2020
DOI: 10.1590/1984-3143-ar2019-0115
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Abstract: Domestic and wild goats are very susceptible animals to predation, specially when pregnancy occurs. This study aimed to evaluate the use of goat fetal ovarian tissue for vitrification followed by xenotransplantation and fresh xenotransplantation in two immunosuppressed mice models (C57BL/6 SCID and Balb-C NUDE). Goat fetus ovaries were collected in slaughterhouses, divided into small cortical pieces and were destined for fresh xenotransplantation (FX) and cryopreservation followed by xenotransplantation (CX). … Show more

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Cited by 3 publications
(2 citation statements)
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References 44 publications
(49 reference statements)
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“…Subjecting one group of (non-threatened) animals (typically immunodeficient and sterilized mice or their equivalent) to highly invasive surgery, such as inserting testicular cell aggregates or cell cultures beneath the kidney capsule, is ethically dubious if the objective is to protect a different group of animals, even though they may be considered to be at heightened risk of extinction (see [ 129 , 133 , 134 , 135 ] for examples of these techniques). Careful ethical justification is needed when proposing such steps for species conservation, including the valid statistically based reassurance that the offspring are not adversely affected because of the varied technologies required.…”
Section: Stem Cells Conservation and Ethicsmentioning
confidence: 99%
“…Subjecting one group of (non-threatened) animals (typically immunodeficient and sterilized mice or their equivalent) to highly invasive surgery, such as inserting testicular cell aggregates or cell cultures beneath the kidney capsule, is ethically dubious if the objective is to protect a different group of animals, even though they may be considered to be at heightened risk of extinction (see [ 129 , 133 , 134 , 135 ] for examples of these techniques). Careful ethical justification is needed when proposing such steps for species conservation, including the valid statistically based reassurance that the offspring are not adversely affected because of the varied technologies required.…”
Section: Stem Cells Conservation and Ethicsmentioning
confidence: 99%
“…To date, although over 130 babies as of June 2017 ( Lotz et al 2020 ) and probably more than 200 in 2020 ( Dolmans et al 2020 ) have been born after the use of frozen-warmed tissue for OTT procedures in humans, this technique is still considered an innovative treatment that requires refinement. To become an effective technique, the OTT should, ideally, provide a sustainable number of high-quality oocytes from profitable ( Pimentel et al 2020 ) or endangered animals ( Comizzoli & Wildt 2013 ). Additionally, the OTT must use preferential animal models with 'dual-purpose and dual-benefit' that are able to improve clinical trials for human reproductive medicine ( Langbeen et al 2016 ).…”
Section: Introductionmentioning
confidence: 99%