Is the COVID-19 disease associated with de novo nephritic syndrome?

Abstract

SUMMARY INTRODUCTION: This study aims to determine the incidence of de novo nephritic syndrome (NS) in COVID-19 patients and identify its associated factors. METHODS: All ward patients with COVID-19 pneumonia were investigated. After determining the inclusion and exclusion criteria, the study population was identified. The urine dipstick test and urine protein creatinine ratio (UPCR) measurements were performed. Patients with de novo NS findings, nasopharyngeal swab, and urine RT-PCR tests were performed simultaneously RESULTS: This descriptive cross-sectional study was conducted with 21 patients with COVID-19. The mean age of the patients was 42.2±8.8 years, and 71.4% of them were male. The mean duration of follow-up was 28.4±9.3 days. The urine RT-PCR test was positive in one patient (4.8%). Improvements were observed in hematuria by 71.4%, and proteinuria by 85.7% at the end of the follow-up. A significant decrease in the measured UPCR was found in comparison to the baseline(P=0.000). Also, improvements were recorded in the complete blood counts, inflammatory parameters, ferritin, and coagulation tests, compared to the baseline. There was a positive correlation between baseline UPCR and ferritin, and a negative correlation between baseline UPCR and sodium values CONCLUSION: COVID-19-induced de novo nephritic syndrome may occur mainly due to tubulointerstitial involvement and often results in spontaneous remission. However, why these findings were not present in all patients who had no comorbidities is not clear.

Persistence of SARS-CoV-2 RNA in Nasopharynx, Blood, Urine and Stool of Patients with COVID 19: A Hospital-based Longitudinal Study

“…Our ndings revealed that the positive urine SARS-CoV-2 RNA RT-PCR was less common (7 out of 100 patients) in our study population and all of them turned to negative at the time of discharge. Our result was in accordance with studies in Turkey and China that demonstrated nearly 5-7% of COVID-19 patient had positive urine RT-PCR [23,24].…”

Persistence of SARS-CoV-2 RNA in the nasopharyngeal, blood, urine, and stool samples of patients with COVID-19: a hospital-based longitudinal study

“…The present findings revealed that positive results of urine SARS-CoV-2 RNA RT-PCR were less common (found in 7/100 patients) in our study population, all of which became negative at the time of discharge. This result is consistent with previous studies from Turkey and China, which demonstrated that nearly 5-7% of COVID-19 patients had positive urine RT-PCR results [24,25].…”

365 Dias de pandemia de COVID-19 e a realidade brasileira: pesquisas e reflexões

“…O contexto pandêmico global provocado pelo vírus SARS-Cov-2 (COVID-19) teve início em dezembro de 2019 na China, na cidade de Wuhan, província de Hubei e, em março de 2020, foi oficializado pela World Health Organization (WHO) (DUARTE et al,2020;DHEIR et al,2020). A doença causada pelo COVID-19, inicialmente provoca uma síndrome respiratória de sintomatologia leve na maioria dos pacientes que evolui para um quadro gripal, entretanto uma parcela desses pacientes tem seu quadro agravado (DHEIR et al,2020).…”

“…O contexto pandêmico global provocado pelo vírus SARS-Cov-2 (COVID-19) teve início em dezembro de 2019 na China, na cidade de Wuhan, província de Hubei e, em março de 2020, foi oficializado pela World Health Organization (WHO) (DUARTE et al,2020;DHEIR et al,2020). A doença causada pelo COVID-19, inicialmente provoca uma síndrome respiratória de sintomatologia leve na maioria dos pacientes que evolui para um quadro gripal, entretanto uma parcela desses pacientes tem seu quadro agravado (DHEIR et al,2020). O comprometimento respiratório, imune e hematopoiético leva à progressão da doença para um quadro de Síndrome do Desconforto Respiratório Agudo (SDRA) associada ao risco de lesões extrapulmonares, principalmente renal, colocando tais pacientes circunscritos a uma alta taxa de mortalidade (DHEIR et al,2020;DUARTE et al, 2020).…”

“…Embora a fisiopatologia e os mecanismos de ação do vírus ainda não sejam completamente conhecidos, estudos comprovam dano renal provocado pelo vírus COVID-19, principalmente lesões tubulointersticiais (lesões do túbulo proximal e endotelial), comprometendo a filtração glomerular agravado em pacientes com intubação prolongada. (DHEIR et al,2020;COUTURIER et al, 2020;DUARTE et al, 2020;MACEO-SOBRADO et al, 2020). Antecedentes de saúde como diabetes mellitus, Insuficiência Renal Crônica (IRC), hipertensão arterial sistêmica e outras comorbidades também estão envolvidos no comprometimento renal em pacientes com COVID-19 e sua alta mortalidade (LÉON-VIDAL et al, 2020;LI et al, 2020;MACEO-SOBRADO et al, 2020).…”