Therapeutic use of the rebound effect of modern drugs: "New homeopathic medicines"

Abstract

The homeopathic treatment is based on the principle of therapeutic similitude, employing medicines that cause certain disorders to treat similar manifestations, stimulating a reaction of the organism against its own ailments. The occurrence of this secondary reaction of the organism, opposite in nature to the primary action of the medicines, is evidenced in the study of the rebound (paradoxical) effect of several classes of modern drugs. In this work, in addition to substantiate the principle of similitude before the experimental and clinical pharmacology, we suggest a proposal to employ hundreds of conventional drugs according to homeopathic method, applying the therapeutic similitude between the adverse events of medicines and the clinical manifestations of patients. Describing existing lines of research and a specific method for the therapeutic use of the rebound effect of modern drugs (http://www.newhomeopathicmedicines.com), we hope to minimize prejudices related to the homeopathy and contribute to a broadening of the healing art.

“Similia Similibus Curentur”: The scientific grounding of the homeopathic therapeutic principle through the systematic study of the rebound effect of modern drugs

“…Such new homeopathic medicines cover signs and symptoms absent in the classical homeopathic pathogenetic trials and will allow treating countless modern disorders, diseases, and syndromes with homeopathy. 16 , 17 , 18 , 19 , 20 , 21 , 22 …”

“…Since 2003, assuming Hahnemann's postulate that the principle of therapeutic similitude is a “natural law of cure”, the authors have been suggesting the homeopathic use of modern drugs employing the rebound effect in a therapeutic way, 16 , 17 , 18 , 19 , 20 , 21 , 22 proposing to prescribe drugs, in dynamized doses, which present a similar set of signs and symptoms in their primary action to the manifestations of sick individuals.…”

Evaluation of the Preventive Effects of Fish Oil and Sunflower Seed Oil on the Pathophysiology of Sepsis in Endotoxemic Rats

“…Our results showed that supplementation with fish oil or sunflower oil, despite their anti-inflammatory properties, not only aggravated the inflammatory conditions after endotoxemia but also increased the pro-inflammatory status by inducing platelet-leukocyte aggregation. This could be attributed to the rebound effect of fish oil or sunflower oil that might have suppressed the anti-inflammatory effects of these oils, or non-responsiveness of the rats after LPS injection due to the aggravated negative symptoms (34). The increased platelet-monocyte aggregation in group C than in group D could be explained by the stronger anti-inflammatory effect of fish oil than sunflower seed oil; therefore, leading to more pronounced rebound effect, and as a result a higher level of platelet-monocyte aggregation in the fish oil group than sunflower seed oil group.…”

“…The increased platelet-monocyte aggregation in group C than in group D could be explained by the stronger anti-inflammatory effect of fish oil than sunflower seed oil; therefore, leading to more pronounced rebound effect, and as a result a higher level of platelet-monocyte aggregation in the fish oil group than sunflower seed oil group. The rebound effects of drugs are well documented in several studies (34)(35)(36). For instance, atorvastatin withdrawal led to a rebound increase in inflammatory mediators, as a result, patients with myocardial infarction might have adverse rebound effect after cessation of statin therapy (36).…”

Antropologia Médica Vitalista: uma ampliação ao entendimento do processo de adoecimento humano

“…O princípio da similitude terapêutica emprega medicamentos que causam determinados sintomas em indivíduos sadios (experimentação patogenética homeopática) para tratar sintomas semelhantes em indivíduos doentes (similia similibus curentur), com o intuito de estimular uma reação vital curativa do organismo contra os seus próprios distúrbios 21 . Essa reação secundária (vital ou homeostática) do organismo despertada pelo tratamento homeopático está fundamentada no estudo do efeito rebote dos fármacos modernos 17,22,23 , evento adverso que pode causar transtornos graves após a descontinuação de inúmeras classes de medicamentos empregados segundo o princípio dos contrários (contraria contrariis curentur) para neutralizar os sintomas das doenças.…”