The role of regulatory T cells, interleukin-10 and in vivo scintigraphy in autoimmune and idiopathic diseases – Therapeutic perspectives and prognosis

Abstract

Previous studies have demonstrated the expression of the CD25 marker on the surface of naturally occurring T cells (T regs ) of mice, which have a self-reactive cellular profile. Recently, expression of other markers that aid in the identification of these cells has been detected in lymphocyte subtypes of individuals suffering of autoimmune and idiopathic diseases, including: CD25, CTLA-4 (cytotoxic T-lymphocyte antigen 4), HLA-DR (human leukocyte antigen) and Interleukin 10 (IL-10), opening new perspectives for a better understanding of an association between such receptors present on the cell surface and the prognosis of autoimmune diseases. The role of these molecules has already been described in the literature for the modulation of the inflammatory response in infectious and parasitic diseases. Thus, the function, phenotype and frequency of expression of the α-chain receptor of IL-2 (CD25) and IL-10 in lymphocyte subtypes were investigated. Murine models have been used to demonstrate a possible correlation between the expression of the CD25 marker (on the surface of CD4 lymphocytes) and the control of self-tolerance mechanisms. These studies provided support for the presentation of a review of the role of cells expressing IL-2, IL-10, HLA-DR and CTLA-4 receptors in the monitoring of immunosuppression in diseases classified as autoimmune, providing perspectives for understanding peripheral regulation mechanisms and the pathophysiology of these diseases in humans. In addition, a therapeutic approach based on the manipulation of the phenotype of these cells and ways of scintigraphically monitoring the manifestations of these diseases by labeling their receptors is discussed as a perspective. In this paper, we have included the description of experiments in ex vivo regulation of IL-10 and synthesis of thio-sugars and poly-sugars to produce radiopharmaceuticals for monitoring inflammation. These experiments may yield benefits for the treatment and prognosis of autoimmune diseases.

İlaç alerjisi olan hastalarda otoantikor sıklığı

“…Immune system abnormalities can present as immune deficiency syndromes, allergies or autoimmune diseases [8]. The relationship between immune deficiency syndromes and autoimmune diseases has been recognized for a long time [9].…”

Low Serum Interleukin-10 Is an Independent Predictive Factor for the Risk of Second Event in Clinically Isolated Syndromes

“…Regarding clinical correlations, a significantly higher CSF WBC count, number of T2 lesions, and number of Gd+ lesions in baseline MRI were found in the low serum IL-10 levels group. One possibility is that, as a key immunosuppressive cytokine, a decrease in IL-10 may contributes to an imbalance of pro-inflammatory and anti-inflammatory factors (30, 31). The relative predominance of proinflammatory factors leads to an increased inflammatory activity as evidenced by a higher CSF WBC count, greater number of lesions, and earlier disease reactivation (32).…”