Blood Cells Profile in Umbilical Cord of Late Preterm and Term Newborns

Rolim, Anna Carolina Boni; Lambert, Marley Aparecida; Borges, Juliana Policastro Grassano; Abbas, Samira Ali; Bordin, José Orlando; Langhi, Dante Mário; Chiba, Akemi Kuroda; Santos, Amélia Miyashiro Nunes dos

doi:10.1590/1984-0462/;2019;37;3;00008

Cited by 9 publications

(9 citation statements)

References 29 publications

(29 reference statements)

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“…In our study, there was no correlation between PLT and gestational age or birth weight. On the other hand, Rolim et al [16] evaluated hematologic profile in 2662 newborns including 193 late preterm, and showed that platelets remained nearly constant during gestation. These variations can be explained by differences in patient characteristics and sample size.…”

Section: Discussionmentioning

confidence: 99%

Effect of perinatal factors on platelet indices in late preterm and term newborns

Üstün

2021

Journal of Contemporary Medicine

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This study aimed to compare platelet indices between late preterm and term newborns, and to analyze their relationship with perinatal conditions. Material and Method: Ninety-eight late preterm and 102 term newborns admitted to the neonatal intensive care unit between 2018 and 2020 were retrospectively evaluated. Platelet indices including platelet count (PLT), mean platelet volume (MPV), plateletcrit (PCT), and platelet distribution width (PDW) were measured in blood samples taken on the first day of life. Results: There was no significant difference in the PLT, MPV, PCT, and PDW values between late preterm and term newborns. In late preterm newborns, multivariable analysis showed that maternal hypertension was significantly related to lower PLT (p=0.001). In term newborns, multivariable analysis showed that being small for gestational age (SGA), male sex, and maternal hypertension were significantly related to lower PLT (p<0.001, p=0.001 and p=0.017, respectively). In addition, SGA and male sex were related to lower PCT (p=0.001). In all studied patients, MPV was significantly different between infants with and without prolonged rupture of membrane (PROM) (9.8 fL vs. 9.2 fL, p=0.001). Conclusion:The obtained results show that various perinatal features influence the platelet indices in late preterm and term newborns.

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Section: Discussionmentioning

confidence: 99%

Effect of perinatal factors on platelet indices in late preterm and term newborns

Üstün

2021

Journal of Contemporary Medicine

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“…The differentials of preterm CB samples differed significantly from those of normal term samples, with lower neutrophils, high lymphocytes, and lower basophils percentages. In a previous study, CBC performed on preterm CB samples indicated low neutrophil counts in preterm compared to term CB samples, with no difference in lymphocyte counts between preterm and term CB samples [17].…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Morphological Assessment of Cord Blood: Normal Values and the Prevalence of Morphologically Aberrant Leukocytes

et al. 2021

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Introduction: Cord blood (CB) is becoming a valuable source for stem cells utilized in a variety of cell therapy applications, as well as for newborn diagnostics. Some parameters of the CB cellular components can be provided by automated analyzers, while others, such as immature or aberrant cells, require blood film morphological assessment. The objectives of the study were to establish normal CB morphology, and to determine the prevalence of morphologically aberrant leukocytes in CB. Methods: We performed a comprehensive morphological analysis of 100 CB samples taken from healthy term and appropriate-for-gestational-age neonates born to healthy mothers, preterm neonates, neonates of diabetic mothers, and small-for-gestational-age neonates. Blood counts were assessed, and manual morphological analyses were performed by laboratory specialists. Results: The manual differential count of normal CB samples established the following values: 47.8±10.7% neutrophils, 31.2±9.8% lymphocytes, 10.0±4.0% monocytes, and 3.0±2.5% eosinophils, with no significant sex-related differences. Blasts were observed in 44/100 samples with an average of 0.5±0.7% per sample, and only a minor left shift was observed. There were significant populations of large granular lymphocytes (19.1±10.6% of the total lymphocytes) and morphologically aberrant lymphocytes (12.4±5.4% of the total lymphocytes) in the samples, irrespective of neonatal status. The differentials of preterm CB samples differ significantly from normal term CB samples, including the reverse of neutrophils/lymphocytes ratio, and the lack of basophils. Conclusions: Normal values and unique morphological features in the CB of neonates are described. The abundant morphologically aberrant lymphocytes in CB may represent an immature state of the immune system at birth.

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“…Just a few studies investigated gender differences in neonatal coagulation. An early study reported that female neonates had a more active thrombocytopoiesis and higher PLT than males in neonatal cord blood [29,30] ,and the gender signi cance in PLT values would be indicated after two years old [31].…”

Section: Discussionmentioning

confidence: 99%

Capillary blood reference intervals for platelet parameters in healthy full-term neonates in China

Cui

Hou

Feng

et al. 2020

Preprint

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Background No consensus has been reached on reference intervals for platelet parameters in full-term neonates. We aimed to establish neonatal capillary blood reference intervals for platelet parameters and evaluate influences of gender, gestational age and postnatal age on platelet parameters. Methods This study was implemented in 594 healthy full-term neonates from 12 to 84 hours of age, using SYSMEX XN-9000 haematology automatic analyser by means of capillary blood. Reference intervals for platelet parameters were defined by an interval of 2.5th − 97.5th percentiles. Results Capillary reference interval for platelet count was (152–464) × 109/L. No significance was found between gender-divided reference intervals for platelet parameters. The values of platelet count changed significantly across gestational age and postnatal age. Reference intervals for other platelet parameters were affected by these factors to a different extent. Conclusions We established capillary blood reference intervals for platelet parameters in the early phases after birth of full-term neonates in China for the first time.

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Blood Cells Profile in Umbilical Cord of Late Preterm and Term Newborns

Cited by 9 publications

References 29 publications

Effect of perinatal factors on platelet indices in late preterm and term newborns

Effect of perinatal factors on platelet indices in late preterm and term newborns

Comprehensive Morphological Assessment of Cord Blood: Normal Values and the Prevalence of Morphologically Aberrant Leukocytes

Capillary blood reference intervals for platelet parameters in healthy full-term neonates in China

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