Cariogenic and erosive potential of pediatric medicines and vitamin supplements

Coutinho, Luciene Souza; SANDE, Ana Caroline Magalhães Neri; Nunes, Natália Novais Vasconcelos; Oliveira, Rafaela Silva; Campos, Elisângela de Jesus

doi:10.1590/1807-2577.00622

Cited by 2 publications

(2 citation statements)

References 12 publications

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“…We found that 98.37% (61) of the evaluated ODTs presented with sugar similar to previous studies on LOM. 35 , 42 But few studies on LOMs, showed the presence of sugar in 40-70% of the formulations. 13 , 43 , 44 Out of the 62 ODTs, only one medication in the anticonvulsant category (Lamitor DT) was sugar-free.…”

Section: Discussionmentioning

confidence: 99%

Sugar content and erosive potential of commonly prescribed Orodispersible tablets- An in vitro study.

et al. 2023

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Background: Dental caries is a major non-communicable disease of public health concern caused due to freely available dietary sugars. We aimed to compare the sugar content and erosive potential with duration of use and drug classes of orodispersible tablets (ODTs). Methods: We conducted an in vitro evaluation of the total sugar content (TSC), Potential of Hydrogen (pH), solubility, and Titratable Acidity (TA) of commonly prescribed 62 ODTs. TA was measured by titrating the samples with known amount of. 0.1N sodium hydroxide (NaOH) with phenolphthalein indicator and pH was determined by digital pH meter. TSC was evaluated by phenol sulphuric acid. Solubility was assessed by filtration. Results: Out of the 62 ODTs, majority were Antimicrobials (n=30). One-quarter of the ODTs (26%) had a mean pH below ≤5.5. No significant difference was seen in the mean pH with respect to different drug classes (p=0.082) and duration of use of ODTs. A significant difference was seen in the mean percentage solubility with respect to drug classes (p<0.001). Antimicrobials had the least percentage of solubility as compared to other drug classes. Antiemetics and proton pump inhibitors (24.33 ± 17.34) had significantly higher mean percentage sugar content than Antimicrobials (23.25 ± 17.16). No significant difference was seen in the mean TSC with respect to various drug classes (p=0.718) and between the duration of use of drugs (P=0.568) respectively. No significant difference was seen in the mean percentage TA with respect to drug class (p=0.123) and duration of use of drugs (p=0.424). Conclusion: Overall, we can conclude that one in four ODT formulations had a pH below 5.5 (critical pH). Only one ODT formulation did not have a sugar content. No difference was seen in the mean pH, sugar content, and TA with respect to duration of use of drugs and drug classes.

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Section: Discussionmentioning

confidence: 99%

Sugar content and erosive potential of commonly prescribed Orodispersible tablets- An in vitro study.

et al. 2023

View full text Add to dashboard Cite

show abstract

“…We found that 98.37% (61) of the evaluated ODTs presented with sugar similar to previous studies on LOM. 35,42 But few studies on LOMs, showed the presence of sugar in 40-70% of the formulations. 13,43,44 Out of the 62 ODTs, only one medication in the anticonvulsant category (Lamitor DT) was sugar-free.…”

Section: Discussionmentioning

confidence: 99%