Concomitant testicular infection by Zika virus and Schistosoma mansoni in a Brazilian young boy

Alves, Leonardo Souza; Estanislau, Cesar; Barreto, Lucio; Batista, Francisco; Toppa, Nivaldo Hartung

doi:10.1590/1806-9282.63.06.500

Cited by 5 publications

(2 citation statements)

References 17 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…39 40 Additionally, one ZIKV/Schistosma mansoni-coinfected case experienced testicular inflammation with granulomas induced by schistosome eggs. 41 Coinfections in pregnancy were described in three ZIKV coinfection types: ZIKV/MAYV, ZIKV/CHIKV/ Toxoplasma gondii and ZIKV/EBV/HHV6 coinfections. 36 37 42 In the latter two, vertical ZIKV transmission was suspected, as both fetuses were diagnosed with CZS.…”

Section: Zikv/chikv Coinfectionsmentioning

confidence: 99%

The frequency and clinical presentation of Zika virus coinfections: a systematic review

et al. 2020

View full text Add to dashboard Cite

BackgroundThere is limited knowledge on the influence of concurrent coinfections on the clinical presentation of Zika virus (ZIKV) disease.MethodsTo better understand the types, frequencies and clinical manifestations of ZIKV coinfections, we did a systematic review of four databases (PubMed, Embase, Web of Science, LILACS) without restrictions for studies on ZIKV coinfections confirmed by nucleic acid (quantitative real-time-PCR) testing of ZIKV and coinfecting pathogens. The review aimed to identify cohort, cross-sectional, case series and case report studies that described frequencies and/or clinical signs and symptoms of ZIKV coinfections. Conference abstracts, reviews, commentaries and studies with imprecise pathogen diagnoses and/or no clinical evaluations were excluded.ResultsThe search identified 34 articles from 10 countries, comprising 2 cohort, 10 cross-sectional, 8 case series and 14 case report studies. Coinfections were most frequently reported to have occurred with other arthropod-borne viruses (arboviruses); out of the 213 coinfections described, ZIKV infections co-occurred with chikungunya in 115 cases, with dengue in 68 cases and with both viruses in 19 cases. Other coinfecting agents included human immunodeficiency, Epstein-Barr, human herpes and Mayaro viruses, Leptospira spp, Toxoplasma gondii and Schistosoma mansoni. ZIKV-coinfected cases primarily presented with mild clinical features, typical of ZIKV monoinfection; however, 9% of cases in cohort and cross-sectional studies were reported to experience complications.ConclusionBased on the evidence collated in this review, coinfections do not appear to strongly influence the clinical manifestations of uncomplicated ZIKV infections. Further research is needed to confirm whether risk of severe complications is altered when ZIKV infection co-occurs with other infections.PROSPERO registration numberCRD42018111023.

show abstract

Section: Zikv/chikv Coinfectionsmentioning

confidence: 99%

The frequency and clinical presentation of Zika virus coinfections: a systematic review

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Viral DNA is frequently detected in the reproductive system of normal as well as infertile donors (48,49). Herpes virus has been detected in the semen of donors -including those with normal sperm (50,51). Some studies have also indicated active viral gene expression.…”

Section: Discussionmentioning

confidence: 99%

Listing candidate diagnostic markers and transcriptomic exploration of the molecular basis of a type of male infertility (Non-Obstructive Azoospermia), via next generation sequencing methods

Govindkumar

Basavaraju

Bajpai³

et al. 2019

Preprint

View full text Add to dashboard Cite

Studying the molecular basis of Non-Obstructive Azoospermia (NOA), a type of male infertility with failed spermatogenesis at various stages, can also help in exploring molecular basis of human spermatogenesis and possibly pave way to identify new targets for male contraceptive development. Hence, we initiated a functional genomics study by applying RNA-seq. Testicular biopsies collected from donors with Non-Obstructive Azoospermia (NOA), Obstructive Azoospermia (OA), Congenital Bilateral Absence of the Vas Deferens (CBAVD), and Varicocele (VA) conditions. Strong association of 100+ genes with human spermatogenesis and NOA has been detected via NGS-based transcriptomic analysis. In addition, 20 RNA molecules have been short-listed for potential diagnostic applications (non-obstructive azoospermia vs. obstructive azoospermia, varicocele or normal). A hierarchical list of several genes and alternatively spliced mRNAs, transcribed differentially in NOA, is reported -based on a 'strength of association'. Such association with NOA, spermatogenesis or both is a new finding for many genes as revealed by a comparison with a newly prepared comprehensive list of genes having such association with human spermatogenesis/NOA. Many top-ranking genes involved in viral gene expression were up-regulated in testes from NOA-patients, while those associated with an antiviral mechanism were down-regulated. A tangential finding: while most well-established control mRNAs did not qualify, two new ones worked best in RT-qPCR experiments. Needle-aspiration of testicular biopsies, followed by the use of short-listed promising candidate biomarkers (i.e., 16 mRNA & 4 chimeric transcripts) and control mRNAs in RT-qPCR-based diagnostic assays, may help to avoid open surgeries in future.

show abstract

Multisystem imaging review of human schistosomiasis: characteristic imaging findings

et al. 2019

View full text Add to dashboard Cite

Concomitant testicular infection by Zika virus and Schistosoma mansoni in a Brazilian young boy

Cited by 5 publications

References 17 publications

The frequency and clinical presentation of Zika virus coinfections: a systematic review

The frequency and clinical presentation of Zika virus coinfections: a systematic review

Listing candidate diagnostic markers and transcriptomic exploration of the molecular basis of a type of male infertility (Non-Obstructive Azoospermia), via next generation sequencing methods

Multisystem imaging review of human schistosomiasis: characteristic imaging findings

Contact Info

Product

Resources

About