Prevalence of antibodies to equine alphaviruses in the State of Pará, Brazil

Casseb, Alexandre do Rosário; Brito, Thais Costa; Silva, Maria Rogéria Menezes da; Chiang, Jannifer Oliveira; Martins, Lívia Carício; Silva, Sandro Patroca da; Henriques, Daniele Freitas; Casseb, Lívia Medeiros Neves; Vasconcelos, Pedro Fernando da Costa

doi:10.1590/1808-1657000202014

Cited by 6 publications

(5 citation statements)

References 13 publications

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“…In domestic animals, evidence of MAYV infection was detected in equids, cattle/buffalo, and dogs. Six studies assessed MAYV seroprevalence in Brazilian equids [ 58 , 61 , 67 , 78 , 89 , 90 ], and antibodies against MAYV were detected in four of these studies. Notably, Gomes et al [ 78 ] reported MAYV neutralizing antibodies in 48 equids out of 213 (23%) based on ELISA.…”

Section: Resultsmentioning

confidence: 99%

“…However, only 16 of the 48 equids were considered positive based on the study’s diagnostic criterion of 4-fold greater plaque reduction NT 90 titer than that of the other viruses under study. In addition, Casseb et al [ 67 ] detected MAYV antibodies in 40 horses using HI, although only four of the 40 reactions were monotypic, and confirmatory NTs were not performed. Additional domestic animals with evidence of MAYV infection included cattle/buffalo (n = 14/1103 positive reactions by HI; 5/14 monotypic reactions [ 66 ]) and dogs (n = 2/7 positive reactions by HI [ 57 ]).…”

Section: Resultsmentioning

confidence: 99%

“…Domestic and sentinel animals with evidence of MAYV positivity are reported in Table 6 and complete results are reported in the S3 Table . In domestic animals, evidence of MAYV infection was detected in equids, cattle/buffalo, and dogs. Six studies assessed MAYV seroprevalence in Brazilian equids [58,61,67,78,89,90], and antibodies against MAYV were detected in four of these studies. Notably, Gomes et al [78]…”

Section: Mayv In Domestic or Sentinel Animalsmentioning

confidence: 99%

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A systematic review and meta-analysis of the potential non-human animal reservoirs and arthropod vectors of the Mayaro virus

et al. 2021

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Improving our understanding of Mayaro virus (MAYV) ecology is critical to guide surveillance and risk assessment. We conducted a PRISMA-adherent systematic review of the published and grey literature to identify potential arthropod vectors and non-human animal reservoirs of MAYV. We searched PubMed/MEDLINE, Embase, Web of Science, SciELO and grey-literature sources including PAHO databases and dissertation repositories. Studies were included if they assessed MAYV virological/immunological measured occurrence in field-caught, domestic, or sentinel animals or in field-caught arthropods. We conducted an animal seroprevalence meta-analysis using a random effects model. We compiled granular georeferenced maps of non-human MAYV occurrence and graded the quality of the studies using a customized framework. Overall, 57 studies were eligible out of 1523 screened, published between the years 1961 and 2020. Seventeen studies reported MAYV positivity in wild mammals, birds, or reptiles and five studies reported MAYV positivity in domestic animals. MAYV positivity was reported in 12 orders of wild-caught vertebrates, most frequently in the orders Charadriiformes and Primate. Sixteen studies detected MAYV in wild-caught mosquito genera including Haemagogus, Aedes, Culex, Psorophora, Coquillettidia, and Sabethes. Vertebrate animals or arthropods with MAYV were detected in Brazil, Panama, Peru, French Guiana, Colombia, Trinidad, Venezuela, Argentina, and Paraguay. Among non-human vertebrates, the Primate order had the highest pooled seroprevalence at 13.1% (95% CI: 4.3–25.1%). From the three most studied primate genera we found the highest seroprevalence was in Alouatta (32.2%, 95% CI: 0.0–79.2%), followed by Callithrix (17.8%, 95% CI: 8.6–28.5%), and Cebus/Sapajus (3.7%, 95% CI: 0.0–11.1%). We further found that MAYV occurs in a wide range of vectors beyond Haemagogus spp. The quality of evidence behind these findings was variable and prompts calls for standardization of reporting of arbovirus occurrence. These findings support further risk emergence prediction, guide field surveillance efforts, and prompt further in-vivo studies to better define the ecological drivers of MAYV maintenance and potential for emergence.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Mayv In Domestic or Sentinel Animalsmentioning

