Comparison of different types of endovascular mechanical embolectomy in acute ischemic stroke

Yuan, Ping

doi:10.1590/1806-9282.65.3.342

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…The principle of treatment is to restore the blood flow of the ischemic tissue as soon as possible, deliver nutrients such as sugar and oxygen, and reduce ischemia-reperfusion injury and cell apoptosis. 2 Leptin is a polypeptide hormone encoded by an obesity (OB) gene with a molecular weight of 16 kDa. Leptin is mainly synthesized and released by fat cells.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective effect of leptin on a primate model of cerebral ischemia

Cheng

Deng

Zhou

et al. 2021

Animal Biotechnology

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The purpose of this study was to evaluate the neuroprotective effect of leptin on a nonhuman primate model of cerebral ischemia. A total of 39 Guangxi macaques were used to establish the primate cerebral-ischemia model. HE staining was used to evaluated the pathological changes. Moreover, magnetic resonance imaging was used for the detection of embolic area. The measurements of behavior observation and cerebral infarction area were also performed. They all received autologous thrombus operation. Furthermore, western blot and RT-PCR were also used to detect the protein and mRNA expression levels of apoptosis-related factors. Our results showed that leptin could reduce the volume of cerebral infarction by about 35%. Behavioral defects can be significantly improved. In addition, midterm and long-term behavioral deficiencies had been significantly improved by leptin. Moreover, leptin significantly decreased the expression levels of caspase-3 and Bax, and increased the expression levels of Bcl-2. In conclusion, leptin has neuroprotective effects on cerebral ischemia by effectively reducing the volume of cerebral infarction.

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Section: Introductionmentioning

confidence: 99%

Neuroprotective effect of leptin on a primate model of cerebral ischemia

Cheng

Deng

Zhou

et al. 2021

Animal Biotechnology

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Stem cell-based ischemic stroke therapy: Novel modifications and clinical challenges

Sun,

Jiang,

Gao

2024

Asian Journal of Pharmaceutical Sciences

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MASTRO I: Meta-Analysis and Systematic Review of thrombectomy stent retriever outcomes: comparing functional, safety and recanalization outcomes between EmboTrap, Solitaire and Trevo in acute ischemic stroke

Zaidat

Ikeme²,

Sheth

et al. 2023

J. Comp. Eff. Res.

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Aim: Stent-retriever (SR) thrombectomy has demonstrated superior outcomes in patients with acute ischemic stroke compared with medical management alone, but differences among SRs remain unexplored. We conducted a Systematic Review/Meta-Analysis to compare outcomes between three SRs: EmboTrap ® , Solitaire™, and Trevo ® . Methods: We conducted a PRISMA-compliant Systematic Review among English-language studies published after 2014 in PubMed/MEDLINE that reported SRs in ≥25 patients. Functional and safety outcomes included 90-day modified Rankin scale (mRS 0-2), mortality, symptomatic intracranial hemorrhage (sICH), and embolization to new territory (ENT). Recanalization outcomes included modified thrombolysis in cerebral infarction (mTICI) and first-pass recanalization (FPR). We used a random effects Meta-Analysis to compare outcomes; subgroup and outlier-influencer analysis were performed to explore heterogeneity. Results: Fifty-one articles comprising 9,804 patients were included. EmboTrap had statistically significantly higher rates of mRS 0-2 (57.4%) compared with Trevo (50.0%, p = 0.013) and Solitaire (45.3%, p < 0.001). Compared with Solitaire (20.4%), EmboTrap (11.2%, p < 0.001) and Trevo (14.5%, p = 0.018) had statistically significantly lower mortality. Compared with Solitaire (7.7%), EmboTrap (3.9%, p = 0.028) and Trevo (4.6%, p = 0.049) had statistically significantly lower rates of sICH. There were no significant differences in ENT rates across all three devices (6.0% for EmboTrap, 5.3% for Trevo, and 7.7% for Solitaire, p = 0.518). EmboTrap had numerically higher rates of recanalization; however, no statistically significant differences were found. Conclusion: The results of our Systematic Review/Meta-Analysis suggest that EmboTrap may be associated with significantly improved functional outcomes compared with Solitaire and Trevo. EmboTrap and Trevo may be associated with significantly lower rates of sICH and mortality compared with Solitaire. No significant differences in recanalization and ENT rates were found. These conclusions are tempered by limitations of the analysis including variations in thrombectomy techniques in the field, highlighting the need for multi-arm RCT studies comparing different SR devices to confirm our findings.

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Comparison of different types of endovascular mechanical embolectomy in acute ischemic stroke

Cited by 3 publications

References 10 publications

Neuroprotective effect of leptin on a primate model of cerebral ischemia

Neuroprotective effect of leptin on a primate model of cerebral ischemia

Stem cell-based ischemic stroke therapy: Novel modifications and clinical challenges

MASTRO I: Meta-Analysis and Systematic Review of thrombectomy stent retriever outcomes: comparing functional, safety and recanalization outcomes between EmboTrap, Solitaire and Trevo in acute ischemic stroke

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