Efficacy of two mouthwashes with cetylpyridinium chloride: a controlled randomized clinical trial

Abstract

This study aimed to evaluate the anti-plaque and anti-gingivitis effects of two mouthwashes containing cetylpyridinium chloride (CPC), in comparison to negative control mouthwash. One hundred and twenty subjects were randomly assigned to study groups: test (0.075% CPC and 0.28% zinc lactate), positive control (0.07% CPC) and negative control mouthwash without CPC. All volunteers were examined by a calibrated examiner for the Quigley-Hein Plaque Index (Turesky modification) and Löe-Silness Gingival Index (GI). Gingival severity was also measured by the percentage of sites with positive gingival bleeding. During six weeks, oral hygiene consisted of brushing twice daily with a toothbrush and toothpaste and rising with their assigned mouthwash. Plaque and gingival parameters were assessed at baseline, after four and six weeks of product use. Statistical analyses were performed separately for plaque and gingival indices, by ANOVA, paired t-test and ANCOVA (α < 0.05). After 4 and 6 weeks, all mouthwashes groups presented statistically significant reductions in plaque and gingival parameters as compared to baseline. In comparison to the positive control, the test group presented additional reductions in dental plaque of 19.8% and 16.8%, after 4 and 6 weeks, respectively. For GI, the additional reductions in the test group were 9.7% and 14.3%, at 4 and 6 weeks, respectively. The test group showed additional reduction of 35.3% and 54.5% in the gingival severity, at week 4 and 6, respectively. It is concluded that the mouthwash containing CPC and zinc lactate presents significant anti-plaque and anti-gingivitis effects as compared to positive and negative control mouthwashes.

Drugs used in the treatment of oral mucosal diseases

“…It is not preferred due to harmful effects according to the results of studies conducted in recent years. 21 Zinc salts are used due to their antibacterial properties.…”

“…Zinc ions have been found to reduce bacterial absorption and plaque build-up on teeth. 21 Antifungal mouthwashes: The most important advantage of antifungal mouthwashes and topical agents is that their side effects and systemic toxicities are little or none compared to systemic agents. There are only nystatin-containing preparations available in our country in suspension form among mouthwashes with an antifungal property.…”

“…After microbiological determination of Candida albicans, which causes oral candidiasis, it should be used in accordance with the doctor's recommendation. 21 Lidocaine HCl 1% cream, lidocaine 2% gel or spray, mouthwashes containing benzocaine pastilles, benzocaine, and cetylpyridinium chloride are other effective topical agents in reducing pain. 21,22 Tetracycline: Mouthwashes containing tetracycline reduce the size and duration of oral ulcers and pain.…”

“…21 Lidocaine HCl 1% cream, lidocaine 2% gel or spray, mouthwashes containing benzocaine pastilles, benzocaine, and cetylpyridinium chloride are other effective topical agents in reducing pain. 21,22 Tetracycline: Mouthwashes containing tetracycline reduce the size and duration of oral ulcers and pain. Tetracycline-containing mouthwashes have been demonstrated to be effective in prevention of secondary infections and concomitantly inhibit collagenase activity.…”

Eficácia de enxaguatórios bucais pré-procedimento na redução de microrganismos no aerossol: uma revisão sistemática

“…Apresenta eficácia contra microrganismos Gram-positivos, Gram-negativos e leveduras (Roberts;Addy, 1981;Rösing et al, 2017); A forma de ação desse agente é relacionada ao aumento da permeabilidade da parede celular da bactéria, favorecendo a sua lise, bem como a redução no metabolismo e a interrupção da capacidade do microrganismo para aderir à superfície do dente. Diferente da clorexidina apresenta baixas substantividade (Haps et al, 2008).…”