2020
DOI: 10.1590/1984-3143-ar2020-0069
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Abstract: Reproductive efficiency is critically dependent on embryo survival, establishment of a successful pregnancy and placental development. Recent advances in gene editing technology have enabled investigators to use gene knockdown and knockout approaches to better understand the role of hormone signaling in placental function and fetal growth and development. In this review, an overview of ruminant placentation will be provided, including recent data highlighting the role of histone lysine demethylase 1A and andro… Show more

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Cited by 5 publications
(8 citation statements)
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“…A review of ruminant placenta gene targeting found histone lysine demethylase 1A and androgen signaling involved in gene networks for cell proliferation and angiogenesis (Hord et al, 2020). The authors also note previous studies that have examined exposure to testosterone during pregnancy leading to ovarian dysfunction and low-birth-weight for female offspring suggesting that increased androgen signaling dysregulates fetal development for female offspring (Hord et al, 2020). Five genes in the minor histocompatibility antigen gene family were also upregulated in term male placentas.…”
Section: Discussionmentioning
confidence: 99%
“…A review of ruminant placenta gene targeting found histone lysine demethylase 1A and androgen signaling involved in gene networks for cell proliferation and angiogenesis (Hord et al, 2020). The authors also note previous studies that have examined exposure to testosterone during pregnancy leading to ovarian dysfunction and low-birth-weight for female offspring suggesting that increased androgen signaling dysregulates fetal development for female offspring (Hord et al, 2020). Five genes in the minor histocompatibility antigen gene family were also upregulated in term male placentas.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, DHEA and T, mostly from fetal gonads, serve as precursors for E2 synthesis, forming a true feto–placental unit [ 8 ]. Finally, maternal serum levels of testosterone nearly tripled, reaching ~0.11 ng/mL near term, in pregnant sheep [ 9 ].…”
Section: Androgens and Pregnancymentioning
confidence: 99%
“…Examples of co-regulatory proteins are histone lysine demethylases (KDMs), which bind AR and modulate the transcriptional activity of AR-target genes. In sheep placentomes, for example, KDMs have been found to act as binding partners and co-regulators of AR in trophoblast cells [ 9 , 22 ]. This interaction of AR with KDM’s leads to the demethylation of specific lysine residues on histone tails, thereby leading to either transcriptional activation or repression, depending on the specific lysine modification.…”
Section: Androgen Signaling: Genomic and Non-genomic Signaling Pathwaysmentioning
confidence: 99%
“…Exons 2 and 3 encode two distinct zinc-fingers (DNA-binding domain) required for interaction with a palindromic androgen response elements (ARE) of the core sequence, 5′-TGTTCT-3′, separated by 3 nucleotides located within the promoter regions of AR target genes. The remaining exons encode a hinge region which contains the nuclear localization signal, and the ligand binding domain [23].…”
Section: Androgen Signaling and Placenta Functionmentioning
confidence: 99%
“…Studies on ovine placentas revealed vascular endothelial growth factor A (VEGFA) expression to be androgen responsive, and androgens are thought to regulate the expression of VEGFA and play a key role in placental angiogenesis [21,23]. More specifically, AR and the KDM1A coregulator are recruited to an ARE in the ovine VEGFA promoter.…”
Section: Androgen Signaling and Placenta Functionmentioning
confidence: 99%