2017
DOI: 10.1590/1809-4392201700871
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Abstract: Treatment of cutaneous leishmaniasis (CL) is difficult due to the scarce number of drugs able to eliminate completely the intracellular form of the parasite. In the present study, the aim was to evaluate: i) phytochemical properties of extracts from Libidibia ferrea; ii) antileishmanial activity of extracts from L. ferrea against promastigotes and amastigotes of Leishmania (Leishmania) amazonensis and Leishmania (Viannia) guyanensis; iii) the effects of topical treatment using hydrogel containing active extrac… Show more

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Cited by 22 publications
(16 citation statements)
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“…This result of expressive lymphoproliferation may be related to the therapeutic biological potential of the fraction of L. ferrea obtained, whose antileishmanial activity was confirmed against L. (L.) amazonensis and L. (V.) guyanensis and did not present cytotoxic effects in murine macrophages (Comandolli-Wyrepkowski et al, 2017). To date, the mechanism of action of the pharmacological components of L. ferrea in vivo is not yet known.…”
Section: Resultsmentioning
confidence: 67%
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“…This result of expressive lymphoproliferation may be related to the therapeutic biological potential of the fraction of L. ferrea obtained, whose antileishmanial activity was confirmed against L. (L.) amazonensis and L. (V.) guyanensis and did not present cytotoxic effects in murine macrophages (Comandolli-Wyrepkowski et al, 2017). To date, the mechanism of action of the pharmacological components of L. ferrea in vivo is not yet known.…”
Section: Resultsmentioning
confidence: 67%
“…Therefore, given its medical importance, the Brazilian Ministry of Health has included this species in the National List of Important Medicinal Plants for the Health System and indicates that it has analgesic, antipyretic, antiinflammatory and/or antispasmodic (Brasil, 2006), and healing and antioxidant properties (Carvalho, Sampaio, Araújo, Pinto, & Rocha, 2016;Falcão et al, 2019). Antileishmanial activity was observed by Comandolli-Wyrepkowski et al (2017), who confirmed that L. ferrea presented efficiency in the treatment of CL in in vitro and in vivo experiments. In this sense, considering the therapeutic relevance of L. ferrea, this study aimed to evaluate the action of a fraction obtained from the methanolic extract of L. ferrea on the lymphoproliferation of PBMC of people exposed to Leishmania sp.…”
Section: Introductionmentioning
confidence: 93%
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“…Meanwhile, the leaf and fruit methanol extracts showed an IC 50 activity of 129.42 and 173.11 μg·mL −1 against Leishmania ( V. ) guyanensis promastigotes. The fruit methanol extract showed low in vitro toxicity on infected macrophages, and was thus selected for antileishmanial activity tests with intracellular infected macrophages, the results of which showed the 500 μg.mL −1 concentration inhibited 62% and 54% of L. (V.) guyanensis and L. (L.) amazonensis amastigotes survival, respectively [ 80 ].…”
Section: Resultsmentioning
confidence: 99%
“…Several biological activities from the fruits and bark of L. ferrea have been reported in the literature as anti-inflammatory [6], gastric anti-ulcer [7], antidiabetic [8], healing [9], antitumor [10], anti-proliferative [11], hepatoprotective [12], antimicrobial [13], and in vitro leishmanicidal [14]. However, despite the widespread use of popular alcoholic preparations and pharmaceutical dispensing of products with derivatives of this plant species, few studies have reported the safety of these products [15][16][17], especially in an alternative model such as zebrafish.…”
Section: Introductionmentioning
confidence: 99%