2020
DOI: 10.1590/1806-9282.66.1.12
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: SUMMARY Drug-induced liver injury (DILI) to flucloxacillin is rare and is classified as idiosyncratic, as it is dependent on individual susceptibility, unpredictable, and dose-independent. The authors present the case of a 74 - year - old man with a history of monoclonal gammopathy under investigation and alcoholic habits of 24 g/day, with asthenia, anorexia, nausea, abdominal discomfort, and fever with three days of evolution. He was treated with two courses of antibiotic therapy with flucloxacillin to erysip… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
5
0

Year Published

2020
2020
2023
2023

Publication Types

Select...
6
1
1

Relationship

0
8

Authors

Journals

citations
Cited by 16 publications
(5 citation statements)
references
References 8 publications
(2 reference statements)
0
5
0
Order By: Relevance
“… 41 , 53–56 Genome-wide association studies have shown genetic susceptibility for flucloxacillin-related DILI in individuals with a major histocompatibility complex region genotype HLA-B*57:01. 9 , 10 Also, some reports suggest a chemically mediated reaction to toxic metabolites from high doses of nafcillin and oxacillin; this has been reported for doses exceeding 12 g/day of oxacillin. 42 , 56–58 However, other studies failed to replicate this dose–response relationship.…”
Section: Discussionmentioning
confidence: 99%
“… 41 , 53–56 Genome-wide association studies have shown genetic susceptibility for flucloxacillin-related DILI in individuals with a major histocompatibility complex region genotype HLA-B*57:01. 9 , 10 Also, some reports suggest a chemically mediated reaction to toxic metabolites from high doses of nafcillin and oxacillin; this has been reported for doses exceeding 12 g/day of oxacillin. 42 , 56–58 However, other studies failed to replicate this dose–response relationship.…”
Section: Discussionmentioning
confidence: 99%
“…16 For example, HLA-B*14:01 is associated with trimethoprim-sulfamethoxazole-induced liver injury in European Americans, and HLA-B*5701 is associated with flucloxacillininduced DILI. 17,18 We hypothesize that genetic polymorphisms could be associated with MTX-induced DILI, and therefore we performed a genomewide association study (GWAS) in a case-control design to explore genetic risk factors associated with MTXDILI in patients with RA.…”
Section: How Might This Change Clinical Pharma-cology or Translationa...mentioning
confidence: 99%
“…Interestingly, genetic variants in the human leukocyte antigen ( HLA ) gene have been related to DILI for a variety of drugs, albeit not with MTX‐induced DILI 16 . For example, HLA‐B*14:01 is associated with trimethoprim‐sulfamethoxazole‐induced liver injury in European Americans, and HLA‐B*5701 is associated with flucloxacillin‐induced DILI 17,18 …”
mentioning
confidence: 99%
“…These observations support the suspected idiosyncratic nature of this toxicity. Genetic factors appear to potentiate the risk of beta-lactam DILI ( 86 , 87 ).…”
Section: Finding the Ceiling: Defining The Threshold For Beta-lactam Toxicitymentioning
confidence: 99%