Comparisons of IgA response in saliva and colostrum against oral streptococci species

Bertoldo, Barbara Bellocchio; Silva, Camilla Beatriz da; Rodrigues, Denise Bertulucci Rocha; Geraldo-Martins, Vinícius Rangel; Ferriani, Virgínia Paes Leme; Nogueira, Ruchele Dias

doi:10.1590/1807-3107bor-2017.vol31.0039

Cited by 6 publications

(3 citation statements)

References 22 publications

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“…Salivary IgA reactivity to S. mutans antigens [ 11 , 12 ] suggests that responses to antigens, especially against major antigens in the S. mutans cell surface, such as glucan-binding protein B (GbpB), may affect the ability of S. mutans to colonize the oral cavity. This SIgA response to the GbpB antigen may modulate infection by S. mutans [ 80 ]. On the other hand, it should be mentioned that the interaction between members of oral microbiota mediates prokaryotic resistance to host innate immunity.…”

Section: Mechanisms Within the Oral Mucosa To Maintain The Microbial Balancementioning

confidence: 99%

Armed to the Teeth—The Oral Mucosa Immunity System and Microbiota

Ptasiewicz

Grywalska

Mertowska

et al. 2022

IJMS

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The oral cavity is inhabited by a wide spectrum of microbial species, and their colonization is mostly based on commensalism. These microbes are part of the normal oral flora, but there are also opportunistic species that can cause oral and systemic diseases. Although there is a strong exposure to various microorganisms, the oral mucosa reduces the colonization of microorganisms with high rotation and secretion of various types of cytokines and antimicrobial proteins such as defensins. In some circumstances, the imbalance between normal oral flora and pathogenic flora may lead to a change in the ratio of commensalism to parasitism. Healthy oral mucosa has many important functions. Thanks to its integrity, it is impermeable to most microorganisms and constitutes a mechanical barrier against their penetration into tissues. Our study aims to present the role and composition of the oral cavity microbiota as well as defense mechanisms within the oral mucosa which allow for maintaining a balance between such numerous species of microorganisms. We highlight the specific aspects of the oral mucosa protecting barrier and discuss up-to-date information on the immune cell system that ensures microbiota balance. This study presents the latest data on specific tissue stimuli in the regulation of the immune system with particular emphasis on the resistance of the gingival barrier. Despite advances in understanding the mechanisms regulating the balance on the microorganism/host axis, more research is still needed on how the combination of these diverse signals is involved in the regulation of immunity at the oral mucosa barrier.

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Section: Mechanisms Within the Oral Mucosa To Maintain The Microbial Balancementioning

confidence: 99%

Armed to the Teeth—The Oral Mucosa Immunity System and Microbiota

Ptasiewicz

Grywalska

Mertowska

et al. 2022

IJMS

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“…Previous studies about the immunological analysis of colostrum from Brazilian women showed high levels of immunoglobulin A against S. mutans and its virulence antigens, which could contribute to the modulation of S. mutans infection. ( 18 , 19 ) However, there is little information about the contribution of colostrum in the composition of oral colonization.…”

Section: Introductionmentioning

confidence: 99%

Streptococcus mutans detection in saliva and colostrum samples

Silva¹,

Mendes²,

Rodrigues³

et al. 2019

Einstein (São Paulo)

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Objective To detect Streptococcus mutans in colostrum and saliva of neonates and compare with its detection in saliva of mothers. Methods Forty-three healthy women, full-term gestations with no complications, submitted to elective Cesarean section, and their newborns were included in the study. Samples were investigated by polymerase chain reaction to detect S. mutans in genetic material from the samples. Results Approximately 16% of colostrum samples showed S. mutans , but not correlated with the presence of the bacteria in both samples of saliva. S. mutans was detected in 49 and 30% of saliva samples of mothers and neonates, respectively. There was a positive correlation in S. mutans detection between types of saliva. The number of maternal samples of saliva with detectable S. mutans was smaller in women receiving dental treatment during pregnancy. Tooth brushing, three times a day, influenced the detection of S. mutans in both the saliva and the colostrum. Conclusion Although maternal saliva may present S. mutans , few samples of colostrum present the bacteria. The presence of bacteria in neonate saliva may be related to contact before birth. Dental treatment and hygiene habits seem to influence the detection of S. mutans in samples of maternal saliva and colostrum.

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“…Immunization with different S. mutans antigens can induce high levels of IgG in the serum and IgA antibodies in the saliva, tears, colostrums and breast milk, promoting the reduction in counts and adherence of S. mutans, and the protection against dental caries [5][6][7][8]. The World Oral Health reported that the breast milk could prevent the occurrence of rampant caries in the early childhood [9]. Al Amoudi et al [10] observed that children with early childhood caries and their mothers had higher levels of sIgA when compared with caries free children and their mothers, showing a positive correlation between secretory IgA of mothers and children.…”

Section: Introductionmentioning

confidence: 99%

IgA antibodies against Streptococcus mutans in breast milk and saliva: Passive Immunity against caries

Mitterhofer

Sherma

Santos

et al. 2019

BDS

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Objective: The present work aimed to correlate the levels of IgA antibodies reactive with Streptococcus mutans antigens in the saliva and/or in the breast milk and the oral health of lactating. Material and methods: Breast milk and whole saliva samples were collected from 29 lactating. The oral health was verified using DMF scores and the volunteers were separated in three groups: 1) low DMF score; 2) high DMF score with active caries and 3) high DMF score without active caries. The IgA antibodies anti-Streptococcus mutans were analyzed in the samples using ELISA technique. Results: The results showed similar levels of IgA antibodies in all groups, both in milk and saliva. No correlation could be confirmed between the levels of IgA in the saliva and in the breast milk with the oral health of lactating studied. Conclusion: The results suggest that, independently of mother’s oral health, the newborn receive the same amounts of anti-Streptococcus mutans IgA by breastfeeding.

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Comparisons of IgA response in saliva and colostrum against oral streptococci species

Cited by 6 publications

References 22 publications

Armed to the Teeth—The Oral Mucosa Immunity System and Microbiota

Armed to the Teeth—The Oral Mucosa Immunity System and Microbiota

Streptococcus mutans detection in saliva and colostrum samples

IgA antibodies against Streptococcus mutans in breast milk and saliva: Passive Immunity against caries

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