A 10-year analysis of the oral squamous cell carcinoma profile in patients from public health centers in Uruguay

Oliveira, Maria Laura Cosetti; Wagner, Vivian Petersen; Filho, Manoel Sant’Ana; Carrard, Vinícius Coelho; Hugo, Fernando Neves

doi:10.1590/1807-3107bor-2015.vol29.0075

Cited by 39 publications

(50 citation statements)

References 20 publications

(49 reference statements)

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“…In a study conducted by Oliveira et al, there were 85.3% subjects who had habit of chewing or smoking tobacco. 22 In their study, alcohol consumption was seen in 63.5% cases. In our study, There were 18.3% (n=11) subjects having cancer of tongue.…”

Section: Discussionmentioning

confidence: 86%

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Clinical findings and risk factors associated with oral cancer: a prospective study

Gupta¹,

Singh²,

Bedi³

et al. 2018

Int J Otorhinolaryngol Head Neck Surg

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Background: Oral cancer is associated with high morbidity and mortality and therefore it represents a grave health problem worldwide. However there is scarcity of the studies in the literature regarding the prognostic factors amongst the subjects. The aim of the present study is to determine the various risk factors and the most commonly affected sites by the oral squamous cell carcinoma amongst subjects of different age groups. Methods: The present prospective comparative study was conducted at the Department of Radiotherapy at Guru Gobind Singh Medical College and Hospital during a period of three months i.e. from April 2016 to June 2016. Patients were evaluated every week for a period of approximately 2 weeks. Examination of the oral cavity was done using probe and mouth mirror by trained personnel. TNM classification was used to classify tumour. Patient’s habits like alcohol and tobacco intake were also recorded. Complete demographic information was obtained from all the patients. All the data thus obtained was arranged in a tabulated form and analysed using SPSS software. Results: The study included a total of 60 subjects. There were 11 females in the study and 49 males in the study. There were 18.3% (n=11) subjects having cancer of tongue. There were 23.3% (n=14) subjects having cancer of buccal mucosa. Alveolar ridge carcinoma was seen in 8.3% (n=5) subjects. There were 22 patients (30%) having stage III carcinoma. Majority of the subjects i.e. 70% (n= 38) were at stage IV A according to TNM classification. Conclusions: From the above study we can conclude that there is lack of awareness amongst the people about oral cancer. They mostly present during advanced stage of the disease. Most of the subjects are males, showing there predisposition towards harmful habits.

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Section: Discussionmentioning

confidence: 86%

“…In a study conducted by Oliveira et al, the most commonly affected site was tongue (42.5%). 22 In another study conducted by Hellen-Bandeira et al tongue was the most commonly affected site followed by lower lip.…”

Section: Discussionmentioning

confidence: 90%

Clinical findings and risk factors associated with oral cancer: a prospective study

Gupta¹,

Singh²,

Bedi³

et al. 2018

Int J Otorhinolaryngol Head Neck Surg

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“…[5][6][7] Age-adjusted rates of oral cancer in India are high, i.e, 20 per 100,000 population and account for over 30% of all cancers in the country. 1,8 Tobacco use, and in particular smoking, is the largest cause of preventable death among adults in India, as it is globally.…”

Section: Discussionmentioning

confidence: 99%

Risk factors in oral carcinoma and the relationship between tumor thickness and regional nodal involvement: a pilot study in a semi urban population in New Delhi, India

2017

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Background: Oral squamous cell carcinoma (OSCC) is a major public health problem worldwide, with approximately 275,000 cases annually and a strong association with risk factors like smoking. It is a subtype of head & neck cancer involving the oral cavity. The present study evaluated the role of various risk factors in the development of oral carcinoma among our patient population.Methods: A total of 40 cases of oral carcinoma with radical neck dissection were evaluated. Data on the age, personal history and presenting clinical features were analyzed. The depth of the tumor and the maximum tumor thickness were carefully evaluated. Also, pathological T-stage, the presence/absence of vascular and peri-neural infiltration was evaluated in each case. The presence of nodal metastases and the stage of the tumor was assessed. Data was tabulated and correlation of nodal metastasis with tumor thickness, pathological T-stage, vascular invasion, and peri-neural infiltration was evaluated by appropriate statistical analysis method.Results: A total of 40 cases, 82.5% males and 17.5% females, were all smokers with history of consumption of smoking or smokeless or both. Tongue was the most common site of oral carcinoma (37.5%) involvement, histological characterization of all were Squamous cell carcinoma with majority of the patients in pathological stage II. A significant association between the tumor thickness and metastasis was also seen. Conclusions: The tumor thickness of oral squamous cell carcinoma was found to be an important prognostic indicator for the occurrence of metastases to the regional cervical lymph nodes.

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“…Studies have shown different patterns of oral squamous cells carcinomas in the various regions of the world, but few studies have evaluated this neoplasm in the Uruguayan population 2,9 . In addition, in Uruguay oral squamous cell carcinoma (OSCC) is diagnosed late, which provides poor prognosis and low survival rate for this disease 20 .…”

Section: Introductionmentioning

confidence: 99%

Cell proliferation markers at the invasive tumor front of oral squamous cell carcinoma: comparative analysis in relation to clinicopathological parameters of patients

et al. 2017

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Objectives To evaluate the number of AgNORs per nucleus and the expression of Ki-67 at the tumor invasion front (TIF) in relation to clinical parameters (TNM), TIF classification and the prognosis of oral squamous cell carcinomas in an Uruguayan population.Material and Methods This study was conducted through a retrospective survey from 2000 to 2010 at the National Institute of Cancer Montevideo, Uruguay and included 40 patients. The samples were obtained from the resection of the tumor and the TIF was defined according with Bryne, et al.5 (1992). Expression of Ki-67 was assessed by the percentage of positive tumor cells and the AgNOR was recorded as the mean AgNOR (mAgNOR) and the percentage of AgNOR per nucleus (pAgNOR). All analyzes were performed by a blinded and calibrated observer.Results No statistically significant association was observed between immunostaining of Ki-67 and AgNOR with the different types of TIF, regional metastasis and patients prognosis, however it was observed an increase in Ki-67 expression associated with worse patient’s clinical staging, although not statistically significant.Conclusions Our results suggest that proliferation markers as AgNOR and Ki-67 are not prognostic markers at the tumor invasive front of carcinoma of oral squamous cell.

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A 10-year analysis of the oral squamous cell carcinoma profile in patients from public health centers in Uruguay

Cited by 39 publications

References 20 publications

Clinical findings and risk factors associated with oral cancer: a prospective study

Clinical findings and risk factors associated with oral cancer: a prospective study

Risk factors in oral carcinoma and the relationship between tumor thickness and regional nodal involvement: a pilot study in a semi urban population in New Delhi, India

Cell proliferation markers at the invasive tumor front of oral squamous cell carcinoma: comparative analysis in relation to clinicopathological parameters of patients

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