky, Flávio; Pianca, Thiago Gatti; Szobot, Cláudia Maciel

doi:10.1590/2237-6089-2015-0081

Cited by 8 publications

(9 citation statements)

References 62 publications

(70 reference statements)

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“…The results show innumerous negative outcomes for newborn health. Concerning the common physiological outcomes, low birth weight (Aghamohammadi & Zafari, 2016;Bateman, Ng, Hansen, & Heagarty, 1993;Behnke et al, 2001;Bender et al, 1995;R Cherukuri, Minkoff, Feldman, A, & Glass, 1988;Radha Cherukuri, Howard, Parekh, Feldman, & Glass, 1987;Fiocchi & Kingree, 2001;Leblanc, 1987;Mardini et al, 2016Mardini et al, , 2017Parcianello et al, 2018;Sprauve, Lindsay Michael K., Herbert, & Graves, 1997;Zavaschi et al, 2014) preterm delivery (Aghamohammadi & Zafari, 2016;Bateman et al, 1993;Behnke et al, 2001;R Cherukuri et al, 1988;Radha Cherukuri et al, 1987;Eyler et al, 1998;Fiocchi & Kingree, 2001;Leblanc, 1987;Reis & Loureiro, 2015;Sprauve et al, 1997;Xavier et al, 2017) and small for gestational age (Behnke et al, 2001;Leblanc, 1987;Reis & Loureiro, 2015) were well establish risk between newborn exposure to crack cocaine during pregnancy (dos Santos et al, 2018). The low 5-minute Apgar score (Parcianello et al, 2018;Sprauve et al, 1997) and small head circunference (Behnke et al, 2001;R Cherukuri et al, 1988;Radha Cherukuri et al, 1987;Leblanc, 1987) were also reported as a risk to crack cocaine exposure.…”

Section: Discussionmentioning

confidence: 99%

Newborn outcomes exposure to crack cocaine during pregnancy: a critical review

Silveira

Santos

Tavella

et al. 2020

BJD

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Crack cocaine is a psychotropic and neurotoxic drug with high prevalence of consumption, considerate a public health problem and identified as risk factors to human health. Crack cocaine use among women in reproductive age increased in few year and the literature of the neonatal exposure to this substance during pregnancy are limited. Thus, this critical review discusses the major newborn outcomes reported in original studies, highlighting neurologic abnormalities and malformations outcomes. Sixteen studies were included in this review. The main physiological outcome found in newborn exposure to crack cocaine during gestation were lower birth weight; preterm birth; growth restricted infants; lower 5-minute Apgar scores; small for gestational age; and, small head circumference and congenital malformations. There were several negative neurologic and outcomes were reported on the literature. Moreover, there were still no consensus and the main criticism in this area is the limited studies available. RESUMOO crack é uma droga psicotrópica e neurotóxica, com alta prevalência de consumo, considerado um problema de saúde pública e tido como fator de risco para a saúde humana. O uso de crack entre mulheres em idade reprodutiva aumentou em poucos anos e a literatura sobre a exposição neonatal a essa substância durante a gravidez é limitada. Assim, esta revisão crítica discute os principais desfechos neonatais relatados em estudos originais, destacando como desfechos as anormalidades neurológicas e as malformações. Dezesseis estudos foram incluídos nesta revisão. Os principais desfechos fisiológicos encontrados na exposição do recém-nascido ao crack durante a gestação foram menor peso ao nascer; nascimento prematuro; restrição de crescimento; menores escores de Apgar no 5º minuto; pequeno para a idade gestacional; menor circunferência da cabeça e malformações congênitas. Houve vários desfechos neurológicos negativos e os resultados foram relatados na literatura. Ainda assim, não houve consenso na literatura e as principais críticas nesta área são os limitados estudos disponíveis.Palavras-chave: drogas ilícitas, gestação, recém-nascido.

