2015
DOI: 10.1590/2237-6089-2015-0017
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Abstract: Objective:To investigate the effects of ethanol exposure in adolescent rats during adulthood by assesssing aggression and anxiety-like behaviors and measuring the levels of inflammatory markers.Methods:Groups of male Wistar rats (mean weight 81.4 g, n = 36) were housed in groups of four until postnatal day (PND) 60. From PNDs 30 to 46, rats received one of three treatments: 3 g/kg of ethanol (15% w/v, orally, n = 16), 1.5 g/kg of ethanol (12.5% w/v, PO, n = 12), or water (n = 12) every 48 hours. Animals were a… Show more

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Cited by 24 publications
(4 citation statements)
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“…As mentioned earlier, Feng and colleagues showed that ethanol exposure from GD 5-20 reduced cortical and hippocampal BDNF when evaluated on PND7-8 (Feng et al, 2005). Our finding confirmed previous studies that demonstrated BDNF levels reduced following ethanol exposure in the hippocampus (Feng et al, 2005;Jain et al, 2013;Scheidt et al, 2015).…”
Section: Olm Testsupporting
confidence: 91%
“…As mentioned earlier, Feng and colleagues showed that ethanol exposure from GD 5-20 reduced cortical and hippocampal BDNF when evaluated on PND7-8 (Feng et al, 2005). Our finding confirmed previous studies that demonstrated BDNF levels reduced following ethanol exposure in the hippocampus (Feng et al, 2005;Jain et al, 2013;Scheidt et al, 2015).…”
Section: Olm Testsupporting
confidence: 91%
“…One suggestion is the suppression of neurotrophins, such as brain-derived neurotrophic factor (BDNF), which is a regulator of the survival and differentiation of newly generated neurons. Adolescent alcohol use appears to decrease BDNF expression in the hippocampus and interrupts neurogenesis (132)(133)(134)(135). Further evidence of the role of BDNF in neurogenesis disruption comes from a study where a BDNF agonist was administered to male rodents previously exposed to alcohol (133).…”
Section: Novel Rodent Findingsmentioning
confidence: 99%
“…In addition, several studies suggested that a decreased of BDNF activity may be involved in ethanol-induced neurodegeneration and in the etiology of ethanol-related neurodevelopmental disorders. Therefore, as BDNF deficiency, especially in the hippocampus structure, affects the processes of spatial learning and memory, this effect may explain our experimental outcomes [ 78 , 79 , 80 ]. In addition, the long-lasting impairment that was noted may also be related to the lack of tolerance to the neurotoxic effects of ethanol, as well as permanent damage to the hippocampus area after its administration during adolescence.…”
Section: Discussionmentioning
confidence: 99%