Zika virus infection spread through saliva – a truth or myth?

Siqueira, Walter L.; Moffa, Eduardo Buozi; Mussi, Maria Carolina Martins; Machado, Maria Aparecida de Andrade Moreira

doi:10.1590/1807-3107bor-2016.vol30.0046

Cited by 24 publications

(23 citation statements)

References 16 publications

(17 reference statements)

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“…According to a previous study on vesicular stomatitis virus, this pathogen has a strong aggregating ability in the presence of saliva, and some host factors, such as fibrinogen, could promote this saliva-induced aggregation process, suggesting the important role saliva plays in the biological behavior of this virus (Anschau & Sanjuan, 2020). According to another study, the biochemical components of saliva are closely associated with the presence of Zika virus (ZIKV), indicating complex interactions between the virus and saliva (Siqueira, Moffa, Mussi, & Machado, 2016). Hence investigation of the biological functions of saliva on the behavior of viruses, and the impact of virus on the composition of saliva, suggest the transmission of virus can be closely connected with saliva.…”

Section: Saliva a S A P Otential Source Of Virus S Pre Admentioning

confidence: 99%

Saliva is a non‐negligible factor in the spread of COVID‐19

Ren

Peng

et al. 2020

Molecular Oral Microbiology

171

148

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SARS‐CoV‐2, a novel emerging coronavirus, has caused severe disease (COVID‐19), and rapidly spread worldwide since the beginning of 2020. SARS‐CoV‐2 mainly spreads by coughing, sneezing, droplet inhalation, and contact. SARS‐CoV‐2 has been detected in saliva samples, making saliva a potential transmission route for COVID‐19. The participants in dental practice confront a particular risk of SARS‐CoV‐2 infection due to close contact with the patients and potential exposure to saliva‐contaminated droplets and aerosols generated during dental procedures. In addition, saliva‐contaminated surfaces could lead to potential cross‐infection. Hence, the control of saliva‐related transmission in the dental clinic is critical, particularly in the epidemic period of COVID‐19. Based on our experience of the COVID‐19 epidemic, some protective measures that can help reduce the risk of saliva‐related transmission are suggested, in order to avoid the potential spread of SARS‐CoV‐2 among patients, visitors, and dental practitioners.

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Section: Saliva a S A P Otential Source Of Virus S Pre Admentioning

confidence: 99%

Saliva is a non‐negligible factor in the spread of COVID‐19

Ren

Peng

et al. 2020

Molecular Oral Microbiology

171

148

View full text Add to dashboard Cite

show abstract

“…Recent findings have shown that ZIKV can be detected in the saliva of infected mothers and their neonates, but until now, there has been no evidence that ZIKV can be transmitted through human saliva (Siqueira, Moffa, Mussi, & Machado, ). A recent outbreak of ZIKV occurred in Latin America.…”

Section: Anti‐viral Effects Of Lf and Lf‐derived Peptidesmentioning

confidence: 99%

Role of lactoferrin and lactoferrin‐derived peptides in oral and maxillofacial diseases

et al. 2018

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The oral cavity harbors different taxonomic groups, the evolutionary coexistence of which develops the oral ecosystem. These resident microorganisms can alter the balance between the physiologic and pathologic conditions that affect the host, both locally and systemically. This highly sophisticated nature of the oral cavity poses a significant therapeutic challenge. Numerous human and animal studies have been conducted to potentiate the efficacy and competence of current treatments of pathologic conditions as well as to develop novel therapeutic modalities. One of these studies is the use of the potent antimicrobial agent lactoferrin (LF), which was originally derived from the host immune system. LF is an 80-kDa glycoprotein that has a free iron sequestration mechanism with evident antimicrobial, anti-tumor, and immunomodulatory properties. A wide range of active peptides have been isolated from the N-terminal region of LF, which possess antimicrobial activities. In this review, we discuss the role of LF and LF-derived peptides under a heterogeneous group of oral and maxillofacial conditions, including bacterial, fungal, viral infections; head and neck cancers; xerostomia; and implantology-bone-related manifestations.

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“…Mutations in COL1A1/2 genes were associated with congenital brittle bones with the development of microcephaly and cataracts, as observed in the most severe cases of CSZ 40 . A dominant mutation in COL12A1 was also related to joint laxity 41 , a phenotype often found in ZIKV-infected children 42 .…”

Section: Discussionmentioning

confidence: 90%

The potential role of collagens in congenital Zika syndrome: A systems biology approach

Aguiar

Pohl

Morais³

et al. 2019

Preprint

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Zika virus (ZIKV) infection during pregnancy could cause a set of severe abnormalities in the fetus known as congenital Zika syndrome (CZS).Experiments using animal models and in vitro systems significantly contributed to our understanding of the physiopathology of ZIKV infection. However, the molecular basis of CZS is not yet studied in humans. Here, we used a systems biology approach to integrate transcriptomic, proteomic and genomic data from post-mortem brains of neonates with CZS. We observed that collagen genes were greatly reduced in CZS brains at both the RNA and protein levels and that neonates with CZS have several polymorphisms in collagen genes associated with osteogenesis imperfect and arthrogryposis. These findings were validated using immunohistochemistry and collagen staining of ZIKV infected and noninfected samples. Additionally, it was found that cell adhesion genes that are essential for neurite outgrowth and axon guidance were up-regulated and thereby confirmed the neuronal migration defects observed. This work provided new insights into the underlying mechanisms of CZS and revealed host genes associated with CZS susceptibility.

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Zika virus infection spread through saliva – a truth or myth?

Cited by 24 publications

References 16 publications

Saliva is a non‐negligible factor in the spread of COVID‐19

Saliva is a non‐negligible factor in the spread of COVID‐19

Role of lactoferrin and lactoferrin‐derived peptides in oral and maxillofacial diseases

The potential role of collagens in congenital Zika syndrome: A systems biology approach

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