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Section: Discussionmentioning

confidence: 99%

Newborn outcomes exposure to crack cocaine during pregnancy: a critical review

Silveira

Santos

Tavella

et al. 2020

BJD

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“…A exposição pré-natal à cocaína também está associada a alterações neurocomportamentais durante a infância e a adolescência. A dependência de cocaína gera um estado de estresse crônico e a manutenção desse estresse provoca mudanças no equilíbrio das citocinas (MARDINI et al, 2016).…”

Section: )unclassified

“…O estresse crônico leva à ativação do eixo hipotalâmicopituitário -adrenal, eixo do sistema nervoso simpático e fibras do nervo vago, provocando a secreção de glicocorticóides, catecolaminas e acetilcolina, perturbando a homeostase das citocinas. As IL-6 e IL-10 podem ser biomarcadores precoces da exposição pré-natal a cocaína em recém-nascidos (MARDINI et al, 2016). Esses resultados podem ajudar a elucidar as vias neurobiológicas subjacentes a alterações do desenvolvimento e aumentar a gama de possibilidades para intervenção precoce.…”

Section: )unclassified

“…Devemos nos atentar à dificuldade na distinção de quais consequências neurocomportamentais são referentes à exposição pré-natal a cocaína e quais são relacionadas a outras condições adversas. Recém-nascidos expostos à cocaína estão em ambientes de maior risco e experimentam cuidados instáveis (MARDINI et al, 2016), para tanto, a identificação dos marcadores neurobiológicos mais próximos do tempo de exposição intrauterina pode auxiliar a elucidação da problemática.…”

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O uso de drogas ilícitas na gravidez e as consequências para a mãe e para o feto

Balestra

Magalhães

Teixeira

et al. 2020

BJD

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The use of illicit drugs in pregnancy is a matter of concern. The substances contained in different types of illicit drugs have consequences for the mother and fetus in the prenatal period and for the newborn in the postnatal period. It is well known that the increasing ease of access to drugs has been increasing in quantity and severity the maternal-fetal consequences. This paper aims to emphasize the importance of the clinical, epidemiological and pathophysiological aspects of the use of illicit drugs during pregnancy through an integrative literature review. The The review was broght out from twenty past research in the Scielo, Medline and PubMed databases. After assessing the prevalence and severity of complications, we decided to focus on three main drugs: crack, cocaine and marijuana. From the analysis of the articles, it was concluded that marijuana is the drug with the highest prevalence of use and that cocaine and its derivatives (crack) cause abundant maternal-fetal changes.

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“…Clinical Studies. Newborns whose mothers used crack or cocaine during pregnancy have elevated inflammation in umbilical cord blood compared to control children, even after adjusting for maternal psychopathology, sociodemographic factors, and nicotine consumption ( Mardini et al, 2016 ). Maternal alcohol consumption during pregnancy increases the risk for infection during early childhood due to alcohol-induced reductions in immune responses to antigens ( Pasala et al, 2015 ).…”

Section: Hpa Axis and The Immune Systemmentioning

confidence: 99%

Neuroendocrine and immune pathways from pre- and perinatal stress to substance abuse

Horn

Roos

Berkman

et al. 2018

Neurobiology of Stress

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Early life adversity is a documented risk factor for substance abuse and addiction. The pre- and perinatal period (i.e., from implantation, through pregnancy, to 6 months of age) is a critical period marked by high biological plasticity and vulnerability, making perinatal stress a particularly robust form of adversity. The neuroendocrine and immune systems are key mechanisms implicated in the transmission of addiction risk. We review animal and human studies that provide preliminary evidence for links between perinatal stress, neuroendocrine and immune dysregulation, and risk for substance abuse and addiction. A translational neuroscience perspective is employed to elucidate pre- and perinatally-induced biological mechanisms linked to addiction and discuss implications for prevention and intervention efforts. Significant evidence supports associations between pre- and perinatal stress and dysregulation of the hypothalamic-pituitary-adrenal axis and immune systems as well as links between neuroendocrine/immune functioning and addiction risk. More work is needed to explicitly examine the interplay between pre- and perinatal stress and neuroendocrine/immune disruptions that together heighten substance abuse risk. Future work is needed to fully understand how pre- and perinatal stress induces biological alterations to predispose individuals to higher risk for addiction. Such knowledge will strengthen theoretically-driven and empirically-supported prevention efforts for substance abuse and addiction.

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IL-6 and IL-10 levels in the umbilical cord blood of newborns with a history of crack/cocaine exposure in utero: a comparative study

Abstract: IL-6 and IL-10 might be early biomarkers of PCE in newborns. These findings could help to elucidate neurobiological pathways underlying neurodevelopmental changes and broaden the range of possibilities for early intervention.

Cited by 8 publications

References 62 publications

Newborn outcomes exposure to crack cocaine during pregnancy: a critical review

Newborn outcomes exposure to crack cocaine during pregnancy: a critical review

O uso de drogas ilícitas na gravidez e as consequências para a mãe e para o feto

Neuroendocrine and immune pathways from pre- and perinatal stress to substance abuse

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