2018
DOI: 10.1590/1980-57642018dn12-010013
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Abstract: Spatial orientation is emerging as an early and reliable cognitive biomarker of Alzheimer’s disease (AD) pathophysiology. However, no evidence exists as to whether spatial orientation is also affected in vascular dementia (VaD).Objective: To examine allocentric (map-based) and egocentric (viewpoint-based) spatial orientation in an early stage VaD case.Methods: A spatial test battery was administered following clinical and neuropsychological cognitive evaluation.Results: Despite the patient’s complaints, little… Show more

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Cited by 16 publications
(23 citation statements)
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References 26 publications
(24 reference statements)
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“…Notably, egocentric orientation was impaired in VCI, but relatively intact in AD patient groups when controlling for age and sex. This supports findings from our vascular patient case study (Coughlan et al, 2018a) and suggests egocentric impairments indicate a more medial parietal focused change (Weniger et al, 2009) in VCI. Furthermore, the AD patient's egocentric ability remained intact which supports suggestions that MCI and earlier stage AD groups show an undisturbed egocentric orientation (Coughlan et al, 2019), which is consistent with our early-stage AD patient population (see total ACE-III score of 72.1).…”
Section: Discussionsupporting
confidence: 89%
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“…Notably, egocentric orientation was impaired in VCI, but relatively intact in AD patient groups when controlling for age and sex. This supports findings from our vascular patient case study (Coughlan et al, 2018a) and suggests egocentric impairments indicate a more medial parietal focused change (Weniger et al, 2009) in VCI. Furthermore, the AD patient's egocentric ability remained intact which supports suggestions that MCI and earlier stage AD groups show an undisturbed egocentric orientation (Coughlan et al, 2019), which is consistent with our early-stage AD patient population (see total ACE-III score of 72.1).…”
Section: Discussionsupporting
confidence: 89%
“…A previous case study by our group explored path integration in a 65-year-old male with VCI. The findings showed that the vascular patient had normal performance on allocentric orientation but a clear and isolated deficit in egocentric and heading direction sub-components of the path integration tasks (Coughlan et al, 2018a). These findings are consistent with frontoparietal network disruptions typically seen in vascular dementia patients (Beason-Held et al, 2012;Sachdev et al, 2014;van der Flier et al, 2018) and may suggest medial parietal changes imped the egocentric frame of reference and subsequent path integration.…”
Section: Introductionsupporting
confidence: 71%
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“…Paradigm overview. The VST is a sensitive and specific measure for differentiating AD from other dementia types (Coughlan et al, 2018a;Tu et al, 2017Tu et al, , 2015 and taps into i) translation from allocentric to egocentric self-reference navigation also term egocentric orientation; ii) short-term spatial memory; iii) heading direction and iv) central (vs boundary) based navigation preference. In brief, an iPad 9.7 (Apple Inc,) is used to show participants 7-14-second video clips of a moving shopping trolley in a virtual reality supermarket from the first-person perspective (Figure 1 A-C).…”
Section: Methodsmentioning
confidence: 99%