Chikungunya no Brasil: um desafio emergente

Donalísio, Maria Rita; Freitas, André Ricardo Ribas

doi:10.1590/1980-5497201500010022

Cited by 48 publications

(42 citation statements)

References 2 publications

(1 reference statement)

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“…According to the Instituto Nacional de Salud (INS) of Colombia, the first cases in Colombia appeared in the first week of August 2014; the INS reported a total of 106,592 cases in 2014 [8]. Several countries in South America have also reported cases of CHIKV; in Venezuela, more than 200 suspected cases were described, and the Ministry of Health of Brazil has reported autochthonous transmission of CHIKV in ten cities of the country [18,19].…”

Section: Discussionmentioning

confidence: 99%

Outbreak of Chikungunya virus in the north Caribbean area of Colombia: clinical presentation and phylogenetic analysis

Máttar

Miranda

Pinzón

et al. 2015

J Infect Dev Ctries

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Introduction: The Caribbean area of Colombia has been severely affected by a Chikungunya virus (CHIKV) outbreak since 2014. Methodology: The study was carried out on 100 patients during a fever outbreak from August to September 2014 in two small rural villages in the northern Caribbean area of Colombia. The molecular assays performed by reverse transcription polymerase chain reaction (RT-PCR) on acute patient sera were collected within one to five days of the appearance of symptoms. Sequence analyses were carried out based on phylogenetic analyses of genes NS1 and E2. For serological assays, 49 (49%) patients at ≥ 6 days of disease onset were tested with NovaLisa Chikungunya IgG/IgM μ-capture enzyme-linked immunosorbent assay (ELISA). Results: The main signs or symptoms associated with Chikungunya infection were arthralgia of the lower limbs (96%), fever (91%), arthralgia of the upper limbs (85%), rash (64%), and headache (57%). Ninety-four percent (46/49) of patients were positive for either IgM or IgG; the remaining three (6%) patients were seronegative. Viral loads were detected in 25 patients. Based on phylogenetic analysis of NS1 and E2, the characterization of the Colombian CHIKV indicated that it was a strain closely related to the British Virgin Islands strain and to the Asian genotype. Conclusions: This study shows the phylogenetic and clinical description of CHIKV in Colombia. The main symptoms shown were: arthralgia, fever, and rash. CHIKV sequences detected in Colombian patients were within the Asian genotype and closely related to the British Virgin Islands strain.

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Section: Discussionmentioning

confidence: 99%

Outbreak of Chikungunya virus in the north Caribbean area of Colombia: clinical presentation and phylogenetic analysis

Máttar

Miranda

Pinzón

et al. 2015

J Infect Dev Ctries

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“…Em 2014, o primeiro caso autóctone é registrado na cidade de Oiapoque, localizada no Estado do Amapá, além de Feira de Santana na Bahia (Donalisio;Freitas, 2015).…”

Section: Introductionunclassified

“…Além disso, chama atenção o fato de a poliartrite/artralgia ser simétrica, principalmente nos punhos, tornozelos e cotovelos (Donalisio;Freitas, 2015).…”

Section: Introductionunclassified

Estudo comparativo da atuação do enfermeiro no controle de dengue e febre chikungunya

et al. 2016

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ResumoO objetivo deste estudo foi analisar a atuação dos enfermeiros das Estratégias de Saúde da Família no controle de dengue e febre chikungunya nos municípios de Parnamirim e Santa Cruz/RN. Trata-se de um estudo exploratório, descritivo, com abordagem qualitativa de tratamento e análise de dados. A coleta foi realizada entre novembro e dezembro de 2015 por meio de uma entrevista gravada, voltada às questões que abordam a ação da enfermagem e sua equipe no controle de dengue e febre chikungunya no campo de atuação da ESF. Utilizou-se como método de observação dos dados a análise de conteúdo de Bardin. Após análise, houve criação de duas categorias -educação em saúde e campanhas pontuais. Na primeira, os entrevistados informaram realizar palestras educativas, mas não explicam a metodologia usada e nem a participação popular, como também a articulação com o setor de endemias da cidade para fortalecer a discussão. Na segunda, algumas ações são assistencialistas de caráter campanhista/higienista, realizadas pelos enfermeiros dos municípios em campanhas de "higienização" e "limpeza", as quais se mostram bastante presentes nas falas dos entrevistados. Há uma forte presença desse modelo enraizada tanto nas ações quanto na realização de atividades educativas, usando como metodologia a palestra. Além disso, há necessidade de se realizar mais estudos que aprofundem o tema abordado, a julgar por uma amostra pequena, especialmente no município de Parnamirim.

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“…These include other arboviruses, such as the flavivirus Saint Louis Encephalitis [11], Chikungunya fever [12, 13], Zika fever [14], leptospirosis [15, 16], visceral leishmaniasis [17], and malaria [18]. …”

Section: Introductionmentioning

confidence: 99%

Maintenance of demographic and hematological profiles in a long-lasting dengue fever outbreak: implications for management

et al. 2016

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BackgroundDengue fever (DF) outbreaks present regionally specific epidemiological and clinical characteristics. In certain medium-sized cities (100 000–250 000 inhabitants) of São Paulo State, Brazil, and after reaching an incidence of 150 cases/100 000 inhabitants (“epidemiological threshold”), clinical diagnosis indicated dengue virus (DENV) infection. During this period, other seasonally infectious diseases with symptoms and physical signs mimicking DF can simultaneously occur, with the consequential overcrowding of health care facilities as the principal drawbacks. Confirmation of clinical diagnosis of DF with serological tests may help in avoiding faulty diagnosis in patients, who might later undergo dengue hemorrhagic fever (DHF) and the dengue-shock syndrome (DSS). Furthermore, demographic and hematological profiles of patients are useful in detecting specific early characteristics associated to DF, DHF and DSS.MethodsFrom March to June, 2007, 456 patients from Marilia in northwest São Paulo State who had only been diagnosed for DF by clinical criteria, underwent serologic testing for non-structural 1 (NS1) DENV antigens. Individual results were used in comparative analysis according to demographic (gender, age) and hematological (leukocyte and platelet counts, percentage of atypical lymphocytes) profiles. Temporal patterns were evaluated by subdividing data according to time of initial attendance, using recorded variables as predictors of DENV infection in logistic regression models and ROC curves.ResultsSerologic DENV detection was positive in 70.6 % of the patients. Lower leukocyte and platelet counts were the most important factors in predicting DENV infection (respective medians DENV + = 3 715 cells/ml and DENV- = 6 760 cells/ml, and DENV + = 134 896 cells/ml and DENV- = 223 872 cells/ml). Furthermore, all demographic and hematological profiles presented a conservative temporal pattern throughout this long-lasting outbreak.ConclusionsAs consistency throughout the epidemic facilitated defining the conservation pattern throughout the early stages, this was useful for improving management during the remaining period.Electronic supplementary materialThe online version of this article (doi:10.1186/s40249-016-0177-y) contains supplementary material, which is available to authorized users.

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Chikungunya no Brasil: um desafio emergente

Cited by 48 publications

References 2 publications

Outbreak of Chikungunya virus in the north Caribbean area of Colombia: clinical presentation and phylogenetic analysis

Outbreak of Chikungunya virus in the north Caribbean area of Colombia: clinical presentation and phylogenetic analysis

Estudo comparativo da atuação do enfermeiro no controle de dengue e febre chikungunya

Maintenance of demographic and hematological profiles in a long-lasting dengue fever outbreak: implications for management

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