“…The secondary deep fiber filter, placed in series behind the plasma separator, allows in relation to its pores size, the separation of large molecules from the rest of the plasma. Only pathogenic macromolecules (immunoglobulins, immune complexes, and others) remain trapped into the filter pores, while the purified plasma returns to the patient avoiding, in most cases, the replacement solutions [4,15]. During treatment, the cascade filter can saturate, so it can be decompressed by performing a purge of plasma waste, until a total loss of 250 mL of plasma; once this limit is exceeded, it is necessary to proceed with the early return of blood and plasma to the patient.…”