Differences between COVID-19-induced acute kidney injury and chronic kidney disease patients

Abstract

Introduction: This article describes the main differences between COVID-19-induced acute kidney injury (AKI-COVID19) in patients with previous normal renal function (AKI-NRF) and those with chronic kidney disease (AKI-CKD) treated in a high complexity clinic in Barranquilla (Colombia). Material and Methods: The patients included in this study (n: 572) were those with a positive diagnosis of COVID-19 confirmed by detection of a positive PCR for SARS-CoV-2. Of these patients, 188 developed AKI during their hospital stay. Patients’ epidemiological data, serum parameters, and clinical frailty status were recorded. Statistical analysis and comparison among AKI-NRF, AKI-CKD, and non-AKI patients were performed. Results: The incidence of COVID-19-induced AKI was 33%, with the majority classified as AKIN 1, 16% requiring renal replacement therapy, and AKI-COVID19 mortality of 68%. A significantly higher prevalence of hypertension, cardiac disease, and serum reactive C-protein and lower albumin values in AKI-CKD patients was recorded. Mortality rate, invasive ventilation requirement, and D-dimer levels were significantly higher in AKI-NRF patients: Conclusion: Different clinical patterns between AKI-NRF and AKI-CKD were documented.

Síndrome nefrótico secundario a podocitopatía en infección por SARS-COV2

“…In December 2019 the world witnessed the onset and dissemination of a novel infectious disease, coronavirus disease or COVID-19 -caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 virus) -which quickly emerged into a pandemic on a colossal scale [1]. Since then, it has been understood that COVID-19 can have various clinical presentations, ranging from asymptomatic to systemic manifestations.…”

Assessment of kidney functions among COVID-19 patients in Isolation Center, Zawia-Libya

“…A wide range of renal problems, including albuminuria (34%), hematuria (27%), proteinuria (63%), and proteinuria with hematuria (44%), are also included in the survey. 8 kidney injury induced by COVID-19 has been linked to numerous pathways. The virus's directly negatively impacts podocytes, endothelial cells, and tubular cells whereas others result from reduced perfusion (shock), pigmenturia (rhabdomyolisis), microangiopathy (disseminated intravascular coagulation), hypoxia (respiratory insufficiency), immunological renal damage (cytokine storm), and drug toxicity.…”

Lesão renal aguda induzida por COVID-19 e doença renal crônica: comentário

“…Caro Editor, Gostaríamos de comentar o artigo intitulado "Diferenças entre pacientes com lesão renal aguda induzida por COVID-19 e pacientes com doença renal crônica" 1 . De acordo com Aroca-Martínez et al 1 , pacientes com LRA-FRN apresentaram taxas de mortalidade consideravelmente mais elevadas, maior necessidade de ventilação invasiva e níveis mais altos de D-dímero. Ambos concordamos que a COVID-19 pode resultar em problemas renais.…”