Role of Si Minor Addition on Glass Formation and Flow Stress Characteristics of a Zr-Based Metallic Glass

Raya, Indah; Chen, Tzu-Chia; Pranoto, Sigiet Haryo; Aravindhan, Surendar; Utyuzh, Anatolij Sergeevich; Al-Janabi, Samaher; Alkaim, Ayad F.; Danh, Nguyen Tan; Mustafa, Yasser Fakri

doi:10.1590/1980-5373-mr-2021-0245

Cited by 8 publications

(9 citation statements)

References 43 publications

(48 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The organic layer was then isolated, dried, and vaporised. A 1:2 mixture of propane and methylene dichloride was used for the recrystallization to obtain the SA1 compound [27,28]. The spectrophotometrically collected data from 1 H-and 13 C-NMR are listed and discussed in the Results and Discussion section.…”

Section: Synthesis Of the Fused Coumarin Sa2-sa7 Compoundsmentioning

confidence: 99%

Untitled

2022

J. Med. Chem. Sci.

View full text Add to dashboard Cite

This work involves the synthesis of eight novel fused coumarin compounds, which were confirmed by various spectrophotometers and then, assessed for their apoptotic-inducing and free radical-quenching activities. The pharmacokinetic parameters were evaluated in silico using pre-ADMET, a free online program. The apoptotic-inducing activity was tested against six tumorigenic cell lines. Also, their safety against normal cells was examined. The free radical-quenching activity was assessed by checking these compounds' ability to eliminate DDPT and hydroxyl moieties. Pharmacokinetic investigations showed that the synthesized fused coumarin compounds have excellent penetration across the GIT mucosa and most of them have poor penetration across the blood-brain barrier. These findings suggest good oral bioavailability along with low neurological toxicity profiles. The evaluation of the apoptotic-inducing activity revealed that all of the compounds have weaker activity as compared to the reference. Among these compounds, SA4 was the most potent one. Nevertheless, all of these new compounds had an excellent safety profile against normal cells. On the other hand, the assessment of the free radical-quenching activity of these synthesized compounds also indicated that all of them were less active than the reference. In this field, SA0 was the strongest free radical-quenching compound. From these realizations, along with the apparent safety and good pharmacokinetic characteristics in accordance with the in silico study, compounds SA4 and SA0 are considered the most promising agents. The authors hope that these new fused coumarin compounds can be utilized in the coming years for the production of new powerful drugs with apoptoticinducing and free radical-quenching potentials which can help in the battle against many diseases.

show abstract

Section: Synthesis Of the Fused Coumarin Sa2-sa7 Compoundsmentioning

confidence: 99%

Untitled

2022

J. Med. Chem. Sci.

View full text Add to dashboard Cite

show abstract

“…According to the in-silico study, the synthesized derivatives except SF0 complied with Lipinski's rule. As a result, these compounds have lower attrition rates during drug development and clinical trials, and thus have a better chance of reaching the market [64,65].…”

Section: Computer-based Pharmacokinetic Evaluationmentioning

confidence: 99%

Untitled

2022

J. Med. Chem. Sci.

View full text Add to dashboard Cite

In recent times, many researchers in pharmaceutical chemistry have been preoccupied with the quest for new potent anti-infective agents to combat antimicrobial resistance. A novel series of naphthalene-based derivatives were synthesized as part of these studies. Different spectral techniques, such as UV-Vis, FTIR, 13C-NMR, and 1H-NMR were used to affirm the synthesized compounds' chemical structures, while an ADME study was conducted to investigate their pharmacokinetics and drug-like properties. The potential of the synthesized naphthalene-based derivatives as anti-infective candidates versus pathogenic microbes was evaluated using a broth microdilution assay. These microbes involved six aerobic gram-negative bacteria, four anaerobic bacteria, and two fungi. In addition, their safety was assessed versus normal bacterial flora. From the obtained results, the authors reported the following principal outcomes: Compound SF5 revealed a significant aerobic gram-negative bactericidal impact while indicating high safety versus the non-pathological bacterial strain. Most of the synthesized naphthalene-based derivatives demonstrated outstanding potential as fungicidal candidates, but compound SF1 was the most potent one. According to ADME analysis, almost all of the synthesized derivatives have good theoretical pharmacokinetics and drug-likeness characteristics making them suitable as oral-derived agents.

show abstract

“…After 24-hour incubation time at 37 °C, bacterial growth was visually investigated, on the basis of which concentration displayed the imperceptible bacterial proliferation, the above-outlined methodological strategies were repeated using diluted quantities created based on 4, 1, 0.5, or 0.05. Eventually, the first microbiological variable named Minimum Inhibitory Concentration (Measure I) was verified [30]. By mixing 3 mL of MHB with 0.5 mL of 2nd diluted concentrations, the second microbiological variable (Measure II) was examined.…”

Section: Assessment Of the Activity Versus Aerobic Gram (-) Bacteriamentioning

confidence: 99%

Untitled

2022

J. Med. Chem. Sci.

View full text Add to dashboard Cite

Role of Si Minor Addition on Glass Formation and Flow Stress Characteristics of a Zr-Based Metallic Glass

Cited by 8 publications

References 43 publications

Untitled

Untitled

Untitled

Untitled

Contact Info

Product

Resources

About