Vitamin B12, bone mineral density and fracture risk in adults: A systematic review

Abstract

A real effect of vitamin B12 deficiency in bone health and the mechanisms associated with bone metabolism is not well established yet. It is extremely important to carry out more clarifying studies about this theme, especially with vulnerable groups such as postmenopausal and elderly women, as is well-known that they are greatly affected by deficiency of this vitamin.

Postoperative Osteoporosis in Subjects with Morbid Obesity Undergoing Bariatric Surgery with Gastric Bypass or Sleeve Gastrectomy

“…It is well known that postoperative deficiency of vitamin B 12 can lead to anemia [ 44 , 45 ]. Still more importantly, vitamin B 12 deficiency has been associated with osteoporosis, which was reported in a systematic review by Macedo et al [ 46 ]. Today, postoperative vitamin B 12 supplementation is routinely recommended following bariatric surgery [ 47 ].…”

B12 levels and frailty syndrome

“…Macêdo et al (2017) reviewed several studies, in which three of them demonstrated an association between vitamin B12 and fracture risk and/or bone mineral density (BMD reduction), while in fourteen studies no association was recorded[ 25 ]. In another study that Macêdo et al reviewed, it was concluded that supplementation of vitamin B12 and folic acid is beneficial for the prevention of osteoporotic fractures.…”

“…In another study that Macêdo et al reviewed, it was concluded that supplementation of vitamin B12 and folic acid is beneficial for the prevention of osteoporotic fractures. However further studies are required in order to determine the association between B12 and bone metabolism[ 25 ].…”

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“…Epidemiological evidence has considered the role of other dietary factors in relation to risk of hip fracture, such as dietary intake of carbohydrates, fats, B-vitamins, magnesium, zinc, and isoflavones [49][50][51][52][53][54][55]. These studies were not included in our review because they lacked a meta-analysis component, did not assess the effect of a dietary exposure on hip fracture risk, or met other aspects of our exclusion criteria.…”