2018
DOI: 10.1590/1807-3107bor-2018.vol32.0004
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Abstract: Radiation combined injury, a life-threatening condition, has higher mortality than simple radiation injury. The aim of the present study was to analyze the efficiency of Aloe vera and silver nanoparticles in improving the healing of ulcerated oral mucosa after irradiation. Thirty male Albino mice were divided into five groups: control, radiation, Aloe vera (AV), silver nanoparticles (NS), and AV+NS. The mice were exposed to whole body 6Gy gamma-radiation. After one hour, 20% acetic acid was injected into the s… Show more

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Cited by 25 publications
(18 citation statements)
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“…While many studies had tested the effectiveness of many substances to treat oral ulcers, an established standardized experimental model of oral ulcer was still lacking. 5,9 This study has proven that by applying acetic acid at a specific duration using a standardized tool (microbrush ® ) provides reproducible results.…”
Section: Discussionmentioning
confidence: 89%
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“…While many studies had tested the effectiveness of many substances to treat oral ulcers, an established standardized experimental model of oral ulcer was still lacking. 5,9 This study has proven that by applying acetic acid at a specific duration using a standardized tool (microbrush ® ) provides reproducible results.…”
Section: Discussionmentioning
confidence: 89%
“…The acetic acid model has been previously used in peptic ulcer model. 9 Acetic acid is a common chemical agent used to induce inflammation/ulcers of various tissues and organs with different concentrations and methods being introduced from previous reports. 3,4,13,14 This study using the application of 70% acetic acid to induce inflammation offers a practical and straightforward method to create ulceration.…”
Section: Discussionmentioning
confidence: 99%
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“…It was proven that each of the silver nanoparticles and curcumin has an antimicrobial action when used alone (14)(15)(16)(17)(18)(19)(20)(21)(22)(23) , Therefore we combined both materials to increase the antimicrobial action of curcumin and decrease the toxicity of silver nanoparticles that was demonstrated in previous studies (35)(36)(37)(38)(39) .…”
Section: Discussionmentioning
confidence: 98%
“…Silver nanoparticles possess antibacterial and antifungal properties through the release of Ag + ions which increases the permeability of bacterial cell wall causing damage to the bacterial cytoplasm and DNA (22,23) .…”
Section: Introductionmentioning
confidence: 99%