Association between vitamin D and cardioprotection in adult patients

Abstract

OBJECTIVE: To conduct a review of articles which have evaluated the relationship between vitamin D and cardioprotection in adult. METHODS: A literature search was performed in the Pubmed and Scielo databases. The results were extracted from primary and secondary sources and will be presented in the form of a bibliographic review. RESULTS: Twenty-three articles were identified from the electronic search that reported on physiological mechanisms relating the vitamin D axis and the cardiovascular system through receptors. Of the ten studies that evaluated the therapeutic effect of vitamin D in cardiovascular diseases, none reported significant results. CONCLUSION: The articles assessed in this review did not demonstrate a cardioprotective effect of vitamin D, despite the epidemiological correlation of vitamin D deficiency with a higher prevalence of cardiovascular diseases.

Deficiency and Insufficiency of Vitamin D in Women of Childbearing Age: A Systematic Review and Meta-analysis

“…It is important to highlight that our systematic review identified several studies evaluating nonpregnant and nonlactating women, which were grouped as women of childbearing age. Notwithstanding, it was noted that many of these women had conditions associated with inadequate levels of vitamin D, such as overweight or obesity, [77][78][79] gestational diabetes mellitus, 80 preeclampsia, 81,82 cardiovascular disease, 83 breast cancer, 84 polycystic ovarian syndrome, 85 and infertility, 86 among others, which may overestimate the identified prevalence.…”