Effect of rhubarb on extravascular lung water in patients with acute respiratory distress syndrome

Abstract

EffEct of rhubarb on Extravascular lung watEr in patiEnts with acutE rEspiratory distrEss syndromE reV assoC Med Bras 2017; 63 (5) Objective: The aim of this study was to evaluate the effect of rhubarb on extravascular lung water (EVLW) in patients with acute respiratory distress syndrome (ARDS). Method: A total of 80 patients with ARDS were randomly divided into a treatment group (40 cases) and control group (40 cases). Patients in the treatment group received rhubarb (30.0 g/d) and patients in the control group received conventional therapy for seven consecutive days. Extravascular lung water index (EVLWI) and pulmonary vascular permeability index (PVPI) were determined using pulse contour cardiac output (PiCCO) technology, and the oxygenation index was measured by blood gas analysis at baseline and on days 3, 5 and 7 after treatment. Results: The oxygenation index was higher and the levels of EVLWI and PVPI were lower after treatment in the two groups; however, these indexes showed significant differences on the 5 th and 7 th days after rhubarb treatment compared with the results in the control group (p<0.05). Conclusion: Rhubarb can decrease EVLWI and PVPI, and improve oxygenation in patients with ARDS.

An Evaluation of Traditional Persian Medicine for the Management of SARS-CoV-2

“…In comparison to the control group, the adjuvant rhubarb administration could significantly improve oxygenation. Additionally, it could decrease the extravascular lung water index and pulmonary vascular permeability index (He et al, 2017), confirming the results of the preclinical studies in a clinical setting. It should be noted that no identification process was considered for rhubarb and thus, it is not clear which species of the plant were used in this trial (He et al, 2017).…”

Impact of differences in acute respiratory distress syndrome randomised controlled trial inclusion and exclusion criteria: systematic review and meta-analysis

“…The most commonly reported P : F ratio inclusion thresholds, below which patients were included in the RCT, were ≤26.6 kPa (63/146; 43.2%) and ≤39.9 kPa (64/146; 43.8%) ( Table 1 ). The P : F ratio maximum threshold was concordant with the Berlin definition in 26/29 (89.7%) RCTs 134 , 135 , 136 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 151 , 152 , 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 compared with 101/117 (86.3%) RCTs 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 36 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 46 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , ...…”

“… 134 , 135 , 136 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 , 162 Exclusion of cardiac involvement conformed to the AECC definition (absence of clinical evidence of left atrial hypertension or pulmonary arterial wedge pressure >18 mm Hg) in 121/146 (82.9%) RCTs, 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ,…”

“… 24 , 35 , 44 , 47 , 53 , 54 , 60 , 61 , 63 , 64 , 90 , 92 , 93 , 105 , 113 , 114 , 115 , 116 , 124 , 126 , 127 , 131 , 132 , 134 , 136 , 141 , 145 , 150 , 152 , 162 Minimum time since intubation was specified in seven (4.8%; median: 1 day; range: 0.33–1) RCTs. 35 , 69 , 70 , 91 , 105 , 113 , 140 Time since admission was specified in three (2.1%; median: 2 days; range: 2–2) RCTs. 51 , 56 , 59…”

Rheum rhaponticum and Rheum rhabarbarum: a review of phytochemistry, biological activities and therapeutic potential

“…The genus Rheum L. (rhubarb) covers about 60 species of perennial herbs, belonging to the Polygonaceae family. Rhubarbs have been known worldwide (in Asia, in particular) as medicinal and/or edible plants (Agarwal et al 2001;Cao et al 2017;He et al 1992;Pourjabali et al 2017;Rehman et al 2014). Scientific interest in chemical composition and biological properties of two of the most popular rhubarb species, i.e.…”