2017
DOI: 10.1590/1809-4392201601333
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Abstract: Current treatment of cutaneous leishmaniasis (CL) relies mainly on pentavalent antimonials salts and second-line drugs include pentamidine and amphotericin B, but these therapies have side effects and require parenteral administration. The aim of this work was to evaluate the topical formulations containing pentamidine isethionate (PI) in the experimental treatment of cutaneous leishmaniasis (CL). Golden hamsters (Mesocricetus auratus) were infected in the nose with Leishmania (Leishmania) amazonensis. Six tre… Show more

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Cited by 3 publications
(3 citation statements)
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“…However, there was an increase, although lower than in the negative control and also in the group treated with Glucantime®, regarding the presence of parasites after 20 days without receiving treatment. Hamsters treated with a topical formulation with pentamidine also showed viable parasites after end of treatment (Comandolli-Wyrepkowski et al 2017).…”
Section: Discussionmentioning
confidence: 98%
“…However, there was an increase, although lower than in the negative control and also in the group treated with Glucantime®, regarding the presence of parasites after 20 days without receiving treatment. Hamsters treated with a topical formulation with pentamidine also showed viable parasites after end of treatment (Comandolli-Wyrepkowski et al 2017).…”
Section: Discussionmentioning
confidence: 98%
“…Information about the topical use of pentamidine was scarce. A topical application of 10% PMD isethionate and 10% usnic acid cream over eight consecutive days reduced lesion size (reduction of 27.37%) and parasite numbers in L. (L.) amazonensis -infected hamsters, compared to controls 28 . In addition, intralesional PMD isethionate (three injections of 120 μg/mm 2 to the lesion area over five days) has resulted in a cure rate of 72% for Bolivian L. (V.) braziliensis- infected patients 29 …”
Section: Discussionmentioning
confidence: 99%
“…A tissue sample sectioned from the lesion area of each animal was also used for an impression on glass slides. The slides were stained with Giemsa (Sigma), and the infectivity index was determined by multiplying the percentage of macrophages having at least one intracellular parasite by the average number of intracellular parasites per infected macrophage (at least 200 cells/animal were examined) [ 48 , 49 , 50 ].…”
Section: Methodsmentioning
confidence: 99%