Impulsiveness and executive functions in Parkinson’s disease

Almeida, Bruna de Assis; Hamdan, Amer Cavalheiro

doi:10.1590/1980-57642018dn13-040007

Cited by 10 publications

(4 citation statements)

References 20 publications

(23 reference statements)

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“…The association of impulsivity with cognitive dysfunction in PD remains controversial. Although some reports have suggested an association between frontal lobe dysfunction and impulsivity 45 , others have suggested that impulsivity is independent of the cognitive state 46,47 . The multifaceted nature of impulsivity may explain these contradictory results.…”

Section: Discussionmentioning

confidence: 99%

Increased large-scale inter-network connectivity in relation to impulsivity in Parkinson’s disease

Koh

Kaneoke

Donishi

et al. 2020

Sci Rep

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impulsivity is a neuropsychiatric feature of parkinson's disease (pD). We investigated the pathophysiology of impulsivity in pD using resting-state functional magnetic resonance imaging (rs-fMRI). We investigated 45 patients with idiopathic PD and 21 healthy controls. Based on Barratt Impulsiveness Scale (BIS-11) score, PD patients were classified as higher (PD-HI) or lower impulsivity (pD-Li). functional connectivity (fc) between various large-scale brain networks were analysed using the conn toolbox. fc between the right frontoparietal network (fpn) and medial visual network (MVN) was significantly higher in PD-HI patients than PD-LI patients (false discovery rate [FDR]adjusted p = 0.0315). FC between the right FPN and MVN had a significant positive correlation with total BIS-11 score (FDR-adjusted p = 0.010) and the attentional impulsivity (FDR-adjusted p = 0.046) and non-planning impulsivity subscale scores (fDR-adjusted p = 0.018). On the other hand, motor impulsivity subscale score had a significant negative correlation with the FC between the defaultmode and salience networks (right supramarginal gyrus, fDR-adjusted p = 0.018; anterior cingulate cortex, fDR-adjusted p = 0.027); this trend was observed in healthy controls. The attentional and non-planning impulsivity, regarded as 'cognitive' impulsivity, may be associated with dysfunction in integration of perceptual information and flexible cognitive control in PD.

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Section: Discussionmentioning

confidence: 99%

Increased large-scale inter-network connectivity in relation to impulsivity in Parkinson’s disease

Koh

Kaneoke

Donishi

et al. 2020

Sci Rep

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“…There is no consensus in the literature on impulsiveness and PD. Relationships between impulsiveness and cognitive functions were not observed in the research by Almeida and Hamdan (2019), in which 50 people diagnosed with PD were evaluated, using the Barratt scale. In contrast, impulsive and compulsive behaviors have been described as about three times more common in PD than in healthy individuals, and this behavior may be increased due to the side effect of using specific medications for the treatment of PD (Erga, Alves, Larsen, Tysnes, & Pedersen, 2016).…”

Section: Discussionmentioning

confidence: 87%

Executive Functions in Parkinson’s Disease

et al. 2021

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The objective of this study was to investigate executive functions (EFs) in older adults with Parkinson’s disease (PD). It was a cross-sectional and comparative study, composed of 62 participants divided into PD group (n = 31; M age = 75.26; SD age = 7.26) and control group (n = 31; M age = 74.03; SD age = 6.95), aged 61 to 93 years, recruited for convenience in 5 cities in the state of Rio Grande do Sul. The instruments used were a sociodemographic data questionnaire; MMSE; GDS-15; BIS-11; verbal fluency tasks (FAS and animals), DEX; WCST-64 and FDT. Descriptive analyzes and Student’s t and Chi-square tests were used. The PD group had a lower performance in the WCST-64 and FDT tests compared to controls, indicating worse performance in tasks that required reasoning, cognitive flexibility and processing speed, in addition, showed difficulties in performing tasks that require EF (DEX).

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“…Executive functions are important abilities for physical and mental health, essential for cognitive, social, and psychological development (ALMEIDA; HAMDAN, 2019). Considered as an umbrella term, they refer to the planning, monitoring, and execution of complex actions and reflect the way the organism reacts to a series of stimuli and processes external and internal excitations (CHRISTOFOLETTI et al, 2014).…”

Section: Discussionmentioning

confidence: 99%