Serum insulin-like growth factor-1 levels in females and males in different cervical vertebral maturation stages

Abstract

OBJECTIVE: The aim of this cross sectional study was to assess serum insulin-like growth factor-1 (IGF-1) levels in female and male subjects at various cervical vertebral maturation (CVM) stages. MATERIAL AND METHODS: The study sample consisted of 60 subjects, 30 females and 30 males, in the age range of 8-23 years. For all subjects, serum IGF-1 level was estimated from blood samples by means of chemiluminescence immunoassay (CLIA). CVM was assessed on lateral cephalograms using the method described by Baccetti. Serum IGF-1 level and cervical staging data of 30 female subjects were included and taken from records of a previous study. Data were analyzed by Kruska-Wallis and Mann Whitney test. Bonferroni correction was carried out and alpha value was set at 0.003. RESULTS: Peak value of serum IGF-1 was observed in cervical stages CS3 in females and CS4 in males. Differences between males and females were observed in mean values of IGF-1 at stages CS3, 4 and 5. The highest mean IGF-1 levels in males was observed in CS4 followed by CS5 and third highest in CS3; whereas in females the highest mean IGF-1 levelswas observed in CS3 followed by CS4 and third highest in CS5. Trends of IGF-1 in relation to the cervical stages also differed between males and females. The greatest mean serum IGF-1 value for both sexes was comparable, for females (397 ng/ml) values were slightly higher than in males (394.8 ng/ml). CONCLUSIONS: Males and females showed differences in IGF-1 trends and levels at different cervical stages.

IDENTIFICATION OF SNPs IGF-1 GENE IN VERTICAL MANDIBULAR ASYMMETRY PATIENTS WITH IDIOPATHIC SCOLIOSIS SYMPTOM

“…There was a significant difference in trends and levels of IGF-1 at different cervical stages for both sexes [25][26][27]. The combination of level IGF-1 and the presence of mandibular length due to abnormal growth in condylar hyperplasia can affect dentocraniofacial development in adolescents [26,27]. Our result showed a significant difference of IGF-1 level between early and late adolescent ( Table 3).…”

“…IGF-1 serum levels have been an additional tool to optimize the timing of orthodontic treatment. There was a significant difference in trends and levels of IGF-1 at different cervical stages for both sexes [25][26][27]. The combination of level IGF-1 and the presence of mandibular length due to abnormal growth in condylar hyperplasia can affect dentocraniofacial development in adolescents [26,27].…”

“…Unraveling the genetic contributions for both conditions can help to provide improved genetic counseling, prevention, and treatment strategies for this phenotype [6]. Some studies reported that the benefits of early detection of IGF-1 gene might be as one of the principal mediators in promoting muscular and skeletal growth to optimize the timing of orthodontic treatment, indeed in orthopaedic treatment [25][26][27]. Even though this study showed a non-significant association between IGF-1 level and any of the SNP (rs5742632), the chronological age might be a reliable indicator for skeletal maturity concurrently with IGF-1 level assessment in vertical mandibular asymmetry and scoliosis symptom (Table 3).…”

Klasszikus és modern vizsgálómódszerek a csontérettségi kor és a pubertáskori növekedési csúcs meghatározására

“…Ezzel szemben az inzulinszerű növekedési faktor-1 (IGF1) termelődését a GH stimulálja, továbbá a GH hatásának elsődleges mediátora -szintje nem fluktuál úgy, mint a GH-é, így sokkal megbízhatóbb módszernek mutatkozik [44]. Számos munkacsoport végzett vizsgálatokat, hogy a szérum-IGF1 (seIGF1) és a radiológiai módszerekkel mért szkeletális korok közötti összefüggésekből következtessenek a növekedés ütemére [44][45][46][47][48]. Ishaq és mtsai szoros korrelációt találtak az egyes csigolyaérettségi stádiumok és a seIGF1 között.…”

“…Továbbá a vizeletvizsgálat legnagyobb előnye, hogy a mintavétel noninvazív [46]. A mások által publikált eredmények annyiban különböznek, hogy a két nem közötti különbségek jobban megmutatkoztak, mivel a lányoknál a 3., míg fiúknál a 4. csigolyaérettségi korban mérték a legmagasabb IGF1-értékeket [46,47]. Összességében elmondható, hogy a mért IGF1-szintek tendenciái hasonlók (IGF1-növekedés, -csúcs, majd -csökkenés), továbbá egyetértés van a tekintetben is, hogy a lányok esetén a növekedési csúcs korábbra tehető.…”