Assessment of the hemogram parameters in patients with paroxysmal supraventricular tachycardia: a retrospective study

Cosgun, Mehmet; Güneş, Yılmaz; Sıncer, İsa; Mansıroğlu, Aslı Kurtar

doi:10.1590/1806-9282.66.10.1371

Cited by 2 publications

(3 citation statements)

References 20 publications

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“…Sinus tachycardia in patients who seek emergency care, and the presence of anxiety disorder can lead to diagnostic errors. It is common to find patients with AVNRT who were treated with anxiolytics for decades [6][7][8][9][10][11][12] .…”

Section: Resultsmentioning

confidence: 99%

“…For this, 196 patients who underwent electrophysiological study due to palpitation or paroxysmal supraventricular tachycardia (PSVT), including AVNRT, underwent the following laboratory tests: monocyte count to high-density lipoprotein cholesterol ratio (MHR), neutrophil/lymphocyte ratio (NLR), and monocyte/lymphocyte ratio (MLR). However, it was found that patients with PSVT did not show any significant difference in these inflammatory markers 10 . Hence, it is not possible to diagnose AVNRT through laboratory tests.…”

Section: Laboratory Testsmentioning

confidence: 95%

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Desafios no diagnóstico da taquicardia por reentrada nodal: revisão bibliográfica

Carmo¹,

Sobral²

2021

Rev. Med. (São Paulo)

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A taquicardia por reentrada nodal (TRN) é caracterizada pela reentrada do impulso elétrico na área do nó atrioventricular (NAV). Geralmente, apresenta-se de forma benigna, sendo duas vezes mais frequente em mulheres do que em homens. O diagnóstico se baseia na apresentação clínica do paciente e no ECG de 12 derivações e caracteriza-se por pseudo r’ na derivação V1 ou deflexão pseudo S’ nas derivações inferiores. Possíveis dificuldades no diagnóstico podem ser relacionadas com o tempo decorrido de deslocamento do paciente até o hospital, a curta duração das crises e intervalo entre elas e a ausência de doenças cardiovasculares prévias. Esta revisão objetiva analisar as estratégias diagnósticas da TRN, tendo como base produções científicas publicadas nas seguintes bases de dados: National Library of Medicine (PubMed), Scientific Eletronic Library On-line (SciELO) e US National Library of Medicine (NCBI). Devido à inespecífica gama de sintomas e à ocorrência de crises espaçadas e de curta duração, a TRN pode ser erroneamente diagnosticada como quadro ansioso. Observou-se que o Holter de 24 horas é o exame mais utilizado na prática clínica, porém um dos menos eficazes. Apesar do custo elevados e do acesso restrito, exames diagnósticos como o looper externo, o EEF e, até mesmo, o Holter de 48 horas apresentam taxas de detecção significativamente maiores, tornando o diagnóstico da TRN facilitado.

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Section: Resultsmentioning

confidence: 99%

Section: Laboratory Testsmentioning

confidence: 95%

Desafios no diagnóstico da taquicardia por reentrada nodal: revisão bibliográfica

Carmo¹,

Sobral²

2021

Rev. Med. (São Paulo)

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“…Atrial fibrillation itself might promote systemic inflammation during atrial remodeling and induce a spurious inverse association. In addition, observational studies have come to conflicting conclusions about the association of leukocyte counts with supraventricular tachycardia ( 17 , 18 ). Therefore, evidence from observational studies alone is insufficient.…”

Section: Introductionmentioning

confidence: 99%

Association between circulating leukocytes and arrhythmias: Mendelian randomization analysis in immuno-cardiac electrophysiology

et al. 2023

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BackgroundCardiac arrhythmia is a common disease associated with high mortality and morbidity. Circulating leukocyte counts, which serve as a biomarker for assessing systemic immune status, have been linked to arrhythmias in observational studies. However, observational studies are plagued by confounding factors and reverse causality, whether alterations in circulating leukocyte components are causally associated with arrhythmias remains uncertain. The present study explored this question based on genetic evidence.Methods and findingsWe performed Mendelian randomization (MR) analysis to evaluate whether alterations in leukocyte counts affect aggregated risk of all types of arrhythmia or risk of five specific types of arrhythmia. Single-nucleotide polymorphisms serving as proxies for leukocyte differential counts were retrieved from the Blood Cell Consortium, and statistical data on arrhythmias were obtained from the UK Biobank), FinnGenand a meta-analysis of genome-wide association studies for atrial fibrillation. We applied inverse variance-weighted method as the primary analysis, complemented by a series of sensitivity analyses. Bidirectional analyses were conducted to assess reverse causality. Finally, multivariable MR was performed to study the joint effects of multiple risk factors. We found that genetically predicted differential leukocyte counts were not significantly associated with aggregated occurrence of all types of arrhythmia. In contrast, each 1-standard deviation increase in lymphocyte count was associated with 46% higher risk of atrioventricular block (OR 1.46, 95% CI 1.11–1.93, p=0.0065). A similar effect size was observed across all MR sensitivity analyses, with no evidence of horizontal pleiotropy. Reverse MR analysis suggested that atrioventricular block was unlikely to cause changes in lymphocyte count. Primary MR analysis based on the inverse-variance weighted method suggested that changes in neutrophil count alter risk of right bundle branch block, and changes in basophil count alter risk of atrial fibrillation. However, these causal relationships were not robust in sensitivity analyses. We found no compelling evidence that neutrophil or lymphocyte counts cause atrial fibrillation.ConclusionOur data support higher lymphocyte count as a causal risk factor for atrioventricular block. These results highlight the importance of immune cells in the pathogenesis of specific cardiac conduction disorders.

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Assessment of the hemogram parameters in patients with paroxysmal supraventricular tachycardia: a retrospective study

Cited by 2 publications

References 20 publications

Desafios no diagnóstico da taquicardia por reentrada nodal: revisão bibliográfica

Desafios no diagnóstico da taquicardia por reentrada nodal: revisão bibliográfica

Association between circulating leukocytes and arrhythmias: Mendelian randomization analysis in immuno-cardiac electrophysiology

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