2018
DOI: 10.1590/1809-4392201704473
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Abstract: The properties of oil-resin of copaiba, Copaifera multijuga are commonly mentioned in the literature, but there are few studies on extracts from its stem bark. We evaluated the antioxidant effects of ethanolic (EE) and ethyl acetate (EA) crude stem bark extracts from copaiba and compared them to rutin in a paracetamol (PCM)-induced oxidative stress model in mice. All test comparisons differed significantly. Hepatic catalase (CAT) and glutathione-S-transferase (GST) activity decreased in the PCM group, and ther… Show more

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Cited by 8 publications
(9 citation statements)
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“…The increased activity of these enzymes in presence of oxidative stress is an adaptive response, aiming at detoxifying the organism of oxygen free radicals and prevent damage to macromolecules (Ballesteros et al 2009). The ethanolic extract of C. multijuga stem bark is rich in antioxidants, containing a high concentration (250 mg kg -1 ) of total phenols and flavonoids, more specifically phenolic compounds in the form of tannins (Pereira et al 2018). Rajeshwar et al (2005) obtained similar results with mice inoculated intraperitoneally with 2x10 6 Ehrlich tumor cells and treated for 14 days with 125 and 250 mg kg -1 methanolic extract of Mucuna pruriens (Fabaceae).…”
Section: Discussionmentioning
confidence: 89%
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“…The increased activity of these enzymes in presence of oxidative stress is an adaptive response, aiming at detoxifying the organism of oxygen free radicals and prevent damage to macromolecules (Ballesteros et al 2009). The ethanolic extract of C. multijuga stem bark is rich in antioxidants, containing a high concentration (250 mg kg -1 ) of total phenols and flavonoids, more specifically phenolic compounds in the form of tannins (Pereira et al 2018). Rajeshwar et al (2005) obtained similar results with mice inoculated intraperitoneally with 2x10 6 Ehrlich tumor cells and treated for 14 days with 125 and 250 mg kg -1 methanolic extract of Mucuna pruriens (Fabaceae).…”
Section: Discussionmentioning
confidence: 89%
“…The continuous production of free radicals during metabolic processes has led to the development of many antioxidant defense mechanisms to limit and prevent cell damage (Vasconcelos et al 2014). The antioxidants present in the C. multijuga stem bark extract (Pereira et al 2018) may be interfering in the generation of oxygen reactive species produced by the Ehrlich tumor.…”
Section: Discussionmentioning
confidence: 99%
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“…Immunomodulatory effects are also attributed to phenolic compounds and flavonoids [22][23][24]. Pereira et al [25] evaluated the antioxidant effects of C. multijuga bark ethanolic extract and observed a higher concentration of phenolic compounds, such as epicatechin and epiafzelechin-condensed tannins. Increased NK activity observed in this study may be a consequence of the condensed tannins present in C. multijuga extract since condensed tannins upregulate NK cell response [22,23].…”
Section: /8mentioning
confidence: 99%