2019
DOI: 10.1590/1809-4392201801751
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Abstract: The skin secretion from toads of the Bufonidae family has great potential in the search for new active compounds to be used as drug candidates in treating some diseases, among them cancer. In this context, this study aimed to evaluate the cytotoxic and antimutagenic activity of the parotoid gland secretion extracts of Rhinella marina and Rhaebo guttatus, as well as biochemically analyze transaminases and serum creatinine for liver and renal damage, respectively. Cytotoxicity was performed by the colorimetric m… Show more

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Cited by 10 publications
(9 citation statements)
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“…During the experimental period, the mice were administered water (control), 0.5% Tween-20 (vehicle), or various doses of the CME (8, 16 and 32 µg/ml) in a 100 µl volume per mouse per day via oral gavage for 7 or 30 days. The doses were selected based on the study by Oliveira et al (11). Aliquots were prepared in microtubes, diluted in 0.5% Tween-20 and stored at 4˚C.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…During the experimental period, the mice were administered water (control), 0.5% Tween-20 (vehicle), or various doses of the CME (8, 16 and 32 µg/ml) in a 100 µl volume per mouse per day via oral gavage for 7 or 30 days. The doses were selected based on the study by Oliveira et al (11). Aliquots were prepared in microtubes, diluted in 0.5% Tween-20 and stored at 4˚C.…”
Section: Methodsmentioning
confidence: 99%
“…Toxic activity against Plasmodium falciparum and phytopathogenic fungi has also been reported (9,10). Oliveira et al (11) observed that a methanolic extract from the parotoid gland secretion of R. guttatus exhibited both mutagenic and antimutagenic activities, indicating the need for further studies.…”
Section: Introductionmentioning
confidence: 96%
“…marina showed strong toxic effects on rat breast carcinoma (15). A previous study by Giri et al (16) reported that Indian toad skin extract (Bufo melanostictus) inhibited EAC cell growth in EACbearing mice.…”
Section: Introductionmentioning
confidence: 95%
“…All sampled animals were returned to nature after the procedure. Voucher specimens were deposited in the Biologic Collection of Meridional Amazonia -ABAM/UFMT/Sinop (R. guttatus -ABAM-H 1538 and R. marina -ABAM-H 1262) in the context of another study (Oliveira et al 2019). The secretion was extruded by manual compression of the parotoid macrogland.…”
Section: Cutaneous Secretion Extracts and Phytopathogen Isolatesmentioning
confidence: 99%