confidence: 99%

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A systematic review and meta-analysis of the potential non-human animal reservoirs and arthropod vectors of the Mayaro virus

et al. 2021

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“…A single case of encephalitis by EEEV was reported in Bahia, Northeast Brazil, in the 1950s [ 172 ]. No human case of WEEV has been diagnosed in Brazil to date, but serological evidence is frequently reported in wild and domestic animals [ 173 ]. MAYV is an important epidemic agent in the north and central-west regions of Brazil, but cases associated with neurological disease are rare or absent [ 174 ].…”

Section: Viruses Commonly Associated With Cns Infection In Brazilmentioning

confidence: 99%

Viral and Prion Infections Associated with Central Nervous System Syndromes in Brazil

Sousa

Santos

Paula

et al. 2021

Viruses

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Virus-induced infections of the central nervous system (CNS) are among the most serious problems in public health and can be associated with high rates of morbidity and mortality, mainly in low- and middle-income countries, where these manifestations have been neglected. Typically, herpes simplex virus 1 and 2, varicella-zoster, and enterovirus are responsible for a high number of cases in immunocompetent hosts, whereas other herpesviruses (for example, cytomegalovirus) are the most common in immunocompromised individuals. Arboviruses have also been associated with outbreaks with a high burden of neurological disorders, such as the Zika virus epidemic in Brazil. There is a current lack of understanding in Brazil about the most common viruses involved in CNS infections. In this review, we briefly summarize the most recent studies and findings associated with the CNS, in addition to epidemiological data that provide extensive information on the circulation and diversity of the most common neuro-invasive viruses in Brazil. We also highlight important aspects of the prion-associated diseases. This review provides readers with better knowledge of virus-associated CNS infections. A deeper understanding of these infections will support the improvement of the current surveillance strategies to allow the timely monitoring of the emergence/re-emergence of neurotropic viruses.

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“…Studies have suggested that South and Central America OROV has two distinct transmission cycles: sylvatic and urban. In the first, the transmission occurs between its insect vectors and wild host such as birds and mammals like Proechimys sp., Bradypus tridactulus, Allouatta caraya, and Callithrix penicillata (50,60,61). During this cycle, the virus is transmitted by vector culicids such as Aedes serratus and Coquillettidia venezuelensis, from which OROV has been isolated in the Brazilian Amazon region and Trinidad, respectively (62)(63)(64)66).…”

Section: Vectors and Reservoir Hostsmentioning

confidence: 99%

Emergent Arboviruses: A Review About Mayaro virus and Oropouche orthobunyavirus

Pereira¹,

Virginio

Souza³

et al. 2021

Front. Trop. Dis

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Arthropod-borne viruses have a significant impact on public health worldwide, and their (re) emergence put aside the importance of other circulating arboviruses. Therefore, this scoping review aims to identify and characterize the literature produced in recent years, focusing on aspects of two arboviruses: Mayaro virus and Oropouche orthobunyavirus. The Mayaro and Oropouche viruses were isolated for the first time in Trinidad and Tobago in 1954 and 1955, respectively, and have more recently caused numerous outbreaks. In addition, they have been incriminated as candidate diseases for human epidemics. These viruses have been drawing the attention of public health authorities worldwide following recent outbreaks. To determine the global epidemiological profile of these viruses, we used the Dimensions Database, which contains more than 100 million publications. In general, we identified 327 studies published from 1957 to 2020 for Mayaro virus, and 152 studies published from 1961 to 2020 for Oropouche orthobunyavirus. Interestingly, we observed that Mayaro and Oropouche had a significant increase in the number of publications in recent years. Thus, this comprehensive review will be helpful to guide future research based on the identified knowledge gaps.

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Prevalence of antibodies to equine alphaviruses in the State of Pará, Brazil

Cited by 6 publications

References 13 publications

A systematic review and meta-analysis of the potential non-human animal reservoirs and arthropod vectors of the Mayaro virus

A systematic review and meta-analysis of the potential non-human animal reservoirs and arthropod vectors of the Mayaro virus

Viral and Prion Infections Associated with Central Nervous System Syndromes in Brazil

Emergent Arboviruses: A Review About Mayaro virus and Oropouche orthobunyavirus

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