Association of Interleukin-17 polymorphism (-197G/A) in chronic and localized aggressive periodontitis

Abstract

Interleukin 17(IL-17) is a pro-inflammatory cytokine produced mainly by Th17 cells. The present study was undertaken to investigate a possible association between IL-17 A genetic polymorphism at (-197A/G) and susceptibility to chronic and localized aggressive periodontitis (LAgP) in an Indian population. The study was carried out on 105 subjects, which included 35 LAgP patients, 35 chronic periodontitis patients and 35 healthy controls. Blood samples were drawn from the subjects and analyzed for IL-17 genetic polymorphism at (-197A/G), by using the polymerase chain reaction-restriction fragment length polymorphism method. A statistically significant difference was seen in the genotype distribution among chronic periodontitis patients, LAgP patients and healthy subjects. There was a significant difference in the distribution of alleles among chronic periodontitis patients, LAgP patients and healthy subjects. The odds ratio for A allele versus G allele was 5.1 between chronic periodontitis patients and healthy controls, and 5.1 between LAgp patients and healthy controls. Our study concluded that IL-17 A gene polymorphism at (-197A/G) is linked to chronic periodontitis and LAgP in Indian population. The presence of allele A in the IL-17 gene polymorphism (-197A/G) can be considered a risk factor for chronic periodontitis and LAgP.

Association of A‐197G polymorphism in interleukin‐17 gene with chronic periodontitis: Evidence from six case‐control studies with a computational biology approach

“…After reviewing the abstracts of the 33 articles, the irrelevant studies were excluded. Finally, five eligible studies were included in the meta‐analysis . Our case‐control results were added to the pooled data.…”

“…With regard to inconsistent results from previous studies, we performed a meta‐analysis to obtain a more accurate conclusion. To the best of our knowledge, there are five studies that have investigated the association of SNP with CP, and the present study is the first meta‐analysis on this topic. Our data from this meta‐analysis revealed that there are significant associations between the IL‐17 A‐197G polymorphism and risk of CP in the overall analysis.…”

“…Furthermore, there is a single nucleotide polymorphism (SNP) in the promoter region of IL‐17 (A‐197G, rs2275913) that is associated with the overexpression of IL‐17 in patients with chronic periodontitis (CP) . There have been studies investigating the association of the IL‐17 A‐197G polymorphism with CP, but the results are inconclusive . The aim of the present study was to investigate the association of the IL‐17 A‐197G gene transition with CP risk in a case‐control experiment, which was followed by a meta‐analysis approach and an in silico analysis.…”

“…9 There have been studies investigating the association of the IL-17 A-197G polymorphism with CP, but the results are inconclusive. [9][10][11] The aim of the present study was to investigate the association of the IL-17 A-197G gene transition with CP risk in a case-control experiment, which was followed by a metaanalysis approach and an in silico analysis.…”

Osteoprotegerin Gene (OPG) Polymorphisms Associated with Peri-implantitis Susceptibility in a Chinese Han Population

“…There are similarities in aspects of microbiology and clinical and pathological manifestations between peri-implantitis and periodontitis, but there are still differences in the rate and extent of inflammation, as well as in cell composition [2,3]. Studies have shown chronic periodontitis was significantly associated with cytokine gene polymorphisms and environmental factors [4,5]; therefore, when studying the cause of peri-implantitis, the role of molecular genetic susceptibility and environmental factors should be considered.…”