Gingival crevicular fluid oxidative stress level in patients with periodontal disease and hyperlipidemia

Lütfioğlu, Müge; Aydoğdu, Ahmet; Atabay, Vadim Ekrem; Sakallıoğlu, Elif Eser; Avcı, Bahattin

doi:10.1590/1807-3107bor-2017.vol31.0110

Cited by 11 publications

(3 citation statements)

References 40 publications

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“…The TOC in GCF samples was determined using a commercially available human-speci c enzyme-linked immunosorbent assay (ELISA) in accordance with the manufacturer's instructions (TOC-ELISA kit) which are relatively accurate tests [41]. Assays of TOC have the advantage of analyzing the combined effectiveness of contributing species, which may be greater than the sum of the effects of the individual ROS.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Systemic Administration of Zinc on The Gingival Crevicular Fluid Level of Total Oxidant Capacity in Type 2 Diabetic Patients with Stage II and III Periodontitis After Non-Surgical Periodontal Therapy: A Randomized Clinical Trial

Alqawi

Mahmoud

Darhous

et al. 2022

Preprint

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Objectives: This study aimed to evaluate the effect of systemic administration of zinc supplementation on the total oxidant capacity in the gingival crevicular fluid level of controlled type 2 diabetic patients with stage-II and III periodontitis after non-surgical periodontal therapy.Materials and Methods: This clinical trial was registered at ClinicalTrials.gov Identifier: ID: NCT03923829 on April 23, 2019. Twenty-eight controlled type 2 diabetic patients with periodontitis stages II or III were randomly assigned into two groups, test and control where both received non-surgical periodontal therapy while the test group received 50 mg zinc one tablet/day for 12 weeks. Total oxidant capacity (TOC) level was measured in GCF of both groups at baseline and after 3 months. HbA1c level, GI, PPD and CAL were also reported at baseline and 3 months postoperatively.Results: After 3 months a statistically significant decrease in mean TOC µmol/L was reported in both groups being more significantly lower in test group. No significant difference in mean percentage HbA1c was reported after 3 months neither within each group nor between the two groups. In both groups there was a significant reduction in GI scores, PPD reduction and CAL gain after 3 months with no significant difference between them, while the test group showed significantly lower GI than the control group.Conclusions: Systemic administration of zinc supplements as an adjunct to non-surgical periodontal therapy might improve the clinical parameters and oxidative stress in T2DM patients with stage II-III periodontitis.Clinical Relevance:Zinc supplements can be an effective adjunct to nonsurgical periodontal therapy in type 2 diabetic patients with stages II or III periodontitis.

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Section: Discussionmentioning

confidence: 99%

The Effect of Systemic Administration of Zinc on The Gingival Crevicular Fluid Level of Total Oxidant Capacity in Type 2 Diabetic Patients with Stage II and III Periodontitis After Non-Surgical Periodontal Therapy: A Randomized Clinical Trial

Alqawi

Mahmoud

Darhous

et al. 2022

Preprint

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“…There are various reports suggesting a reduction in the TAOC in serum and gingival crevicular fluid in CP [5,6]. The results in various studies are not able to establish the correlation between salivary TAOC in health and CP.…”

Section: Introductionmentioning

confidence: 93%

Comparative Estimation of Salivary Total Antioxidant Capacity in Periodontal Health and Chronic Periodontitis - A Pilot Study

Raghavendra

Rao

D'suoza

et al. 2018

Asian J Pharm Clin Res

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Objective: Gram-negative bacteria provoke polymorphonuclear leukocyte (PMN) to release reactive oxygen species in chronic periodontitis (CP). Inability to maintain a balance between oxidative stress and antioxidant levels makes patients more susceptible to periodontal disease. The present study aims to estimate and compare salivary total antioxidant capacity (TAOC) in subjects with clinically healthy periodontium and patients with CP.Methods: After fulfilling the selection criteria, a total of 20 subjects (10 with clinically healthy periodontium and 10 with CP) were subjected to unstimulated salivary sample collection for biochemical estimation of TAOC by spectrophotometric assay using Kovacevic method. Analysis of data was done with unpaired student t-test, using SPSS version 22 statistical program.Results: Salivary TAOC was significantly higher in subjects with clinically healthy periodontium compared to CP patients. It was statistically significant (p<0.001).Conclusion: This study indicated increased levels of salivary TAOC in patients with CP compared to clinically healthy periodontium. Alteration in defensive antioxidant status could be a risk factor in the progression of periodontal disease.

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“…Over the past few years, numerous clinical and basic experimental studies have shown a strong association between oxidative stress and periodontitis, but most of these periodontal studies evaluated total antioxidant capacity, total oxidant status, and oxidative stress index [12]. However, other recent studies evaluated oxidative stress markers, such as MDA and 8-OHdG levels, but mainly at the local level in saliva [13][14][15][16] and gingival crevicular fluid [14,17] and only a few studies evaluated MDA and 8-OHdG levels in serum [13,18,19]. Although these studies have different results, associations between periodontitis and MDA and 8-OHdG levels have been observed [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Serum Inflammatory and Prooxidant Marker Levels in Different Periodontal Disease Stages

Andreu¹,

Santos-del-Riego²,

Payri³

2021

Healthcare

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Background: Periodontitis has been associated to systemic diseases and this association could be due to an increase in circulating inflammatory and oxidative stress biomarkers in the periodontal disease. This study aimed to evaluate the relationship between inflammatory and pro-oxidant markers according to different stages of periodontitis. Methods: This cross-sectional study included 70 subjects who were divided into three groups according to periodontitis stage: stage II (n = 22), stage III (n = 30), and stage IV (n = 18). We evaluated periodontal parameters and levels of high-sensitivity C-reactive protein (hsCRP), fibrinogen, and malondialdehyde (MDA) in serum, and 8-hydroxy-2′-deoxyguanosine (8-OHdG) in urine. Results: Serum hsCRP and fibrinogen levels were associated with periodontitis severity, which were higher in stage IV than in stages III and II of periodontitis (p = 0.003 and p = 0.025, respectively). We observed a slight yet insignificant increase in MDA levels related to periodontitis severity. Probing depth and clinical attachment loss were associated with serum fibrinogen and hsCRP levels. However, there were no significant associations between periodontal variables and MDA and 8-OHdG levels. Conclusion: Our data support an association between periodontitis and systemic inflammation, which increases with periodontal disease severity. This indicates the importance of the early diagnosis and treatment of periodontal disease to avoid the development or worsening of systemic inflammatory diseases.

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Gingival crevicular fluid oxidative stress level in patients with periodontal disease and hyperlipidemia

Cited by 11 publications

References 40 publications

The Effect of Systemic Administration of Zinc on The Gingival Crevicular Fluid Level of Total Oxidant Capacity in Type 2 Diabetic Patients with Stage II and III Periodontitis After Non-Surgical Periodontal Therapy: A Randomized Clinical Trial

The Effect of Systemic Administration of Zinc on The Gingival Crevicular Fluid Level of Total Oxidant Capacity in Type 2 Diabetic Patients with Stage II and III Periodontitis After Non-Surgical Periodontal Therapy: A Randomized Clinical Trial

Comparative Estimation of Salivary Total Antioxidant Capacity in Periodontal Health and Chronic Periodontitis - A Pilot Study

Serum Inflammatory and Prooxidant Marker Levels in Different Periodontal Disease Stages

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